Value of maternal procalcitonin levels for predicting subclinical intra‐amniotic infection in preterm premature rupture of membranes

Oludag, Tülay; Göde, Funda; Çağlayan, Erkan; Saatli, Bahadır; Okyay, Recep Emre; Altunyurt, Sabahattin

doi:10.1111/jog.12273

Cited by 44 publications

(49 citation statements)

References 26 publications

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“…In addition, recent studies have shown that procalcitonin is more sensitive and specific than CRP in the early detection of bacterial infection among infants and neonates. However, there are limited studies on the prediction of early onset neonatal sepsis (EONS) with maternal blood procalcitonin level [12] . It was hypothesized that maternal blood procalcitonin concentrations are upregulated in pregnancies complicated with PPROM before the occurrence of clinical CA and neonatal infection.…”

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confidence: 99%

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Çetin¹,

Aydın²,

Verit³

et al. 2016

Gynecol Obstet Invest

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Background: This study is aimed at comparing the early diagnostic accuracy of maternal blood white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin in predicting early onset neonatal sepsis (EONS) among early preterm premature rupture of membrane (PPROM) pregnancies. Methods: A total of 57 consecutive pregnancies, complicated with PPROM, between 24 and 34 gestational weeks were recruited to the study at Suleymaniye Maternity Education and Research Hospital, Istanbul, Turkey between January 2012 and January 2013. All patients were hospitalized and followed up with expectant management. Maternal blood WBC count, CRP and procalcitonin levels were measured in the first 12 h of membrane rupture. EONS was diagnosed using clinical and laboratory findings, and obstetric and neonatal outcomes were noted. Results: The cutoff value for maternal blood CRP was ≥9.49 mg/dl. This value predicted EONS with 77.8% sensitivity, 80.0% specificity, 77.8% positive predictive value (PPV) and 80.0% negative predictive value (NPV). The cutoff value for maternal blood procalcitonin was 0.071 ng/ml. This value predicted EONS with 85.2% sensitivity, 86.7% specificity, 85.2% PPV and 86.7% NPV. Conclusion: Maternal blood procalcitonin levels were superior to maternal blood CRP and WBC count in predicting EONS. Consequently, the maternal blood procalcitonin level is a clinically useful, non-invasive and reliable biomarker in antenatal prediction of EONS.

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confidence: 99%

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Çetin¹,

Aydın²,

Verit³

et al. 2016

Gynecol Obstet Invest

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“…Oludaq et al showed that the maternal serum level of PCT in women with PPROM who also had histologic chorioamnionitis was significantly higher than the maternal serum level of PCT in women with PPROM who did not have chorioamnionitis. Moreover, the sensitivity and specificity of PCT were 92.3% and 68.4%, respectively, at 0.054 ng/ml serum level for the diagnosis of chorioamnionitis (17).…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of PCT higher than 0.06 ng/ml were considered an increased amount. This amount was selected because of the use of different cutoff points in the reviewed articles, the population proximity of the neighboring country, Turkey, to Iran, and the novelty of our study (8,17). A cobas e411 analyzer and a Roche diagnostic kit (Lot 187-424-02) were used to measure the level of PCT.…”

Section: Laminating With Entellan Merckmentioning

confidence: 99%

Predictive Value of Maternal Serum Level of Procalcitonin in Diagnosing Chorioamnionitis in Mothers with Preterm Premature Rupture of Membrane (PROM)

Seivani

Broumand

Naji

2017

IMMINV

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Background: Premature rupture of membrane (PROM) is the rupture of fetal membranes at least 1 hour before the onset of labor pain. In this study, we sought to determine the predictive value of maternal serum level of procalcitonin (PCT) in the early diagnosis of chorioamnionitis in women with preterm PROM (PPROM). Methods: In this prospective cohort study, owing to limited financial resources, 48 patients with PPROM in the Kosar Ward of Motahari Hospital in Urmia, Iran were selected to comprise the sample. Inclusion criteria were amniotic fluid leak, positive ferning and nitrazine tests, gestational age 28-33 weeks, and lack of fetal tachycardia. Exclusion criteria were chronic and congenital heart disease and use of non-steroidal antiinflammatory drugs. Data were analyzed using SPSS v. 19 software; descriptive statistics, independent t-tests, and the Pearson test were also performed. Results: We studied 48 pregnant women and their neonates. Approximately 40% of women had chorioamnionitis; approximately 60% of women did not have chorioamnionitis. Moreover, approximately 69% of the neonates had a 5-minute Apgar score ≥7. A significant correlation was observed between women who had histopathology confirmed chorioamnionitis and neonate hospitalization in the neonatal intensive care unit (P<0.001). The sensitivity, specificity, and positive and negative predictive values of PCT inflammatory indices were 100%, 79%, 57.5%, and 100%, respectively, for the histopathologic diagnosis of chorioamnionitis. Conclusion: In pregnant women, we found a significant correlation between PCT index at delivery and histopathologic chorioamnionitis.

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“…Once the infection is under control and the patient's condition has improved, the PCT concentration drops. Recently, the PCT concentration has been widely used as a standard for bacterial infection detection and as a guideline for antibiotic use (8)(9)(10). Studies have shown that both CRP and PCT have high sensitivities and specificities in PROM associated with intrauterine infection.…”

Section: Introductionmentioning

confidence: 99%

“…They can be used to predict asymptomatic intrauterine infection. However, the results have great discrepancy in different studies (5)(6)(7)(8)(9)(10). To further investigates the clinical application value of PCT and CRP in the early prediction and diagnosis of subclinical intrauterine infection in patients with premature rupture of membranes (PROM), A retrospective analysis was performed based on 276 patients with PROM during pregnancy that were admitted into our hospital between January 2011 and January 2016.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of procalcitonin or c-reactive protein for subclinical intrauterine infection in patients with premature rupture of membranes (PROM)

Wang

et al. 2016

JPM

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Introduction: to evaluate the diagnostic value of procalcitonin (PCT) and C-reactive protein (CRP) for the prediction of subclinical intrauterine infection in patients with premature rupture of membranes (PROM). Methods: a retrospective analysis was performed based on patients with PROM admitted into our hospital between January 2011 and January 2016. Using the pathological diagnosis of placenta as the gold standard, the sensitivities, specificities, positive predictive values, and negative predictive values of PCT and CRP for the diagnosis of subclinical intrauterine infection at different gestational weeks were analyzed. Further, the diagnostic accuracies were compared according to their receiver operating characteristic (ROC) curves.

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Value of maternal procalcitonin levels for predicting subclinical intra‐amniotic infection in preterm premature rupture of membranes

Abstract: ProCT levels were significantly higher in patients with PPROM, and facilitate identification of those who require expectant management.

Cited by 44 publications

References 26 publications

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Predictive Value of Maternal Serum Level of Procalcitonin in Diagnosing Chorioamnionitis in Mothers with Preterm Premature Rupture of Membrane (PROM)

Predictive value of procalcitonin or c-reactive protein for subclinical intrauterine infection in patients with premature rupture of membranes (PROM)

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