Value of transbronchial needle aspiration combined with a rapid on-site evaluation of cytology in the diagnosis of pulmonary lesions

Liang, Long; Duan, Hongxia; Zhu, Hongzi; Yang, Haojie; Li, Xuan; Wang, Changhui; Xie, Shuanshuan

doi:10.3389/fmed.2022.922239

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Observations on 328 cases revealed that the ROSE and the ultimate cytologic diagnoses agreed on 91.6% of lymph nodes ( p < .001) 10 . Liang et al analyzed 260 cases with lung masses, nodules, cavities, and inflammatory lesions who underwent EBUS‐TBNA with ROSE ( n = 134) or without ROSE ( n = 126) 11 . The specificity, sensitivity, NPV (negative predictive value) and PPV (positive predictive value) of the ROSE‐guided EBUS‐TBNA were 96.9, 97.4, 98.90% and 92.5, respectively 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Liang et al analyzed 260 cases with lung masses, nodules, cavities, and inflammatory lesions who underwent EBUS‐TBNA with ROSE ( n = 134) or without ROSE ( n = 126) 11 . The specificity, sensitivity, NPV (negative predictive value) and PPV (positive predictive value) of the ROSE‐guided EBUS‐TBNA were 96.9, 97.4, 98.90% and 92.5, respectively 11 . In our study, we obtained similar fidelities with 90,2%, 93,1%, 94,8%, 87,1%, and 91,4% rates for sensitivity, specificity, PPV, NPV, and accuracy, respectively.…”

Section: Discussionmentioning

confidence: 99%

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EBUS ROSE‐guided cytological evaluations of intrathoracic lesions. Assessments of the pathological material adequacy and the diagnostic efficacy

Silav

Çıkrıkçıoğlu²,

Aydemir

et al. 2023

Diagnostic Cytopathology

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Background Several clinical groups consider cytological assessment under EBUS (Endobronchial Ultrasonography)‐ROSE (Rapid Onsite Evaluation) as the golden standard for diagnosis and staging of intrathoracic lesions. On the other hand, some investigators proposed that EBUS‐TBNA (Transbronchial Needle Aspiration) has considerably high false‐negative rates for diagnosis. In this study, we analyzed our patient cohort (n = 152) with intrathoracic lesions and suspected malignancies evaluated by EBUS‐ROSE. Our specific aims were: (i) to determine whether EBUS‐ROSE could provide sufficient pathologic material for diagnosis and staging; (ii) to determine the fidelity of EBUS‐ROSE‐guided initial diagnoses in comparison to paraffin block diagnoses; (iii) to evaluate whether anatomical localization of sampled lymph nodes associate with material adequacy and final diagnoses. Methods NCSS (Number Cruncher Statistical System) 2020 Statistical Software (Utah, USA) was used for statistical analysis. Results In EBUS‐ROSE cytological assessment, material adequacy was determined in 50,7% (n = 77) of the cases. Considering the paraffin block pathology as the golden standart, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rates of EBUS‐ROSE were 90,2%, 93,1%, 94,8%, 87,1%, and 91,4%, respectively. There was no statistically significant difference between the final pathology and EBUS cytology results (p > .05) with a non‐random Kappa agreement rate as 82.9%. There were differences in material adequacy and diagnoses according to the localization of sampled lymph node stations. Conclusions EBUS‐ROSE is efficient to decide for the adequacy of the pathological specimen and provides diagnoses with reliable fidelity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

EBUS ROSE‐guided cytological evaluations of intrathoracic lesions. Assessments of the pathological material adequacy and the diagnostic efficacy

Silav

Çıkrıkçıoğlu²,

Aydemir

et al. 2023

Diagnostic Cytopathology

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Diagnostic performance of rapid on‐site evaluation during bronchoscopy for lung cancer: A comprehensive meta‐analysis

Chen,

Lu,

Chang

et al. 2024

Cancer Cytopathology

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BackgroundLung cancer is the leading cause of cancer‐related mortality worldwide. Screening high‐risk populations for lung cancer with low‐dose computed tomography (LDCT) reduces lung cancer mortality. Bronchoscopy is a diagnostic procedure used to monitor patients suspected of having lung cancer after LDCT. Rapid on‐site evaluation (ROSE) can improve the diagnostic accuracy of endobronchial ultrasound–guided transbronchial needle aspiration (EBUS‐TBNA), although its diagnostic value remains unclear. In this meta‐analysis, the authors evaluated the diagnostic accuracy of ROSE during bronchoscopy.MethodsThe PubMed, Embase, and Cochrane Library databases were searched for studies evaluating the diagnostic accuracy of ROSE for lung cancer during bronchoscopy. Studies evaluating the performance of ROSE and articles providing sufficient data for constructing a 2 × 2 table on a per‐lesion basis were included. A meta‐analysis was conducted using a bivariate random‐effects model.ResultsIn total, 32 studies involving 8243 lung lesions were included with a pooled sensitivity of 91.8% and a pooled specificity of 94.9%. Subgroup analysis of 12 studies involving 2929 specimens from patients who underwent computed tomography revealed a pooled sensitivity of 93.8% and a pooled specificity of 96%. Further subgroup analysis of seven studies on the diagnostic outcomes of ROSE for intrathoracic or mediastinal lymph nodes through EBUS‐TBNA for lung cancer staging revealed a pooled sensitivity of 90.1% and a pooled specificity of 96.9%.ConclusionsROSE exhibited high sensitivity and specificity for diagnosing lung cancer during bronchoscopy. It also exhibited high sensitivity in detecting lung cancer in patients undergoing LDCT and higher specificity for nodal staging with EBUS‐TBNA.

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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): revolutionizing the landscape of lung disease diagnostics

Yamamoto,

Nakayama

2023

J Med Ultrasonics

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Value of transbronchial needle aspiration combined with a rapid on-site evaluation of cytology in the diagnosis of pulmonary lesions

Cited by 3 publications

References 34 publications

EBUS ROSE‐guided cytological evaluations of intrathoracic lesions. Assessments of the pathological material adequacy and the diagnostic efficacy

EBUS ROSE‐guided cytological evaluations of intrathoracic lesions. Assessments of the pathological material adequacy and the diagnostic efficacy

Diagnostic performance of rapid on‐site evaluation during bronchoscopy for lung cancer: A comprehensive meta‐analysis

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): revolutionizing the landscape of lung disease diagnostics

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