Value of tissue harmonic imaging (THI) and contrast harmonic imaging (CHI) in detection and characterisation of breast tumours

Clevert, D.‐A.; Jung, Ernst-Michael; Jungius, Karl-Peter; Ertan, Kubilay; Kubale, R.

doi:10.1007/s00330-006-0325-z

Cited by 23 publications

(9 citation statements)

References 42 publications

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“…Nowadays, ultrasound technology offers promising developments such as CEUS [17][18][19][20][21][22][23]. In our experience the use of sonographic contrast agent tends to increase the sensitivity of the ultrasound examination, overcoming some of its ** The colors are visible in the on-line version of the article.…”

Section: Discussionmentioning

confidence: 99%

Multislice computed tomography versus contrast-enhanced ultrasound in evaluation of complex cystic renal masses using the Bosniak classification system

Clevert

Minaifar

Weckbach

et al. 2008

Clinical Hemorheology and Microcirculation

129

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To assess the diagnostic performance of multislice computed tomography (MS-CT) in the classification of atypical or complex cystic renal masses using the Bosniak system in comparison to contrast-enhanced ultrasound (CEUS) and, in unclear cases, to the surgery findings.Thirty-two consecutive patients (14 women, 18 men; age range 39-72 years) with 37 atypical or complex cystic renal masses at MS-CT underwent conventional ultrasound (US) and CEUS. CEUS employed a low-MI technique using 1.6-2.4 ml SonoVue (Bracco, Italy) i.v. and a 2-4 MHz multifrequency transducer (Siemens, Sequoia, Acuson). Fourteen masses were resected, the remaining 23 lesions were followed up for periods ranging from 3 months to 2 years. Images and digital cine clips of all lesions were evaluated by blinded readers. On the basis of MS-CT appearance the lesions were assigned to the Bosniak classification. Similar criteria modified for US imaging were used to score atypical cysts at CEUS.In the Bosniak classification at MS-CT the lesions were scored as category II (n = 15), IIF (n = 7), III (n = 8) and IV (n = 7). At CEUS, masses were classified as Bosniak classification II (n = 8), IIF (n = 12), III (n = 8) or IV (n = 9). All type IV and 6/8 type III and 1/8 type IIF lesions were removed surgically. All category IV and 3/8 category III lesions of the surgical group were malignant, the one type IIF lesion was benign. All class II and IIF cysts except one were stable after a follow-up period ranging from 3 months to 2 years. In 7/37 lesions (19%) the MS-CT and CEUS scores were different, while in 30/37 (81%) they were equivalent. CEUS depicted more thin septa than MS-CT, or upgraded wall thickness, resulting in a Bosniak score upgrade from category II to IIF in 5 lesions. Two cystic renal masses could not be clearly assigned by MS-CT but were considered malignant due to the additional information from CEUS, which was confirmed by surgical removal (small cystic renal cancer).CEUS with SonoVue allows an early evaluation of atypical or complex cystic renal masses. It is an additional examination to MS-CT. Due to the dynamic examination, additional information about perfusion of the cystic septa or cystic renal cancer can be gained.

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Section: Discussionmentioning

confidence: 99%

Multislice computed tomography versus contrast-enhanced ultrasound in evaluation of complex cystic renal masses using the Bosniak classification system

Clevert

Minaifar

Weckbach

et al. 2008

Clinical Hemorheology and Microcirculation

129

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“…However, these problems have been partially overcome with the analysis of clips and the help of quantitative software [18]. Clevert et al [19] investigated the value of tissue harmonic imaging (THI) and contrast harmonic imaging (CHI) for the detection and characterization of breast tumors. They used additional Doppler methods to analyze breast tumor vascularity, and the detection of penetrating or central vessels proved to be an accurate sign of malignancy.…”

Section: Characterization Of Breast Lesions Reported In the Literaturementioning

confidence: 99%

Contrast-Enhanced Ultrasound Examination of the Breast: A Literature Review

et al. 2012

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Angiogenesis is the basis for neoplastic growth in human tissues. Nevertheless, neovascularization may be present both in benign and malignant lesions. Although microvascular density assessment is a useful tool for the study of neoplastic vascularization, it cannot be used on a large scale because of the invasiveness of the method. When contrast-enhanced ultrasonography (CEUS) was introduced in clinical practice, the initial results in the field of breast lesions were disappointing because differentiation between benign and malignant masses was not possible. Magnetic resonance imaging (MRI) assessment of the microvascular features was therefore immediately accepted because of the higher diagnostic accuracy. However, in the last decade the sensitivity and specificity of CEUS have greatly improved due to the development of more sophisticated ultrasound (US) equipment, the introduction of second-generation contrast agents and the development of dedicated software able to perform quantitative analysis. This literature review compares the main results reported in the literature regarding the use of CEUS for the characterization of neoplastic lesions of the breast. All the authors agreed that malignant lesions show early wash-in with more intense enhancement and fast wash-out in comparison with benign masses. However, there is still no observer agreement regarding vascularization patterns, and different classifications are proposed. The conclusion of this literature review is therefore that the clinical role of CEUS in the diagnostic process and in follow-up is still to be clearly defined.

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“…Although the current literature does not yet offer vast experience of the quantitative evaluation of breast masses, the application of CE-US in the senology field is a diagnostic practice that is increasingly widely used with promising results [16][17][18][19][20][21][22]; CE-US would, indeed, appear to be a reliable technique in the characterisation of breast masses on account of its ability to explore the vascular pattern, with good correlation with the same kind of evaluation conducted using breast MRI.…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI

Caproni

Marchisio²,

Pecchi

et al. 2009

Eur Radiol

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Value of tissue harmonic imaging (THI) and contrast harmonic imaging (CHI) in detection and characterisation of breast tumours

Cited by 23 publications

References 42 publications

Multislice computed tomography versus contrast-enhanced ultrasound in evaluation of complex cystic renal masses using the Bosniak classification system

Multislice computed tomography versus contrast-enhanced ultrasound in evaluation of complex cystic renal masses using the Bosniak classification system

Contrast-Enhanced Ultrasound Examination of the Breast: A Literature Review

Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI

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