Value of prenatal ultrasound and magnetic resonance imaging in assessment of congenital primary cytomegalovirus infection

Lipitz, Shlomo; Hoffmann, Chen; Feldman, Baruch; Tepperberg-Dikawa, M; Schiff, Eyal; Weisz, Boaz

doi:10.1002/uog.7657

Cited by 87 publications

(93 citation statements)

References 22 publications

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“…Similarly, the combination of targeted US examination and MRI in the third trimester in known infected fetuses provides with a 95% sensitivity on the identification of CNS lesions related to CMV infection. Lipitz et al [89] have also shown that the outcome of congenital primary CMV infection with normal prenatal US and MRI examinations is favorable. On the contrary, Manara et al [90] have shown that, among 14 symptomatic CMV-infected children, white matter involvement was very variable and unrelated to the clinical course, while cortical development and ventriculomegaly were associated to a poor outcome except SNHL.…”

Section: Resultsmentioning

confidence: 99%

Management of Pregnancies with Confirmed Cytomegalovirus Fetal Infection

Benoist

Leruez‐Ville

et al. 2013

Fetal Diagn Ther

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Systematic screening for cytomegalovirus (CMV) maternal infection is not recommended in most countries. Nevertheless, primary CMV infection will occur in around 1% of women. The vertical transmission rate is estimated to be around 30-50%. Newborns with congenital CMV infection remain asymptomatic in the majority of cases and around 10% will present with a wide range of abnormalities. Fetal infection can be diagnosed by amniocentesis with amplification of the viral genome in the amniotic fluid by polymerase chain reaction. This prenatal diagnosis is mainly performed when ultrasound abnormalities are observed. The purpose of this mini-review is to describe the management options when a fetus is known to be infected.

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Section: Resultsmentioning

confidence: 99%

Management of Pregnancies with Confirmed Cytomegalovirus Fetal Infection

Benoist

Leruez‐Ville

et al. 2013

Fetal Diagn Ther

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“…All were infected in the first or second trimester. Three cohort studies in the literature reported a good short-term prognosis for infants with these characteristics 17 22 23…”

Section: Discussionmentioning

confidence: 97%

Follow-up of infants with congenital cytomegalovirus and normal fetal imaging

Amir

Atias

Linder

et al. 2016

Arch Dis Child Fetal Neonatal Ed

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“…This is in concordance with previous studies: Gindes et al 5 found a high transmission rate of 75% in 28 pregnancies after gw 25 and all 20 live-born congenitally infected infants were healthy. Lipitz et al 6 reported that all 8 children infected during the third trimester of pregnancy were asymptomatic at birth and later. In the third study Foulon et al 7 investigated sensorineural hearing loss (SNHL) in 28 congenitally infected infants in relation to onset of primary maternal infection.…”

Section: Discussionmentioning

confidence: 98%

“…The risk of symptomatic congenital infection was mainly connected with maternal first and second trimester infection. [5][6][7][8][9] …”

Section: Introductionmentioning

confidence: 98%