Value of ovarian stromal blood flow velocity measurement after pituitary suppression in the prediction of ovarian responsiveness and outcome of in vitro fertilization treatment

Engmann, Lawrence; Sladkevicius, Povilas; Agrawal, Rina; Bekir, Jinan; Campbell, Stuart; Tan, Seang Lin

doi:10.1016/s0015-0282(98)00406-3

Cited by 146 publications

(56 citation statements)

References 34 publications

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“…A number of studies have showed a relationship between ovarian stromal blood flow early in the cycle and the ovarian responsiveness (11,(26)(27)(28)(29). A lower IOA PI early in the cycle (day 2 or 3) is associated with a larger number of growing follicles (11) and a larger number of oocytes retrieved (29).…”

Section: Discussionmentioning

confidence: 99%

Power Doppler ultrasound assessment of follicular vascularity in the early follicular phase and its relationship with outcome of in vitro fertilization

Shrestha

Costello

Sjöblom

et al. 2006

J Assist Reprod Genet

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Objective : To determine whether ovarian perifollicular blood flow (PFBF) in the early follicular phase (EFP) was associated with treatment outcome. Design : Retrospective longitudinal cohort study. Setting : Tertiary referral centre/university hospital. Patients : Thirty-four women underwent 37 IVF cycles, which resulted in 35 embryo transfers. Interventions : Serial transvaginal scans using power Doppler ultrasound during the follicular phase. Ovarian PFBF of follicles ≥ 5 mm was subjectively assessed using a modified grading system (grades 0-4). Main outcome measures : Ovarian PFBF and pregnancy. Results : Treatment cycles were retrospectively divided into two groups: Group 1 (n = 20) had cycles with at least one small (5-10 mm) or medium (11-14 mm) size follicle(s) of high grade (2-4) PFBF on cycle day 5 or 6 or 7; and Group 2 (n = 17), had cycles that did not. Group 1 had a significantly higher proportion of high grade large follicles in the late follicular phase (35% vs. 21%) (OR 2.0; 95% CI 1.1-3.7) and higher clinical pregnancy rate (47% vs. 12%) (OR 6.3; CI 1.1-35.7) compared to Group 2. Conclusion : High grade ovarian PFBF in the EFP during IVF is associated with both high grade PFBF in the late follicular phase and a higher clinical pregnancy rate.

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Section: Discussionmentioning

confidence: 99%

Power Doppler ultrasound assessment of follicular vascularity in the early follicular phase and its relationship with outcome of in vitro fertilization

Shrestha

Costello

Sjöblom

et al. 2006

J Assist Reprod Genet

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“…[9][10][11][12][13] It has been reported that ovarian stromal peak systolic velocity after pituitary suppression is a good predictor of ovarian response, more important than age and basal FSH and estradiol levels. 13 Recent studies using 3D-PDA support the findings that ovarian vascularity indices on the human chorionic gonadotropin administration day after controlled ovarian stimulation with gonadotropins are significantly higher in hyper-responding women 24 and lower in poor responders. 25 However, Jarvela and coworkers 26 observed that ovarian 3D power Doppler indices after pituitary suppression were not correlated with the number of recovered oocytes, and they did not provide more information than classic ultrasonographic parameters.…”

Section: Discussionmentioning

confidence: 99%

Intraobserver and Interobserver Reproducibility of Ovarian Volume, Antral Follicle Count, and Vascularity Indices Obtained With Transvaginal 3-Dimensional Ultrasonography, Power Doppler Angiography, and the Virtual Organ Computer-Aided Analysis Imaging Pr

Mercé

Gómez

Engels

et al. 2005

Journal of Ultrasound in Medicine

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Objectives. The purpose of this study was to assess intraobserver and interobserver reproducibility of the parameters of ovarian response and oocyte ability, studied by 3-dimensional ultrasonography and power Doppler angiography (PDA), and the possible influence of the ovarian functional stage. Methods. Twenty-nine women were included in an in vitro fertilization program. Fourteen women were evaluated after pituitary suppression (basal group), and 15 were scanned on the human chorionic gonadotropin administration day, after gonadotropin ovarian stimulation (stimulated group). A first observer acquired 2 volumes for each ovary. Another observer performed a second analysis of the volumes acquired by the first observer. We analyzed ovarian volume, follicle number in the basal group, vascularization index, flow index, and vascularization-flow index. The volumes were processed by the Virtual Organ Computer-Aided Analysis imaging program using plane A and 15°rotational steps. Results. Ovarian volume showed excellent intraobserver and interobserver agreement, with an intraclass correlation coefficient (Intra-CC) and an interclass correlation coefficient (Inter-CC) close to the unit. The Intra-CC and Inter-CC about the number of follicles were 0.964 and 0.978, respectively. Vascularity indices showed an Intra-CC greater than 0.90. The vascularization index and the vascularization-flow index showed higher interobserver than intraobserver reproducibility (Inter-CC > 0.96 for both). The flow index Inter-CC was 0.898. The reproducibility differences between the basal and stimulated ovary measurements were not significant. Conclusions. There is an excellent intraobserver and interobserver reproducibility of the ovarian volume, follicle counts, and 3-dimensional PDA indices. The ovarian functional stage has no influence on the reliability. Three-dimensional ultrasonography and PDA improve the study of ovarian parameters, and their reliability impels a change in the current clinical routine of performing and interpreting ultrasonography.

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“…Engmann et al suggested an association between ovarian stromal blood flow PSV after pituitary suppression and the number of oocytes retrieved. 8 NgEHY et al opined differently and demonstrated in their study that ovarian stromal blood flow indices measured by 2D Power Doppler ultrasound had no predictive value for the ovarian response. 9 In the present study, the ovarian responsiveness, in terms of the number of oocytes retrieved, was found to be correlated with the ovarian stromal blood flow.…”

Section: Discussionmentioning

confidence: 96%

Clinical significance of ovarian stromal blood flow in assessment of ovarian response in stimulated cycle for in vitro fertilization

Arora

Gainder

Dhaliwal

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Value of ovarian stromal blood flow velocity measurement after pituitary suppression in the prediction of ovarian responsiveness and outcome of in vitro fertilization treatment

Cited by 146 publications

References 34 publications

Power Doppler ultrasound assessment of follicular vascularity in the early follicular phase and its relationship with outcome of in vitro fertilization

Power Doppler ultrasound assessment of follicular vascularity in the early follicular phase and its relationship with outcome of in vitro fertilization

Intraobserver and Interobserver Reproducibility of Ovarian Volume, Antral Follicle Count, and Vascularity Indices Obtained With Transvaginal 3-Dimensional Ultrasonography, Power Doppler Angiography, and the Virtual Organ Computer-Aided Analysis Imaging Pr

Clinical significance of ovarian stromal blood flow in assessment of ovarian response in stimulated cycle for in vitro fertilization

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