Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

Abstract

Background: To evaluate the utility of non-invasive parameters driving from T1 mapping on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) compared with diffusion-weighted imaging (DWI).Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was included in the retrospective study, who underwent preoperative gadoxetic acid-enhanced MRI combined with DWI and T1 mapping. Parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and ADC values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters.Results: The mean value of postcontrast T1 relaxation time were significantly higher in MVI-positive HCCs that MVI-negative HCCs (621.0 vs. 536.5, P <0.001). MVI-positive HCCs demonstrated significantly lower reduction rates of T1 relaxation time and lower ADC values than MVI-negative HCCs (39.4% vs 49.9, P<0.001; 1.495×10-3mm2/s vs 1.620×10-3mm2/s, P=0.003, respectively). The area under receiver operating characteristic curves were 0.587, 0.728, 0.824 and 0.690 for precontrast, postcontrast, reduction rate of T1 relaxation time and ADC, respectively. The reduction rate of T1 relaxation time was the most reliable feature with sensitivity, specificity and accuracy of the cut-off value (44.9%) of 79.0%, 73.2%, 75.5%, respectively.Conclusions: Reduction rate of T1 relaxation time on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

The Value of CT Perfusion Parameters and Apparent Diffusion Coefficient Value of Magnetic Resonance Diffusion Weighted Imaging in Diagnosis of Hepatocellular Carcinoma

“…DWI has been gradually used for the diagnosis of abdominal disease. In liver disease, it is mainly used for the identification of lesions and the judgment of benign and malignant lesions in the early stage [15,16]. This study aims to explore the value of CT perfusion parameters and MRI-DWI ADC in the diagnosis of hepatocellular carcinoma.…”

Preoperative Evaluation of Gd‐EOB‐DTPA‐Enhanced MRI Radiomics‐Based Nomogram in Small Solitary Hepatocellular Carcinoma (≤3 cm) With Microvascular Invasion: A Two‐Center Study

“…It has been reported in the literature that imaging features such as peritumoral hypointensity on hepatobiliary phase (HBP), peritumoral enhancement, unsmooth tumor margins, and a low apparent diffusion coefficient (ADC) value are noninvasive imaging biomarkers for evaluating MVI 9–12 . Furthermore, several quantitative MRI methods, such as intravoxel incoherent motion and T1 mapping, have been applied to the preoperative evaluation of MVI in HCC 13,14 . However, the abovementioned measures are subjective or lack adequate validation to MVI evaluation 15 …”

“…[9][10][11][12] Furthermore, several quantitative MRI methods, such as intravoxel incoherent motion and T1 mapping, have been applied to the preoperative evaluation of MVI in HCC. 13,14 However, the abovementioned measures are subjective or lack adequate validation to MVI evaluation. 15 Radiomics are essential for interpreting cancer phenotypes and tumor microenvironment through high-throughput extraction of medical image features and subsequent analyses of a large amount of advanced quantitative imaging features.…”