Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study

Su, Longxiang; Han, Bingchao; Liu, Changting; Liang, Liling; Jiang, Zhaoxu; Deng, Jiexin; Peng, Yan; Jia, Yuhua; Feng, Dan; Xie, Lixin

doi:10.1186/1471-2334-12-157

Cited by 102 publications

(82 citation statements)

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“…For instance, C-reactive protein (CRP), a systemic marker of the acute phase inflammatory response, has been measured in saliva and serum, and can differentiate periodontal health from periodontal disease, as its levels are elevated in disease (Christodoulides et al, 2005;D'Aiuto et al, 2004). When compared to CRP or procalcitonin, a marker that can differentiate between infectious and non-infectious inflammation, serum and urine sTREM-1 shows higher sensitivity and specificity for detecting systemic inflammation in early bacterial sepsis (Su et al, 2012). In this respect, sTREM-1 could well serve as a biomarker representative of the inflammatory state of the infected periodontal tissues.…”

Section: Discussionmentioning

confidence: 99%

“…This has been well demonstrated in systemic sepsis (Gibot et al, 2004a;Gibot et al, 2004b;Su et al, 2012), arthritis (Collins et al, 2009;Murakami et al, 2007), pulmonary infections (Ruiz-Gonzalez et al, 2011), pancreatitis (Yasuda et al, 2008) and inflammatory bowel disease (Park et al, 2009). sTREM-1 is a biomarker that can easily be measured in biological fluids (Skogstrand et al, 2005).…”

Section: The Engagement Of Trem-1 In In Vivomentioning

confidence: 99%

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Elevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitis

et al. 2012

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The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. The hypothesis of this study was that oral and systemic levels of sTREM-1 are elevated in periodontitis. Therefore, the aim was to investigate, by ELISA, the sTREM-1 concentrations in saliva and serum of individuals without periodontitis (control) and persons with chronic or generalized aggressive periodontitis. In saliva, sTREM-1 concentrations were higher in chronic and aggressive periodontitis than in the control group, by 3.3-fold and 5.6-fold, respectively. In serum, these differences were 1.7-fold and 2-fold, respectively. However, there were no significant differences between the two forms of periodontitis, neither in saliva nor in serum. Salivary and serum sTREM-1 levels positively correlated with full-mouth clinical periodontal parameters. In conclusion, the increased oral and systemic levels of sTREM-1 in periodontitis denote a value for this molecule as a biomarker for the disease and may also have implications in the association between periodontal infections and systemic inflammatory response. ABSTRACTThe Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection, and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. The hypothesis of this study is that oral and systemic levels of sTREM-1 are elevated in periodontitis. Therefore, the aim was to investigate by ELISA the sTREM-1 concentrations in saliva and serum of nonperiodontitis subjects (control) and patients with chronic or generalized aggressive periodontitis. In saliva, sTREM-1 concentrations were higher in chronic and aggressive periodontitis than the control group, by 3.3-fold and 5.6-fold, respectively.In serum, these differences were 1.7-fold and 2-fold, respectively. However, there were no significant differences between the two forms of periodontitis, neither in saliva nor in serum. Salivary and serum sTREM-1 levels positively correlated with full mouth clinical periodontal parameters. In conclusion, the increased oral and systemic levels of sTREM-1 in periodontitis denote a value for this molecule as a biomarker for the disease, and may also have implications in the association between periodontal infections and systemic inflammatory response.3

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Section: Discussionmentioning

confidence: 99%

Section: The Engagement Of Trem-1 In In Vivomentioning

confidence: 99%

Elevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitis

et al. 2012

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“…Cytokines have been widely assessed as potential biomarkers of sepsis severity. Studied cytokines have included procalcitonin (PCT), C-reactive protein (CRP), and interleukin (IL)-6, which reflect the inflammatory state in sepsis (Assicot et al 1993;Lobo et al 2003;Carlyn et al 2015), as well as soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) (Su et al 2012) and IL-10 (Matera et al 2013). Unfortunately, all of these cytokines lack sufficient specificity to enable accurate prognostic judgment.…”

Section: Introductionmentioning

confidence: 99%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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Sepsis is a systemic host response to infection, and patients with sepsis are frequently handled in the intensive care unit. However, mortality related to sepsis remains high throughout the world. In addition, there have been no efficient prognostic biomarkers for sepsis to be employed in clinical practice. We therefore aimed to identify prognostic biomarkers for sepsis using the chemokine/cytokine array. This study included 143 patients with sepsis, who were divided into survivor and nonsurvivor groups according to their 28-day mortality status. The cytokine array analysis was performed with plasma samples from two randomly selected patients in each sepsiofgroup. We thus identified seven cytokines with significantly and consistently different expression levels between nonsurvivors and survivors. The validity of the selected cytokines was then assessed by enzyme-linked immunosorbent assay (ELISA). We finally found monocyte chemoattractant protein 1 (MCP-1) as the most useful biomarker to distinguish the two sepsis groups; namely, non-surviving patients (n = 56) exhibited significantly higher plasma concentrations of MCP-1 compared to survivors (n = 87). MCP-1 is a CC chemokine, a potent chemoattractant that contributes to systemic inflammatory response syndrome. Areas under the receiver operating characteristic curves for prediction of 28-day mortality were 0.763 for MCP-1, 0.680 for the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score, 0.64 for the Sequential Organ Failure Assessment (SOFA) score, 0.621 for procalcitonin, and 0.785 for MCP-1 plus APACHE II score. In conclusion, we propose that plasma MCP-1 is a useful biomarker in predicting outcome of sepsis.

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“…Although several studies documented the role of serum level of sTREM-1 in diagnosis of neonatal sepsis (Su et al, 2012;Saldir et al, 2015), there is insufficient data regarding its prognostic value in neonatal sepsis. Hence, our study aimed at investigating the role of serum levels of sTREM-1 in early diagnosis and prognosis of LOS.…”

Section: Int J Adv Res 4(8) 123-131 124mentioning

confidence: 99%

SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

El-khier¹,

Nassar²,

AbdElAal³

et al. 2016

IJAR

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Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study

Cited by 102 publications

References 50 publications

Elevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitis

Elevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitis

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

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