2020
DOI: 10.1007/s10620-020-06710-8
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Value of Plasma Methylated SFRP2 in Prognosis of Gastric Cancer

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Cited by 18 publications
(9 citation statements)
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“…[ 22 ] Also, methylated SFRP2 in plasma was critical for the prognosis and early detection of gastric cancer. [ 23 , 24 ] Li et al [ 25 ] found that SFRP2 modulated the apoptosis and metastasis of non‑small cell lung cancer A549 cells by regulating mitochondrial fission via Wnt pathways. Recent study revealed that high expression of SFRP2was associated with primary tumor size, TNM stage, and lymph node metastases of breast cancer and lead to poor prognosis.…”
Section: Discussionmentioning
confidence: 99%
“…[ 22 ] Also, methylated SFRP2 in plasma was critical for the prognosis and early detection of gastric cancer. [ 23 , 24 ] Li et al [ 25 ] found that SFRP2 modulated the apoptosis and metastasis of non‑small cell lung cancer A549 cells by regulating mitochondrial fission via Wnt pathways. Recent study revealed that high expression of SFRP2was associated with primary tumor size, TNM stage, and lymph node metastases of breast cancer and lead to poor prognosis.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies showed that in the gastric carcinoma microbiota, increased nitrate reductase and nitrite reductase functions were considered as drivers of cancer development [ 37 , 39 , 61 ]. In order to assess this risk, we next addressed the functional features of the microbiota.…”
Section: Discussionmentioning
confidence: 99%
“…Niche-specific microbial networks reflect the disease-specific microbiome, and disease-associated bacteria can form a cooperative network, contributing to the disease [ 36 , 37 ]. In addition, previous research has mainly focused on the gastric microbiome of patients with gastric cancer rather than precancerous lesions such as gastritis atrophy (AG) [ 14 , 29 , 32 , 34 , 38 , 39 ].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, it could be used as a prognostic biomarker of GC (Figure 1). Hypermethylation of most genes such as APC, E-cadherin, UCHL1, SPG20, RASSF1A, SFRP2, CDH1, THBS1, SOX17, Wif-1, RNF-180, MED12L, HMLH1, MGMT, FLNC, LOX, HOXD10, BNIP3, and PCDH10 was significantly associated with adverse prognosis in GC (Balgkouranidou et al, 2015;Cheung et al, 2012;Ikoma et al, 2006;Karamitrousis et al, 2021;Necula et al, 2019;Pimson et al, 2016;Wang et al, 2015;Yan et al, 2021;Yu et al, 2012;Zhang et al, 2014) (Table 2). Additionally, Xie et al found that PBX3 methylation in peripheral blood leukocytes was associated with poorer GC prognosis only in the elderly group (HR = 1.678, 95% CI = 1.046-2.693) and the female group (HR = 2.058, 95% CI = 1.024-4.137) (Xie et al, 2020).…”
Section: Prognostic Biomarkersmentioning
confidence: 99%