INTRODUCTIONThe sensory and motor innervation of the upper limb is via three nerves originating from the brachial plexus -the ulnar, radial and median nerves. Ultrasound (US) of the forearm can effectively reveal structural abnormalities and variants of the median nerve. Bifid median nerve, defined as high division of the median nerve proximal to the carpal tunnel, is a variation of nerve anatomy first described by Lanz in 1977 and has an incidence of 2.8%.
1,2The forearm and hand are supplied by radial and ulnar arteries, however the median artery (accompanying the median nerve) normally regresses in the early embryonic period.3 Persistence of the median artery, demonstrated effectively by colour doppler, is commonly associated with bifid median nerve. 4 The median nerve is supplied by epineural, interfascicular, and intrafascicular vascular plexuses that link to one another and form a free vascular network. Vascular compromise involving the median nerve in ABSTRACT Background: Patients with high division of the median nerve proximal to carpal tunnel, or bifid median nerve, may present with carpal tunnel syndrome (CTS). Ultrasound (US) measurements indicative of CTS in this subset of patients differ from those in patients with non-bifid median nerve. The objectives were to evaluate the parameter ∆CSA [difference between the maximum cross-sectional area of bifid median nerve within carpal tunnel (CSAc) and outside tunnel (CSAp)] in the diagnosis of CTS, to compare sensitivity and specificity of ∆CSA with nerve conduction velocity studies (NCS), and to compare the cross-sectional area (CSAc, CSAp & ∆CSA) of bifid median nerve in CTS patients with that in asymptomatic controls. Methods: 20 wrists with bifid median nerves and symptoms suggestive of CTS were included in the study group. Nerve conduction velocity studies (NCS) were performed in all cases. 4 wrists of asymptomatic age-matched subjects had bifid median nerves and normal NCS and were included in the control group. High resolution ultrasonography was performed for all wrists and findings documented. Statistical Analysis: Receiver Operating Characteristics curves were used to obtain the level of significance (p-value) and assessment of correlation between ∆CSA and NCS findings. Results: There was significant correlation between ∆CSA and NCS. A cut-off value of 2.3mm 2 gave the best calculated sensitivity (76.9 %) and specificity (100%). Conclusions: CSA criteria for diagnosing CTS in patients with bifid median nerves are different from those in patients with non-bifid median nerve. ∆CSA is a sensitive and specific parameter for confirming the diagnosis of CTS in patients with bifid median nerve with sensitivity approaching that of NCS.