Value of Magnetic Resonance Imaging for Nodal Staging in Patients with Head and Neck Squamous Cell Carcinoma: A Meta-analysis

Wu, Lian Ming; Xu, Jian; Liu, Man Ju; Zhang, Xiao Fei; Hua, Jia; Zheng, Jasmine; Hu, Jia

doi:10.1016/j.acra.2011.10.027

Cited by 40 publications

(20 citation statements)

References 40 publications

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“…The software-based fusion of PET and MRI sets and the required rebedding of all patients between two scans might impact the precision of the coregistration images and might bias lymph node metastasis detection and N-staging [12]. These disadvantages of software-based fusion images could be overcome by integrated PET/MRI [23]. The patient selection criteria of these studies are different.…”

Section: Discussionmentioning

confidence: 96%

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

Xiao

Chen²,

Shi³

et al. 2015

Nuclear Medicine Communications

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Section: Discussionmentioning

confidence: 96%

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

Xiao

Chen²,

Shi³

et al. 2015

Nuclear Medicine Communications

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“…To date, several reports have indicated that DWI is a useful method in the differentiation of metastatic from non-metastatic cervical lymph nodes in patients with head and neck tumours, on the basis that it provides a more detailed characterization of tissue at both a microscopic level and in terms of an actual pathological process. [7][8][9] However, studies exploiting DWI to distinguish metastatic from benign RLNs in patients with NPC are limited. Here, DWI was evaluated as a possible clinical strategy to differentiate metastatic from non-metastatic RLNs in patients with NPC and compared with the current standard of size-based criteria.…”

Section: Introductionmentioning

confidence: 99%

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Xw²,

Zj³

et al. 2015

Dentomaxillofacial Radiology

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Objectives: To evaluate the diagnostic value of diffusion-weighted MRI for differentiating metastatic from non-metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal carcinoma (NPC). Methods: Untreated patients with NPC (n 5 145) were scanned with both morphological MRI and diffusion-weighted imaging (DWI). RLNs (n 5 335) were classified as metastatic on the basis of response to therapy as assessed on follow-up MRI. Morphological (short-and long-axial diameters) and functional [mean apparent diffusion coefficient (ADC) and minimum ADC values] parameters of the RLNs were derived from DWI and compared between metastatic and non-metastatic groups. A receiver operating characteristic curve and the area under the curve were used to evaluate the effectiveness of individual criteria and to generate threshold values to diagnose RLN metastases. Results: Statistically significant differences between metastatic and non-metastatic RLNs were found for all four parameters derived from DWI (p , 0.001). At threshold values, accuracies of the ADC-based criteria (0.938 and 0.965 for mean and minimum ADC values, respectively) were greater than that of size-based criteria (0.838 and 0.809 for short-and longaxial diameters). The minimum ADC value at the threshold of 0.89 3 10 23 mm 2 s 21 was the most effective of all parameters in differentiating metastatic from non-metastatic RLNs with the sensitivity of 95.7%, specificity of 95.1% and accuracy of 96.5%. Conclusions: DWI is feasible for differentiating metastatic RLNs from non-metastatic nodes in patients with NPC with high accuracy, and the minimum ADC derived from DWI could serve as a standard clinical marker for disease status. Dentomaxillofacial Radiology (2015Radiology ( ) 44, 20140126. doi: 10.1259 Cite this article as: Li H, Liu X-W, Geng Z-J, Wang D-L, Xie C-M. Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma. Dentomaxillofac Radiol 2015; 44: 20140126.

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“…A recent meta‐analysis on the value of MRI for nodal staging in patients with HNSCC showed that the subgroup of MRI with diffusion‐weighted imaging had a significantly higher pooled sensitivity (86%; 95% CI = 78–92) than conventional MRI (71%; 95% CI = 68–79). The specificity was similar: 95%; CI = 93–97 and 95%; 95% CI = 92–97, respectively …”

Section: Introductionmentioning

confidence: 81%

Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma

et al. 2014

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Regional metastasis is a prominent feature of head and neck squamous cell carcinoma (HNSCC) and is an important prognostic factor. The currently available imaging techniques for assessment of the neck have limitations in accuracy; thus, elective neck dissection has remained the usual choice of management of the clinically N0 neck (cN0) for tumors with significant (≥20%) incidence of occult regional metastasis. As a consequence, the majority of patients without regional metastasis will undergo unnecessary treatment. The purpose of this review was to discuss new developments in techniques that potentially improve the accuracy of the assessment of the neck in patients with HNSCC. Although imaging has improved in the last decades, a limitation common to all imaging techniques is a lack of sensitivity for small tumor deposits. Therefore, complementary to improvements in imaging techniques, developments in more invasive diagnostic procedures, such as sentinel node biopsy (SNB) will add to the accuracy of diagnostic algorithms for the staging of the neck.

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Value of Magnetic Resonance Imaging for Nodal Staging in Patients with Head and Neck Squamous Cell Carcinoma: A Meta-analysis

Cited by 40 publications

References 40 publications

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma

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