Value of Repeat Brain MRI in Children with Focal Epilepsy and Negative Findings on Initial MRI

Jeon, Tae Yeon; Kim, Ji Hye; Lee, Jeehun; Yoo, So-Young; Hwang, Sook Min; Lee, Munhyang

doi:10.3348/kjr.2017.18.4.729

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…In total, 50 KJR (9101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354565758), 492 ER, and 254 Radiology articles reported original research studies analyzing patient data. Of these, 44 (88%; 95% CI: 75.8–94.8%) (910121314151617181920212324262728293031323435363738394041424344474849505152535455565758), 359 (73%; 95% CI: 68.9–76.7%), and 211 (83.1%; 95% CI: 78–87.2%) articles, respectively, revealed the start and end of data collection to the level of calendar month.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 44 (88%; 95% CI: 75.8–94.8%) (910121314151617181920212324262728293031323435363738394041424344474849505152535455565758), 359 (73%; 95% CI: 68.9–76.7%), and 211 (83.1%; 95% CI: 78–87.2%) articles, respectively, revealed the start and end of data collection to the level of calendar month. The point estimate value of this proportion was slightly larger in KJR than in ER and Radiology, although the difference was not statistically significant.…”

Section: Resultsmentioning

confidence: 99%

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Age of Data in Contemporary Research Articles Published in Representative General Radiology Journals

2018

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ObjectiveTo analyze and compare the age of data in contemporary research articles published in representative general radiology journals.Materials and MethodsWe searched for articles reporting original research studies analyzing patient data that were published in the print issues of the Korean Journal of Radiology (KJR), European Radiology (ER), and Radiology in 2017. Eligible articles were reviewed to extract data collection period (time from first patient recruitment to last patient follow-up) and age of data (time between data collection end and publication). The journals were compared in terms of the proportion of articles reporting the data collection period to the level of calendar month and regarding the age of data.ResultsThere were 50, 492, and 254 eligible articles in KJR, ER, and Radiology, respectively. Of these, 44 (88%; 95% confidence interval [CI]: 75.8–94.8%), 359 (73%; 95% CI: 68.9–76.7%), and 211 (83.1%; 95% CI: 78–87.2%) articles, respectively, provided enough details of data collection period, revealing a significant difference between ER and Radiology (p = 0.002). The age of data was significantly greater in KJR (median age: 826 days; range: 299–2843 days) than in ER (median age: 570 days; range: 56–4742 days; p < 0.001) and Radiology (median age: 618; range: 75–4271 days; p < 0.001).ConclusionKorean Journal of Radiology did not fall behind ER or Radiology in reporting of data collection period, but showed a significantly greater age of data than ER and Radiology, suggesting that KJR should take measures to improve the timeliness of its data.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Age of Data in Contemporary Research Articles Published in Representative General Radiology Journals

2018

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“…High-resolution MRI may demonstrate subtle findings, including the "transmantle" sign involving white matter signal abnormalities extending toward the ependymal surface of the ventricle. 5,8,32,41,46,48,49 While many articles have described imaging findings of MCD, few reports have explored the impact of age and cerebral development on the radiographic depiction of MCD.…”

Section: Special Considerations In Neuroradiologymentioning

confidence: 99%

“…Therefore, repeat imaging beyond 24-30 months of age is warranted for infants with DRE and initial unremarkable MRI and may elucidate a previously occult FCD. 5,28,41 Given these nuances, radiographic interpretation should (The images were obtained in a child who underwent repeated screening for atypical teratoid rhabdoid tumor due to a known SMARCB1 genetic mutation risk factor.) Initially the cortex appears hypo-intense compared to white matter, but the white matter becomes hypo-intense as myelination continues.…”

Section: Special Considerations In Neuroradiologymentioning

confidence: 99%

Preoperative evaluation and surgical management of infants and toddlers with drug-resistant epilepsy

Pindrik

Hoang

Smith

et al. 2018

Neurosurgical Focus

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OBJECTIVEDespite perioperative risks, epilepsy surgery represents a legitimate curative or palliative treatment approach for children with drug-resistant epilepsy (DRE). Several factors characterizing infants and toddlers with DRE create unique challenges regarding optimal evaluation and management. Epilepsy surgery within children < 3 years of age has received moderate attention in the literature, including mainly case series and retrospective studies. This article presents a systematic literature review and explores multidisciplinary considerations for the preoperative evaluation and surgical management of infants and toddlers with DRE.METHODSThe study team conducted a systematic literature review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, targeting studies that investigated children < 3 years of age undergoing surgical treatment of DRE. Using the PubMed database, investigators selected peer-reviewed articles that reported seizure outcomes with or without developmental outcomes and/or perioperative complications. Studies were eliminated based on the following exclusion criteria: sample size < 5 patients; and inclusion of patients > 3 years of age, when demographic and outcomes data could not be separated from the cohort of patients < 3 years of age.RESULTSThe study team identified 20 studies published between January 1990 and May 2017 that satisfied eligibility criteria. All selected studies represented retrospective reviews, observational studies, and uncontrolled case series. The compiled group of studies incorporated 465 patients who underwent resective or disconnective surgery (18 studies, 444 patients) or vagus nerve stimulator insertion (2 studies, 21 patients). Patient age at surgery ranged between 28 days and 36 months, with a mean of 16.8 months (1.4 years).DISCUSSIONThe study team provided a detailed summary of the literature review, focusing on the etiologies, preoperative evaluation, surgical treatments, seizure and developmental outcomes, and potential for functional recovery of infants and toddlers with DRE. Additionally, the authors discussed special considerations in this vulnerable age group from the perspective of multiple disciplines.CONCLUSIONSWhile presenting notable challenges, pediatric epilepsy surgery within infants and toddlers (children < 3 years of age) offers significant opportunities for improved seizure frequency, neuro-cognitive development, and quality of life. Successful evaluation and treatment of young children with DRE requires special consideration of multiple aspects related to neurological and physiological immaturity and surgical morbidity.

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“…This adversely affects prognosis and presents difficulties for surgical resection ( 69 ). The most common underlying pathologies identified are FCDs, gliosis, hamartomas, and hippocampal sclerosis, with the rest being negative for any histopathological abnormality ( 70 71 ). Invasive EEG monitoring before surgical resection can be aided by prior non-invasive lateralization or localization.…”

Section: Structural Mri-negative Epilepsymentioning

confidence: 99%

The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion

et al. 2018

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Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Similar to single-photon emission computed tomography, its utility in epilepsy is based on alterations in perfusion linked to seizure activity by neurovascular coupling. In this article, we discuss complementary value that ASL can provide in the evaluation and characterization of some basic substrates underlying epilepsy. We also discuss the role that ASL may play in sMRI negative epilepsy and acute scenarios such as status epilepticus.

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Value of Repeat Brain MRI in Children with Focal Epilepsy and Negative Findings on Initial MRI

Cited by 19 publications

References 25 publications

Age of Data in Contemporary Research Articles Published in Representative General Radiology Journals

Age of Data in Contemporary Research Articles Published in Representative General Radiology Journals

Preoperative evaluation and surgical management of infants and toddlers with drug-resistant epilepsy

The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion

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