Value of semen culture in the diagnosis of chronic bacterial prostatitis: A simplified method

Alba, A. Budía; Palmero, J.L.; Broseta, Enrique; Tejadillos, Susana; Benedicto, Antonio; Queipo, Jose; Gobernado, M; Cruz, João

doi:10.1080/00365590600748247

Cited by 53 publications

(36 citation statements)

References 17 publications

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“…These reports demonstrated the efficacy of semen analysis in detecting pathogens that cause CBP. However, with one exception, Reference [39], in these studies semen analysis was investigated as an alternative to prostatic massage in the context of a modified four-glass test npg [26] or as an alternative to traditional segmented tests as a whole [13]. Our study indicates that, rather than representing a diagnostic alternative, semen culture and analysis can complement traditional four-or two-glass assays to detect an increased number of pathogens.…”

Section: Discussionmentioning

confidence: 97%

“…Some authors have proposed that failure to detect bacterial infection in a number of prostatitis patients responding symptomatically to antibacterial treatment is because of the insufficient sensitivity of currently available LUT segmented tests [13]. Recently, a number of published studies focused on semen culture and analysis in CP patients [13,26,38,39].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a number of published studies focused on semen culture and analysis in CP patients [13,26,38,39]. These reports demonstrated the efficacy of semen analysis in detecting pathogens that cause CBP.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have suggested that segmented tests do not display sufficient sensitivity and may underestimate the prevalence of bacterial prostatitis cases, thus misdirecting the therapeutic approach to the disease [13,14]. In addition to segmented tests, other procedures are adopted in the prostatitis diagnostic workup.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Budía and coworkers [13] have published the results of a study performed on 895 patients who met the consensus criteria for clinical CP/CPPS, showing that semen has higher sensitivity than an expressed prostatic secretion (EPS) sample for the diagnosis of CBP. Thus, culture and microbiological analysis of semen might increase the number of patients diagnosed with bacterial disease and decrease the number of subjects classified by exclusion into category III CP/CPPS.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications

Magri¹,

Wagenlehner²,

Montanari³

et al. 2009

Asian J Androl

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The significance and diagnostic value of semen analysis in chronic bacterial prostatitis has been extensively debated and remains controversial. To investigate the diagnostic relevance of semen culture in the bacteriological workup of prostatitis patients, we retrospectively analyzed a clinical database of 696 symptomatic patients. All patients were routinely subjected to a four-glass test, followed by semen culture and analysis. This allowed to dissect from the database three different diagnostic scenarios, and to compare the 'two-glass' pre-/post-massage test and the standard 'four-glass' test with a 'five-glass' test (four-glass plus post-VB3 semen culture). The 'five-glass' test showed 3.6-or 6.5-fold increases in relative sensitivity and lesser reductions (-13.2% or -14.7%) in relative specificity for traditional uropathogens (TUs) compared with the four-glass or two-glass test, respectively. The area under the ROC curve and Jouden's index were increased, whereas positive and negative likelihood ratios were lower than comparators, indicating that the 'five-glass' assay may be superior in confirming the negative outcome of both standard tests. The five-, four-, and two-glass tests detected TUs (Enterobacteriaceae, Enterococci, etc.) in 120, 33, and 20 patients and unusual pathogens (Streptococci, other Gram-positive species, Mycoplasmata, and others) in 130, 56, and 45 patients, respectively. When patients were subjected to pharmacological treatment, including a combination of a fluoroquinolone and a macrolide, no differences in eradication rates were observed between groups diagnosed with different tests, irrespective of pathogen category. Eradication was associated with long-term sign/symptom remission; no significant intergroup differences in sign/symptom scores were observed throughout a 24-month off-therapy follow-up period. In conclusion, our data support the usefulness of semen analysis in the diagnostic workup of prostatitis patients when this test is used to complement the four-glass Meares and Stamey test. Improvement of microbiological assays conveys important diagnostic and therapeutic implications.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications

Magri¹,

Wagenlehner²,

Montanari³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

show abstract

Diagnosis and management of prostatitis: a urological challenge

Attar

Hamid

Peters

2007

Trends Urology, Gynecol. Sexual Health

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Therapy in Oligozoospermia (Varicocele, Cryptorchidism, Inflammation, and Seminal Tract Infections)

Busetto

Saleh

Gül

et al. 2022

Practical Clinical Andrology

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The management of infertile men with varicocele is highly debated. Varicocele repair (VR) can be either surgical (varicolectomy) or through angiographic embolization. Surgical repair of varicocele includes open non-microsurgical techniques whether inguinal (Ivanissevich) or high retroperitoneal ligation (Palomo), open microsurgical techniques (inguinal or sub-inguinal) or laparoscopic. The accumulating evidence suggests that VR can improve conventional sperm parameters (sperm concentration, motility, and morphology), seminal oxidative stress, sperm DNA fragmentation, and serum testosterone concentrations.Treatment of cryptorchism is based on surgical correction. The surgical approach for palpable undescended testis is inguinal orchidopexy with eventual repair of concomitant hernia. Scrotal surgical approach is a viable alternative. For nonpalpable undescended testis, surgical approach can be open or laparoscopic, in one or two stages and possibly with spermatic vessel transection. In some cases, orchiectomy is required (testis abdominal localization, impossibility of mobilization or high neoplastic risk).Male accessory gland infections, including infection and/or inflammation of accessory glands (prostate, seminal vesicles, and Cowper’s glands), and male genital tract infections are characterized by the presence of an elevated number of leukocytes and/or pathogens in semen, together with inflammatory signs. Management is based on different antibiotic therapies.

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Value of semen culture in the diagnosis of chronic bacterial prostatitis: A simplified method

Abstract: A semen sample has higher sensitivity than an EPS for the diagnosis of bacterial chronic prostatitis. In our clinical work-up, first-void urine and a semen culture are considered the only tests necessary to diagnose chronic prostatitis.

Cited by 53 publications

References 17 publications

Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications

Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications

Diagnosis and management of prostatitis: a urological challenge

Therapy in Oligozoospermia (Varicocele, Cryptorchidism, Inflammation, and Seminal Tract Infections)

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