Value of Strain Elastography Ultrasound in Differentiation of Breast Masses and Histopathologic Correlation

Atabey, Aysun Okar; Arıbal, Erkin; Ergelen, Rabia; Kaya, Hakan

doi:10.5152/tjbh.2014.2331

Cited by 9 publications

(14 citation statements)

References 21 publications

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“…The above findings are almost similar to the current study. In another study by [3] done on 96 patients, where the mean age of their patients was 50 years with ranged varied from 19 to 87 years, which is higher with the present study.…”

Section: Methodscontrasting

confidence: 71%

“…As suggested by the American Cancer Society, breast self-examination and clinical breast examination (palpation) are the most frequently used diagnostic tools for detecting breast abnormalities [2]. Breast screening and diagnostic breast imaging also provide early diagnosis of breast cancer [3]. Mammography, the primary screening modality for breast cancer detection, has a sensitivity of 67.8% and an accuracy of 0.70 as described in Berg et al However, its sensitivity drops from 100% in fatty breasts to about 45% for extremely dense breasts.…”

Section: Introductionmentioning

confidence: 99%

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Value of Strain Elastography Ultrasound in Differentiation of Benign and Malignant Breast Masses with Histopathological Correlation

Moonmoon

Bony²,

Islam³

et al. 2020

JCTI

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Introduction: Breast cancer is currently one of the leading causes of cancer deaths in women. Early detection and accurate classification of suspicious masses as benign or malignant is important for arriving at an appropriate treatment plan. Elastography has shown potential in differentiating benign from malignant breast tumors. Objective: To evaluate the usefulness of Strain Elastography ultrasound in differentiation of benign and malignant breast masses taken histopathology as Gold Standard. Methods: This cross-sectional study was carried out in the Department of Radiology and Imaging, BIRDEM, Dhaka, from July 2017 to June 2019. A total of 92 female patients with breast masses were enrolled in this study. Strain Elastography Ultrasound and histopathology were done in all these patients. Statistical analyses of the results were obtained by using window-based computer software devised with Statistical Packages for Social Sciences (SPSS-22). Results: The validity test of B-mode ultrasonography for differentiation of benign and malignant breast mass has sensitivity 95.0%, specificity 71.2%, accuracy 81.5% and positive predictive value 71.7% and negative predictive value 94.9%. Strain Score has sensitivity 85.0%, specificity 92.3%, accuracy 89.1%, positive predictive value 89.5% and negative predictive value 88.9%. Strain ratio has sensitivity 87.5%, specificity 94.2%, accuracy 91.3%, positive predictive value 92.1% and negative predictive value 90.7%. The validity test of Combined (B-mode sonography and Elastography) has sensitivity 97.5%, specificity 96.2%, accuracy 96.7%, positive predictive value 95.1% and negative predictive value 98.0%. The areas under the curve (AUCs) from the receiver operating characteristic (ROC) curves were 0.948 for ACR-BIRADS classification, 0.986 for Strain Score, 0.956 for Strain Ratio and 0.990 for combination. Conclusion: The combination of strain elastography with B-mode ultrasonography has the potential to improve the differentiation of benign and malignant breast masses.

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Section: Methodscontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Value of Strain Elastography Ultrasound in Differentiation of Benign and Malignant Breast Masses with Histopathological Correlation

Moonmoon

Bony²,

Islam³

et al. 2020

JCTI

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“…Besides the technical factors in acquiring elastography data, histological make up of breast lesions can also influence the ES and SR values. 24 In our study, some of the benign lesions with a significant amount of fibrosis showed high ES > 3 and high strain ratios above our cut-off value 3, thereby leading to false positive results. False negative results on ES were three and SR were four (Table 3).…”

Section: Discussionmentioning

confidence: 52%

Added value of strain elastography in the characterisation of breast lesions: A prospective study

