Value of Porous Titanium Alloy Plates for Chest Wall Reconstruction after Resection of Chest Wall Tumors

Qi, Yu; Li, Xin; Zhao, Song; Han, Yong

doi:10.7314/apjcp.2014.15.11.4535

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Metastasis in patients with malignant neoplasms is the leading cause of cancer-associated mortality (18)(19)(20). Despite recent advancements, there are limited effective therapies available for patients with metastatic lung cancer due to drug resistance or serious side effects (21,22) Therefore, novel alternative therapies to prevent tumor migration and invasion are required for patients with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line

et al. 2016

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Abstract. The bark of Pinus massoniana is a traditionalChinese medicine for the treatment of various health disorders. Previous studies have demonstrated that P. massoniana bark extract (PMBE) may induce the apoptosis of hepatoma and cervical cancer cells. However, whether PMBE is able to inhibit the migration of lung cancer cells requires further investigation. In the current study, the effects of PMBE on the viability of human lung cancer A549 cells were detected using an MTT assay. The migration of lung cancer cells following exposure to PMBE were quantified using wound healing and Transwell assays, respectively. The expression levels of matrix metalloproteinase (MMP)-9 were determined using western blotting. The results revealed that PMBE significantly inhibited the growth of the lung cancer cells. In addition, the wound closure rate and the migration of the lung cancer cells were suppressed by PMBE. Furthermore, the expression levels of MMP-9 were reduced. These findings indicated that PMBE is able to restrict the migration and invasion of lung cancer cells, and that PMBE may serve as a novel therapeutic agent for patients with metastatic lung cancer in the future.

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Section: Discussionmentioning

confidence: 99%

Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line

et al. 2016

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“…Therefore, it is routine to implant a prosthesis for post-CWR chest wall reconstruction. Due to excellent biocompatibility and mechanical properties, lightweight, and low radiological interference, titanium-based materials are widely applied for chest wall repair and reconstruction [2,3]. Whereas, currently applied titanium-based prostheses have mainly demonstrated their mechanical properties and support performances, without considering their anti-tumor and osteogenesis-enabling properties, especially the efficacy in inhibiting tumor recurrence.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas, currently applied titanium-based prostheses have mainly demonstrated their mechanical properties and support performances, without considering their anti-tumor and osteogenesis-enabling properties, especially the efficacy in inhibiting tumor recurrence. Although chest wall reconstruction surgery may be followed by a combination of local radiotherapy to clear residual cancer cells and prevent BC recurrence [3,4], endowing prostheses with their anti-tumor capabilities is a promising strategy. Because of the intrinsic bio-inertness, titanium-based materials cannot perform satisfactory biological functions.…”

Section: Introductionmentioning

confidence: 99%

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Li,

Liu,

Shi

et al. 2023

Biomed. Mater.

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The chest wall is the most frequent metastatic site of breast cancer (BC) and the metastasis usually occurs in a solitary setting. Chest wall resection is a way to treat solitary BC metastasis, but intraoperative bone defects and local tumor recurrence still affect the life quality of patients. Titanium-based prostheses are widely used for chest wall repair and reconstruction, but their inherent bio-inertness makes their clinical performance unfavorable. Nanostructured surfaces can give titanium substrates the ability to excellently modulate a variety of cellular functions. Ascorbic acid is a potential stimulator of tumor suppression and osteogenic differentiation. An ascorbic acid-decorated nanostructured titanium surface was prepared through alkali treatment and spin-coating technique and its effects on the biological responses of BC cells and osteoblasts were assessed. The results exhibited that the nanorod structure and ascorbic acid synergistically inhibited the proliferation, spreading, and migration of BC cells. Additionally, the ascorbic acid-decorated nanostructured surface significantly promoted the proliferation and osteogenic differentiation of osteoblasts. This work may provide valuable references for the clinical application of titanium materials in chest wall reconstruction after the resection of metastatic BC.

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“…In most cases, titanium alloy steel plate is used to repair the defect of chest wall. However, although the titanium plate can maintain the stability of the chest wall, but it affects the subsequent radiotherapy (2,3). In the aspect of perforator vascular anastomosis of flap, the thoracic and thoracoacromial vessel are generally selected as the receiving region.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of the chest wall in locally advanced breast cancer with multi-disciplinary cooperation: a case report of mesh repair plus TRAM combined with DIEP chest wall reconstruction

et al. 2020

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Locally advanced breast cancer, which is defined as a malignant breast tumor that invades or adheres to the surrounding tissue, is characterized by the invasion of the chest wall and the skin surface by the tumor. Multiple lymph nodes are invaded and fuse into a mass, causing extensive axillary lymph node metastasis. However, locally advanced breast cancer does not exhibit distant metastasis. At present, in most hospitals in China and the rest of the world, this type of breast cancer is primarily managed through systematic and local treatments. However, a consensus concerning the optimal surgical method for chest wall reconstruction, which for many surgeons is a difficult and confusing procedure, has not been reached.In the past, many breast centers had used skin flap combined with hard mesh titanium alloy plate to repair the large chest wall defects. Although titanium alloy plate can maintain the stability of the chest wall, it may have a negative effect on the follow-up radiotherapy of breast cancer patients, which is a controversial method. In addition, titanium alloy mesh also has the risk of deformation and fracture. These factors will cause some hidden dangers to patient safety. According to the research, the soft mesh not only has the characteristics of satisfactory compatibility and robustness for maintaining the stability of chest wall, but also does not affect the postoperative radiotherapy of patients. Combined with the advantages of soft mesh, Our department treated a case of locally advanced breast cancer with chest wall invasion. Through cooperation between the breast surgery and thoracic surgery departments, a mesh repair plus transverse rectus abdominis myocutaneous (TRAM) combined with deep inferior epigastric perforator (DIEP) procedure was performed to remove the breast tumor and repair the large area of skin defect after surgery, and a relatively satisfactory therapeutic effect was achieved. In this case, we took two novel approaches: first, a 4-layer high-density polyethylene mesh was used to repair the defect; secondly, the inferior epigastric artery perforation was anastomosed with the thoracoacromial artery (end-to-end anastomosis) and the inferior epigastric vein perforation was anastomosed with the axillary vein (end-to-side anastomosis).

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Value of Porous Titanium Alloy Plates for Chest Wall Reconstruction after Resection of Chest Wall Tumors

Cited by 5 publications

References 32 publications

Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line

Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Reconstruction of the chest wall in locally advanced breast cancer with multi-disciplinary cooperation: a case report of mesh repair plus TRAM combined with DIEP chest wall reconstruction

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