Value of Live Donor Liver Transplantation Experience in Major Hepatectomy for Hepatocellular Carcinoma

Chan, See‐Ching; Liu, Chi‐Leung; Lo, Chung‐Mau; Lam, Chi‐Ming; Poon, Ronnie Tung‐Ping; Yuen, WK; Fan, Sheung‐Tat; Wong, John

doi:10.1001/archsurg.138.3.265

Cited by 18 publications

(11 citation statements)

References 40 publications

(28 reference statements)

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“…39 Continuity of care by the same team of surgeons is logical. 40 Donor feasibility has to be made in concert with the physical condition of the recipient in terms of graft size for recipients with portal hypertension. 41 Such assessments are the key issues in counselling for the potential donor.…”

Section: Discussionmentioning

confidence: 99%

Donor quality of life before and after adult-to-adult right liver live donor liver transplantation

Chan

Liu

et al. 2006

Liver Transpl

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Donor right hepatectomy for adult-to-adult live donor liver transplantation (ALDLT) is a major surgical operation for the benefit of the recipient. Justification of procedure mandates knowledge of the possible physical and psychological negative effects on the donor. We prospectively and longitudinally quantified donor quality of life using generic and condition-specific questionnaires up to 1 year. The generic questionnaires were the Karnofsky Performance Status scale and the Chinese (Hong Kong) version of the Medical Outcomes Study 36-Item Short-Form Survey, which measures 8 health concepts: 4 physical components and 4 mental components. Within 1 year, 30 consecutive donors were included. These 11 male and 19 female donors (36.7% and 63.3%, respectively) had a median age of 35 years (range, 21-56 years). There was no donor mortality or major complications. Donor quality-of-life worsening was most significant in the first 3 postoperative months, particularly among the physical components. The physical and mental components returned to the previous levels in 6 to 12 months' time, though the Karnofsky performance scores were slightly lower at 1 year (P ϭ 0.011). Twenty-six (86.7%) donors declared that they would donate again if there were such a need and it were technically possible. It was noticed that older donors were more likely to express unwillingness to donate again. In conclusion, the temporary worsening of donor quality of life substantiates ALDLT as an acceptable treatment modality. Liver Transpl 12: 1529-1536, 2006.

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Section: Discussionmentioning

confidence: 99%

Donor quality of life before and after adult-to-adult right liver live donor liver transplantation

Chan

Liu

et al. 2006

Liver Transpl

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“…On the contrary, the transfusion of autologous blood has no influence on tumor growth. During liver transplantation, exogenous blood transfusion is known to be related with poorer prognosis 21. Intraoperative autotransfusion using an autotransfusion device can reduce the homologous transfusion, and some centers use an autotransfusion device in selected cases 22, 23.…”

Section: Discussionmentioning

confidence: 99%

Can a leukocyte depletion filter (LDF) reduce the risk of reintroduction of hepatocellular carcinoma cells?

et al. 2005

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During liver transplantation for hepatocellular carcinoma (HCC) patients, HCC could theoretically be introduced into the systemic circulation when salvaged blood is used with an autotransfusion device. Several reports have shown that some types of leukocyte depletion filters (LDFs) could completely reduce the risk for reintroducing some types of tumor cells. In this study, we tested the ability of the LDF (RCEZ1T, Pall Biomedical Co, NY, USA) to reduce the risk for reintroducing HCC cells in vitro by using a very sensitive detection method. We divided the test group into 6 groups: group I was 10 cells, group II was 20 cells, group III was 2 ؋ 10 3 cells, group IV was 2 ؋ 10 5 cells, group V was 2 ؋ 10 6 cells, and group VI was 2 ؋ 10 7 cells. The counted cells in 200 mL saline were passed through the RCEZ1T using the force of gravity. To identify the presence of cells, the pellet was resuspended, and polymerase chain reaction (PCR) was performed. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a housekeeping gene, was used as a primer. In groups I and II, the HCC cells were completely filtered in all experiments. However, in groups III, IV, and V, the HCC cells were not completely filtered in a few of the repeated experiments, with the unfiltered rate of tumor cells being between 8% and 20%. In group VI, the HCC cells were not completely filtered in all the repeated experiments.

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“…This profile is even lower when considering those patients who received heterologous transfusions only (14%). This low transfusion rate is quite favorable when compared with recent literature from other centers with expertise and high volume in hepatic resective surgery 1, 4, 5, 33, 34 . Mirroring this is a trend in minimal administration of other blood products such as FFP and platelets as well.…”

Section: Discussionmentioning

confidence: 69%

Water-jet dissection for parenchymal division during hepatectomy

Vollmer

Dixon

Sahajpal

et al. 2006

HPB

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Value of Live Donor Liver Transplantation Experience in Major Hepatectomy for Hepatocellular Carcinoma

Cited by 18 publications

References 40 publications

Donor quality of life before and after adult-to-adult right liver live donor liver transplantation

Donor quality of life before and after adult-to-adult right liver live donor liver transplantation

Can a leukocyte depletion filter (LDF) reduce the risk of reintroduction of hepatocellular carcinoma cells?

Water-jet dissection for parenchymal division during hepatectomy

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