Sinha¹,

Sharma²,

Kundaragi

et al. 2020

Ultrasound

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Background Elastography is a new promising ultrasonographic technique which is used to differentiate benign and malignant breast lesions based on the stiffness of the lesion. Purpose To determine the role of strain elastography in characterisation of breast lesions and to compare the diagnostic performances of strain elastography and conventional ultrasound (US). Methods In total, 113 breast lesions in 100 women were prospectively evaluated by US and strain elastography followed by the histopathological examination. Elastography score based on the Tsukuba colour scale and strain ratio were determined for each lesion. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were calculated for each modality and the diagnostic performances were compared. The best cut-off point was calculated for each of the elastography parameters using the receiver operator curve analysis. Results Out of the 113 lesions, 40 were malignant (35.4%) and 73 were benign (64.6%). The area under the curve for elastography score showed significant difference with that of US: 0.98 versus 0.90 (Difference = 0.08, p =0.02). The elastography parameters were more specific as compared to US (ES-95 and SR-93% vs. 63%, p < 0.05) with a high negative predictive value. The combined use of elastography and US gave better results with 95% sensitivity, 94% specificity, 94% accuracy and negative predictive value reaching 97%. Conclusion Strain elastography is a useful adjunct to conventional ultrasonography. The combined use of strain elastography and ultrasound improves the characterisation of breast lesions and helps in down-staging of assigned BI-RADS category, thereby avoiding unnecessary biopsies. ES is the most useful elastography parameter to differentiate between benign and malignant breast lesions.

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“…In addition to the technical factors, histopathological makeup of the breast lesions can also influence the ES and SR values,[ 24 ] contributing to the false-positive or false-negative results on elastography. In our study, there were 27 false-positive lesions on conventional ultrasonography, 5 on strain ratio, and 4 on ES [ Table 4 ].…”

Section: Discussionmentioning

confidence: 99%

Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study

Sinha¹,

Kundaragi²,

Sharma³

et al. 2020

Indian Journal of Radiology and Imaging

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Purpose: To evaluate the role of strain elastography (SE) in reclassification of indeterminate breast lesions placed under BIRADS 3 and 4 categories by conventional ultrasound (US) parameters so as to recourse biopsy only for suspicious stiffer lesions. Methods: 113 breast lesions in 100 women assigned as BIRADS category 3 and 4 on US parameters were prospectively evaluated by SE followed by histo-pathological examination. Strain ratio (SR) and Elastography Score (ES) were determined for each lesion. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each modality and diagnostic performance were compared. The best cut-off point was calculated for each of the elastography parameter using the receiver operator curve analysis (ROC). Results: Out of the 113 lesions, 40 were malignant (35.4%) and 73 were benign (64.6%). A statistically significant difference was observed in the AUC for ES and conventional US: 0.98 vs 0.90 (Difference = 0.08, P = 0.02). Elastography parameters were more specific as compared to US (ES-94.5 & SR-93.2% vs 63%, P < 0.05) with high NPV. SE performed better in BIRADS 4 category lesions. On the basis of elastography parameters, 85% of BIRADS 4 category lesions were correctly predicted as benign with overall sensitivity, specificity and diagnostic accuracy of elastography being 97%, 84.6% and 91.9%. Among BIRADS 3 category lesions, 97% were correctly predicted as benign and 50% lesions were correctly predicted as malignant with a sensitivity of 50%, specificity of 97.8% and diagnostic accuracy of 94%. Conclusion: Strain elastography is a useful adjunct to conventional ultrasonography for the assessment of indeterminate breast lesions and may help in avoiding unnecessary follow ups and biopsies. Elastography score is a better parameter as compared to strain ratio.

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Value of Strain Elastography Ultrasound in Differentiation of Breast Masses and Histopathologic Correlation

Cited by 9 publications

References 21 publications

Value of Strain Elastography Ultrasound in Differentiation of Benign and Malignant Breast Masses with Histopathological Correlation

Value of Strain Elastography Ultrasound in Differentiation of Benign and Malignant Breast Masses with Histopathological Correlation

Added value of strain elastography in the characterisation of breast lesions: A prospective study

Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study

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