Value of planar lymphoscintigraphy (PL) versus SPECT/CT in evaluation of sentinel lymph node in trunk melanoma — one center, large series retrospective study

Benke, Małgorzata; Wocial, Krzysztof; Lewandowska, Weronika; Rutkowski, Piotr; Teterycz, Paweł; Jarek, Piotr; Dedecjus, Marek

doi:10.5603/nmr.a2018.0022

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…One additional record was retrieved after cross checking the references. The characteristics of the 20 studies [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] selected for the meta-analysis were presented in Table 1 . Only 17/19 studies with a total number of 1438 patients were available for the calculation of the pooled DR of the SPECT/CT and PL.…”

Section: Resultsmentioning

confidence: 99%

Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis

Quartuccio

Garau

Arnone

et al. 2020

JCM

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We compared the detection rate (DR) for sentinel lymph nodes (SLNS), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the impact of SPECT/CT on surgical plans. Articles containing head-to-head comparisons between SPECT/CT and PL were searched in Pubmed/MEDLINE and Scopus. The literature search was updated until December 31st, 2019. DR was calculated on a per-patient-based analysis; the studies were pooled by their odds ratios (ORs) with a random effects model to assess the significance of difference (p < 0.05). The number of additional SLNs (calculated as the relative risk) and pooled proportion of patients with additional SLNs were investigated. The pooled ratio of surgical procedures influenced by the SPECT/CT findings was calculated. Seventeen studies with 1438 patients were eligible for the calculation of DR of SPECT/CT and PL. The average DR was 98.28% (95% confidence interval (95% CI): 97.94–99.19%) for the SPECT/CT and 95.53% (95% CI: 92.55–97.77%) for the PL; OR of 2.31 (95% CI: 1.66–4.18, p < 0.001) in favor of the SPECT/CT. There was a relative risk of a higher number of SLNs (1.13) for the SPECT/CT and 17.87% of patients with additional SLNs were detected by SPECT/CT. The average impact of SPECT/CT on surgery resulted in 37.43% of cases. This meta-analysis favored SPECT/CT over PL for the identification of SLNs in patients with melanoma due to a higher DR, reproducibility, number of SLNs depicted, proportion of patients with additional SLNs and the impact on the surgical plan. However, PL remains a good option due to the high values of the DR for SLNs.

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Section: Resultsmentioning

confidence: 99%

Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis

Quartuccio

Garau

Arnone

et al. 2020

JCM

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“…Основные преимущества метода по сравнению с указанным выше исследованы и определены на пациентах с меланомой кожи различной локализации. Способность лучше отображать пути лимфодренажа (в особенности нетипичные локализации СЛУ) и бóльшая чувствительность в обнаружении были неоднократно продемонстрированы [10][11][12][13][14][15].…”

Section: рефератunclassified

“…Преимущества ОФЭКТ/КТ при меланоме кожи также заключаются в возможностях минимизации ошибок детекции при расположении СЛУ вблизи места инъекции, ввиду чего снижается количество ЛО результатов. Эти преимущества могут привести к изменению хирургического подхода [13,14,21,22,31], что было продемонстрировано в проспективном мультицентровом исследовании МАГАТЭ 2015 г. [15]: у 97 пациентов с меланомой кожи в результате дополнительно проведенной ОФЭКТ/КТ ведение было скорректировано у 41,6, 39,7, 33,3 и 30,2 % пациентов с поражениями головы и шеи, туловища, нижних и верхних конечностей соответственно.…”

Section: рефератunclassified

The Efficacy of Radionuclide Imaging Techniques at Sentinel Node Identification in Patients with Cutaneous Melanoma

Abdulova¹,

Крылов

Рыжков³

et al. 2021

jour

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ЯдернаЯ медицинаЭффективность методов радионуклидной визуализации сторожевого лимфоузла у пациентов с меланомой кожи л.Ю. абдулова 1 , а.с. крылов 1 , а.д. рыжков 1,2 , е.а. николаева 1 , т.в. захарова 1 , м.е. Билик 1 , к.а. Барышников 1

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“…Benke et al . [ 73 ] demonstrated in patients with trunk melanoma that SPECT/CT located significantly more SLNs than planar lymphoscintigraphy; furthermore, the average number of lymph nodes detected in a patient-based analysis was significantly higher when SPECT/CT was performed. Analysis of planar imaging revealed a 95.1% sensitivity (SS - P < 0.05, CI 90-95.1%), positive predictive value (PPV) of 95.6% (p < 0.05, CI 93.4-97.3%) and an accuracy (ACC) of 89.4% (p < 0.05, CI 86.5-91.9%).…”

Section: Spect/ct Vs Planar Imagingmentioning

confidence: 99%

Sentinel Node Identification in Melanoma: Current Clinical Impact, New Emerging SPECT Radiotracers and Technological Advancements. An Update of the Last Decade

Quartuccio

Siracusa

Pappalardo

et al. 2020

CRP

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Background: Melanoma is the most lethal skin cancer with a mortality rate of 262 cases per 100.000 cases. The sentinel lymph node (SLN) is the first lymph node draining the tumor. SLN biopsy is a widely accepted procedure in the clinical setting since it provides important prognostic information, which helps patient management, and avoids the side effects of complete lymph node dissection. The rationale of identifying and removing the SLN relies on the low probability of subsequent metastatic nodes in case of a negative histological exam performed in the SLN. Discussion: Recently, new analytical approaches, based on the evaluation of scintigraphic images are also exploring the possibility to predict the metastatic involvement of the SLN. 99mTc-labeled colloids are still the most commonly used radiotracers but new promising radiotracers, such as 99mTc- Tilmanocept, are now on the market. In the last decades, single photon emission computed tomography- computerized tomography (SPECT/CT) has gained wider diffusion in clinical departments and there is large evidence about its superior diagnostic accuracy over planar lymphoscintigraphy (PL) in the detection of SLN in patients with melanoma. Scientists are also investigating new hybrid techniques combining functional and anatomical images for the depiction of SLN but further evidence about their value is needed. Conclusion: This review examined the predictive and prognostic factors of lymphoscintigraphy for metastatic involvement of SLN, the currently available and emerging radiotracers and the evidence of the additional value of SPECT/CT over PL for the identification of SLN in patients with melanoma. Finally, the review discussed the most recent technical advances in the field.

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Value of planar lymphoscintigraphy (PL) versus SPECT/CT in evaluation of sentinel lymph node in trunk melanoma — one center, large series retrospective study

Abstract: BACKGROUND: Localization and histopathological examination of sentinel lymph node is a standard of melanoma treatment. The first stage of identification of the SLN is the preoperative lymphoscintigraphy. The aim of this study was to assess and

Cited by 13 publications

References 31 publications

Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis

Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis

The Efficacy of Radionuclide Imaging Techniques at Sentinel Node Identification in Patients with Cutaneous Melanoma

Sentinel Node Identification in Melanoma: Current Clinical Impact, New Emerging SPECT Radiotracers and Technological Advancements. An Update of the Last Decade

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