Value of transient elastography for the prediction of variceal bleeding

Abstract

LS measurement by means of TE is a reliable noninvasive method for the detection of EV and for the prediction of variceal bleeding.

Liver Stiffness Measurement by Fibroscan Predicts the Presence and Size of Esophageal Varices in Egyptian Patients with HCV Related Liver Cirrhosis

“…In agreement with our results Sporea I et al, [19] studied 1000 patients with TE and showed more or less equivalent cut off values (For the presence of varices, the optimal Fibroscan cut-off was 31 kPa and for bleeding cut-off was 50.7 KPa), according to Lebrec [20]; the larger the size of varices the higher risk of bleeding and according to Sporea [19] study cut off value for TE to predict risk of bleeding could be considered as cut off value for prediction of large varices. Moreover, studies carried out by Vizzutti et al, [21] a cutoff value for prediction of varices was 17.6 kPa, these cut off values are smaller than we obtained, but the different demographics and patients characteristics as well as the type of fibroscan machines could be the reason for these discrepancy.…”

New reliability criteria for transient elastography increase the number of accurate measurements for screening of cirrhosis and portal hypertension

“…Thus, in clinical practice TE is increasingly used as a rapid and non-invasive and easy repeatable tool to assess liver fibrosis (9)(10)(11)(12)(13)(14) and portal hypertension (15)(16)(17)(18)(19) in various aetiologies of CLD. Furthermore, TE may be used to estimate prognosis (20)(21)(22) or to predict the presence of gastroesophageal varices (23,24). Previous studies showed that several factors, such as sex (25), levels of aminotransferases (26,27), histological necroinflammation (28,29), extrahepatic cholestasis (30,31), liver steatosis (28,(32)(33)(34), body mass index (BMI) (35,36), fasting state (37,38) and central venous pressure (39) might all influence results of TE measurements.…”

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

“…Liver fibrosis and GEV have a strong correlation. Many reports to date have described the utility of serum fibrosis markers or imaging techniques in estimating GEV [24][25][26][27][28]. Although serum markers, including the FIB-4 index, APRI, platelet count, and AAR, are simple, the diagnostic accuracy in estimating GEV is not sufficient [29].…”