2018
DOI: 10.3892/ol.2018.9049
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Value of systemic PET/CT in the diagnosis and differential diagnosis of aplastic anemia

Abstract: The aim of the present study was to investigate the value of systemic [F]fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in the diagnosis and differential diagnosis of aplastic anemia (AA). Systemic PET/CT imaging results of 24 patients diagnosed with AA in The First Affiliated Hospital of Sun Yat-Sen University between May 2011 and August 2014 were retrospectively analyzed and compared with results from healthy individuals and patients with acute leukemia (AL) or myelodysplastic… Show more

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Cited by 7 publications
(10 citation statements)
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“… 14 Positron emission tomography/computed tomography (PET/CT) examination has shown low bone metabolism in AA patients, which could be used for differential diagnosis from atypical MDS. 27 However, PET/CT is expensive and requires injections of radioactive agents. Quantitative analysis of bone marrow fat (BMF) content through IDEAL‐IQ imaging allows for the detection of abnormal changes in the bone marrow.…”
Section: Discussionmentioning
confidence: 99%
“… 14 Positron emission tomography/computed tomography (PET/CT) examination has shown low bone metabolism in AA patients, which could be used for differential diagnosis from atypical MDS. 27 However, PET/CT is expensive and requires injections of radioactive agents. Quantitative analysis of bone marrow fat (BMF) content through IDEAL‐IQ imaging allows for the detection of abnormal changes in the bone marrow.…”
Section: Discussionmentioning
confidence: 99%
“…16 In patients with aplastic anemia, a recent study described three different types of [18F]FDG-PET manifestations, including normal BM metabolism, generalized hypometabolism, and diffuse hypometabolism associated with focal hyperproliferation. 17 As for the latter, the inhomogeneous BM metabolism and patchy distribution of [18F] FDG uptake (also described elsewhere in case reports [18][19][20] ) most frequently occurs in the vertebral bodies, sternum and iliac bones. 17 The spots probably indicate residual compensatory hyperplastic hematopoietic islands in an otherwise aplastic BM 17,20 and are associated with an active phase of the disease.…”
Section: Discussionmentioning
confidence: 80%
“…17 As for the latter, the inhomogeneous BM metabolism and patchy distribution of [18F] FDG uptake (also described elsewhere in case reports [18][19][20] ) most frequently occurs in the vertebral bodies, sternum and iliac bones. 17 The spots probably indicate residual compensatory hyperplastic hematopoietic islands in an otherwise aplastic BM 17,20 and are associated with an active phase of the disease. The patchy [18F]FDG distribution seems to persist even in patients in remission after immunosuppressive therapy.…”
Section: Discussionmentioning
confidence: 80%
“…Diffuse 18F-FDG uptake significantly increased in the bone marrow, liver and spleen. The SUVmax values in the bone marrow, liver, and spleen were 6.6, 5.3, and 4.6, respectively, and these values were higher than those measured in healthy people who underwent whole-body 18F-FDG-PET/CT examination at our hospital [ 8 ] ( Figure 5 ).
Figure 5.
…”
Section: Resultsmentioning
confidence: 88%