Value of liver iron concentration in healthy volunteers assessed by MRI

Obrzut, Marzanna; Atamaniuk, Vitaliy; Glaser, Kevin J.; Ehman, Richard L.; Obrzut, Bogdan; M, Cholewa; Gutkowski, Krzysztof

doi:10.1038/s41598-020-74968-z

Cited by 20 publications

(10 citation statements)

References 43 publications

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“…We found a strong correlation between age and HIC in women, suggesting a link to the onset of menopause. Our findings regarding the effect of age on HIC are supported by the study of Obrzut et al [20], who examined considerably younger participants and reported distinctly lower HIC levels (mean: 28.7 s −1 ).…”

Section: Distribution Of Hic and Effect Of Agesupporting

confidence: 89%

Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study

et al. 2021

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Hepatic iron overload can cause severe organ damage; therefore, an early diagnosis and the identification of potential risk factors is crucial. We aimed to investigate the sex-specific distribution of hepatic iron content (HIC) in a population-based cohort and identify relevant associated factors from a panel of markers. We analyzed N = 353 participants from a cross-sectional sample (KORA FF4) who underwent whole-body magnetic resonance imaging. HIC was assessed by single-voxel spectroscopy with a high-speed T2-corrected multi-echo technique. A large panel of markers, including anthropometric, genetic, and laboratory values, as well as behavioral risk factors were assessed. Relevant factors associated with HIC were identified by variable selection based on LASSO regression with bootstrap resampling. HIC in the study sample (mean age at examination: 56.0 years, 58.4% men) was significantly lower in women (mean ± SD: 39.2 ± 4.1 s−1) than in men (41.8 ± 4.7 s−1, p < 0.001). Relevant factors associated with HIC were HbA1c as well as prediabetes for men and visceral adipose tissue as well as age for women. Hepatic fat, alcohol consumption, and genetic risk score for iron levels were associated with HIC in both sexes. In conclusion, there are sex-specific associations of HIC with markers of body composition, glucose metabolism, and alcohol consumption.

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Section: Distribution Of Hic and Effect Of Agesupporting

confidence: 89%

Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study

et al. 2021

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“…The default shim recorded high SD values, while the low fluctuation of measurements was recorded using the auto-shim technique. The overall T2* measurements recorded from the volunteers fell between 30 and 45 ms (average 36 ± 5 ms) comparable with literature 34 . The T2 magnitude measurements were presented with a slight increase for pixel sizes larger than 2.5 × 2.5 mm.…”

Section: Discussionsupporting

confidence: 87%

Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Ahmed¹,

Baldo²,

Sulieman

et al. 2021

Sci Rep

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This work aimed to investigate the effect of different shim techniques, voxel sizes, and repetition time (TR) on using theT2 and T2* sequences to determine their optimum settings to investigate the quantification of iron in transfused dependent sickle cell patients. The effect of each of these parameters was investigated on phantoms of different Gadolinium (Gd) concentrations, on 10 volunteers and 25 patients using a1 5T MRI Philips scanner. No significant difference between the three shim techniques was noticed in either T2 or T2* sequence measurements. Pixel sizes of 1 × 1 and 2 × 2 mm provided optimum results for T2 measurements. At 1 × 1 mm pixel size the T2* measurements experienced less error in measurements than the size of 2.5 × 2.5 mm used in the literature. Even though the slice thickness variation did not provide any changes in T2 measurements, the 12 mm provided optimum T2* measurements. TR variation did not yield significant changes on either T2 or T2* measurements. These results indicate that both T2 and T2* sequences can be further improved by providing more reliable measurements and reducing acquisition time.

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“…We found a strong correlation between age and HIC in women, suggesting a link to the onset of menopause. Our findings regarding the effect of age on HIC are supported by the study of Obrzut et al (25), who examined considerably younger participants and reported distinctly lower HIC levels (mean: 28.7 s -1 ).…”

Section: Distribution Of Hic and Effect Of Agesupporting

confidence: 89%

Distribution and associated factors of hepatic iron – a population-based imaging study

Maier

Krüchten

Lorbeer

et al. 2021

Preprint

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Context: Hepatic iron overload can cause severe organ damage. Therefore, an early diagnosis is crucial, and identification of modifiable risk factors could help to prevent manifestations of iron-driven complications. Objective: To investigate the sex–specific distribution of hepatic iron content (HIC) in a population-based sample, and to identify relevant associated factors from a panel of markers. Methods: We analysed N=353 participants from a cross–sectional, population–based cohort in Southern Germany (KORA FF4) who underwent whole–body magnetic resonance imaging. HIC was assessed by single–voxel spectroscopy with a high–speed T2–corrected multi–echo technique. A large panel of markers, including anthropometric, genetic and laboratory values as well as behavioural risk factors were assessed. Relevant factors associated with HIC were identified by variable selection based on LASSO regression with bootstrap resampling. Results: HIC in the study sample (mean age at examination was 56.0 years, 58.4% were men) was significantly lower in women (mean±SD: 39.2±4.1 s−1) than in men (41.8±4.7 s−1, p<0.001). Relevant factors associated with HIC were HbA1c and prediabetes for men, and visceral adipose tissue and age for women. Hepatic fat, alcohol consumption, and a genetic risk score for iron levels were associated with HIC in both sexes. Conclusion: There are sex–specific associations of HIC with markers of body composition, glucose metabolism and alcohol consumption.

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Value of liver iron concentration in healthy volunteers assessed by MRI

Cited by 20 publications

References 43 publications

Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study

Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study

Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Distribution and associated factors of hepatic iron – a population-based imaging study

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