Value of renal biopsy in acute intrinsic renal failure.

Renal Biopsy in Patients Aged 65 Years and Older: A Clinicopathological Analysis

“…That might be the reason many authors think clinical clues are sufficient to identify the underlying pathology in older patients with acute renal injury. However, clinical studies have revealed discrepancies between clinicalbased diagnosis and histopathological diagnosis in these patients (8,9,12). These studies suggest that renal biopsy may be useful to identify renal parenchymal pathology in the elderly after ruling out the pre-and post-renal etiologies for acute renal dysfunction (8,9,12).…”

“…However, clinical studies have revealed discrepancies between clinicalbased diagnosis and histopathological diagnosis in these patients (8,9,12). These studies suggest that renal biopsy may be useful to identify renal parenchymal pathology in the elderly after ruling out the pre-and post-renal etiologies for acute renal dysfunction (8,9,12). Haas et al reported that the histopathological findings were pauci-immune crescentic glomerulonephritis (31.2%), acute tubulointerstitial nephritis (18.6%), acute tubular necrosis (14.2%) and benign nephrosclerosis (3.2%) (9) in 259 (24.3%) patients 60 years old and older among 4264 patients with acute renal injury between years 1991 and 1998.…”

Successful Steroid Therapy for Cefdinir-induced Acute Tubulointerstitial Nephritis with Progressive Renal Failure.

“…Therefore, vigilance for this complication is important when any cephalosporin is administered. The frequently mentioned triad of fever, skin rash, and eosinophilia is seen in less than one-third of cases of acute tubulointerstitial nephritis (4,6); the only definitive diagnostic test is renal biopsy. The pathologic findings in the present case were compatible for this disorder (7).…”

Akute interstitielle Nephritiden

“…1) können allenfalls die Vermutung nahe legen, sie sind jedoch häufig nicht charakteristisch. So ergaben bereits vor 25 Jahren Biopsien bei unerklärtem akutem Nierenversagen in 8-14% eine akute interstitielle Nephritis, die meist klinisch nicht vermutet worden war [2,3]. Insgesamt findet sich in 2-3% aller Nierenbiopsien eine akute interstitielle Nephritis [4,5].…”