Value of the Metastatic Lymph Node Ratio for Predicting the Prognosis of Non‐Small‐Cell Lung Cancer Patients

Wang, Chang Li; Li, Yue; Yue, Dong; Zhang, Lian Min; Zhang, Zhen Fa; Sun, Bing

doi:10.1007/s00268-011-1360-8

Cited by 43 publications

(39 citation statements)

References 30 publications

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“…However, because they are a heterogeneous group with different clinicopathological features, patients with pN2 IIIA NSCLC would likely benefit from individualized treatments. Several clinical and pathological factors, including the number of pathologically involved lymph node (LN) stations [14, 15], positive lymph node ratio (LNR) [16–20], extra-capsular extension (ECE) [21], and LN skip status [22], are predictive of prognosis in NSCLC patients and should be considered when weighing the risks and benefits of PORT, which induces damage. It is particularly important to examine multiple factors when predicting patient outcomes and the therapeutic efficacy of PORT; no single factor is sufficiently accurate for such evaluations.…”

Section: Discussionmentioning

confidence: 99%

Nomograms for predicting progression and efficacy of post-operation radiotherapy in IIIA-pN2 non-small cell lung cancer patients

et al. 2017

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In this retrospective study, we developed nomograms for predicting the efficacy of post-operation radiotherapy (PORT) in IIIA-N2 non-small cell lung cancer (NSCLC) patients. In total, 334 patients received post-operational chemotherapy and were included in the analysis. Of those, 115 also received either concurrent or sequential post-operational radiotherapy (PORT). Nomograms were developed using Cox proportional hazard regression models to identify clinicopathological characteristics that predicted progression free survival (PFS) and overall survival (OS), and subgroup analyses of the effects of PORT were performed using nomogram risk scores. PFS and OS predicted using the nomogram agreed well with actual PFS and OS, and patients with high PFS/OS nomogram scores had poorer prognoses. In subgroup analyses, PORT increased survival more in patients with low PFS nomogram risk scores or high OS nomogram risk scores. Thus, our novel nomogram risk score model predicted PFS, OS, and the efficacy of PORT in IIIA-N2 NSCLC patients.

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Section: Discussionmentioning

confidence: 99%

Nomograms for predicting progression and efficacy of post-operation radiotherapy in IIIA-pN2 non-small cell lung cancer patients

et al. 2017

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“…The heterogeneity of NSCLC involves multiple factors, including preoperative detection, neoadjuvant therapy susceptibility, clinically unsuspected N2 disease (the presence of ipsilateral mediastinal nodal metastases), and the level or site and number, or both, of involved mediastinal lymph nodes [1, 3]. Few reports have evaluated the lymph node ratio (LNR) as a prognostic factor for N1 and N2 NSCLC [4, 5]. Therefore we investigated the correlation between LNR and prognosis in patients with pathological N2 NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Lymph node ratio as a prognostic factor in patients with pathological N2 non-small cell lung cancer

et al. 2016

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BackgroundThe aim of this study was to investigate whether the lymph node ratio (LNR) was associated with the prognosis of patients, who underwent surgery for pathological N2 non-small cell lung cancer (NSCLC).MethodsA total of 182 patients were diagnosed with pathological N2 disease and underwent complete resection surgeries with systematic lymphadenectomies. We counted the number of positives and removed lymph nodes to calculate a ratio between them (LNR). We also investigated the association between skip mediastinal lymph node metastasis and survival.ResultsUnivariate analysis of survival in patients with N2 NSCLC showed that the T factor, clinical N factor, and LNR were significant prognostic factors. Multivariate analyses showed that the clinical N stage and LNR were significant independent prognostic factors for patients with pathological N2 NSCLC. Patients with a clinical lymph node status of 0 (cN0) and LNR ≤0.22 showed a significantly higher survival rate than patients with a cN1-2 and LNR ≥0.22 and 5-year survival rates were 47.1 and 10.3%, respectively (p < 0.0001).ConclusionsLNR is an important prognostic factor for poor outcome following surgery in patients with N2 disease. The combination of the LNR and cN status provides a valuable prognostic tool.

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“…Wang et al showed that metastatic lymph node ratio greater than 0.18 is a poor prognostic factor among stage II-IIIa patients. [32] In our study, we found that N2 patients with metastatic lymph node ratio greater than 0.4 had poor overall survival. Generally, the more extensive is the tumor spread in the mediastinum lymph node, the more unoptimistic the prognosis would be.…”

Section: Discussionmentioning

confidence: 67%

Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer

Hsieh

Liu

et al. 2015

Biomed J

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Value of the Metastatic Lymph Node Ratio for Predicting the Prognosis of Non‐Small‐Cell Lung Cancer Patients

Abstract: The combination of the LNR and pN status provides a valuable help with prognosis. However, these results must be evaluated further in a large prospective randomized clinical trial.

Cited by 43 publications

References 30 publications

Nomograms for predicting progression and efficacy of post-operation radiotherapy in IIIA-pN2 non-small cell lung cancer patients

Nomograms for predicting progression and efficacy of post-operation radiotherapy in IIIA-pN2 non-small cell lung cancer patients

Lymph node ratio as a prognostic factor in patients with pathological N2 non-small cell lung cancer

Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer

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