Value of negatively correlated miR-205-5p/HMGB3 and miR-96-5p/FOXO1 on the diagnosis of breast cancer and benign breast diseases

Peng, Shuang; Zou, Xuan; Geng, Xiangnan; Wang, Tongshan; Zhu, Wei; Xia, Tiansong

doi:10.1016/j.cpt.2023.04.002

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…These findings are confirmed by miRNA feedback inhibition of FOXO3a in the Heceptin-resistant HER2positive breast cancer cell sublines SKBR3-pool2 (pool2) and BT474-HR20 (HR20) derived from SKBR3 and BT474 [140]. In addition to FOXO3a, FOXO1 was also downregulated by miR-96-5p in breast cancer, suggesting that regulation of FOXO proteins by miRNA plays an important role in tumor invasiveness [141,142]. However, studies suggest that the mutually antagonizing players FOXOs and c-Myc can work together under the control of epigenetic factors, to form an MLL2/FOXO/c-Myc axis that is activated by lapatinib, a drug used to treat HER2+ breast cancer, thereby reducing sensitivity to the drug [143].…”

Section: Foxomentioning

confidence: 60%

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

Milković,

Mlinarić,

Lučić

et al. 2023

Cancers

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Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions.

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Section: Foxomentioning

confidence: 60%

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

Milković,

Mlinarić,

Lučić

et al. 2023

Cancers

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“…Forfeiture of self-renewing capacity associated with epithelial stem cells, suppresses proliferation and colony formation [61] miRNA-205 HMGB3, Notch-2 Suppresses proliferation and invasion and inhibits EMT and stem cell properties [62,63] miRNA-206 Cyclin D2, Cx43 Reduces migration, invasion, and metastasis [64,65] miRNA-223 HAX-1 Re-sensitizes TNBC stem cells to tumor necrosis factor-related apoptosis [66] miRNA-483-3p Cyclin E1, p-NPAT, NPAT, CDK2 Anti-proliferative and G1-S cell cycle arrest [67] miRNA-497 Cyclin E1 Anti-proliferative and reduces migration [68] miRNA-519d-3p LIMK1 Suppresses growth and motility [69] Studying OncomiRs and tumor-suppressive miRNAs in breast cancer is of paramount importance due to several reasons. Interactions between OncomiRs and tumor-suppressive miRNAs provide insight into the molecular mechanisms underlying breast cancer progression.…”

mentioning

confidence: 99%

Functions of Differentially Regulated miRNAs in Breast Cancer Progression: Potential Markers for Early Detection and Candidates for Therapy

Subramanian,

Sinha

2024

Biomedicines

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Breast cancer remains a major global health concern, emphasizing the need for reliable biomarkers to enhance early detection and therapeutic interventions. MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNA (~22 nt in length) molecules, which are aberrantly expressed in cancer and seem to influence tumor behavior and progression. Specific miRNA dysregulation has been associated with breast cancer initiation, proliferation, invasion, and metastasis. Understanding the functional roles of these miRNAs provides valuable insights into the intricate molecular mechanisms underlying breast cancer progression. The diagnostic potential of miRNAs as non-invasive biomarkers for early breast cancer detection is a burgeoning area of research. This review aims to elucidate the functions of differentially regulated miRNAs in breast cancer progression and assess their potential as markers for early detection, stage-specific biomarkers, and therapeutic targets. Furthermore, the ability of specific miRNAs to serve as prognostic indicators and predictors of treatment response highlights their potential clinical utility in guiding personalized therapeutic interventions.

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Connecting scientists and oncologists for advances

Yang,

Wu,

Zhu

2024

Cancer Pathogenesis and Therapy

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Value of negatively correlated miR-205-5p/HMGB3 and miR-96-5p/FOXO1 on the diagnosis of breast cancer and benign breast diseases

Cited by 3 publications

References 30 publications

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

Functions of Differentially Regulated miRNAs in Breast Cancer Progression: Potential Markers for Early Detection and Candidates for Therapy

Connecting scientists and oncologists for advances

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