Value of Ultrasound Elastography in the Differential Diagnosis of Cervical Lymph Nodes

Acu, Leyla; Oktar, Suna Özhan; Acu, Ruşen; Yücel, Cem; Cebeci, Süleyman

doi:10.7863/ultra.15.09019

Cited by 27 publications

(37 citation statements)

References 20 publications

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“…In a study by Acu et al . [ 25 ], the strain index from ultrasound images classified benign and malignant cervical LNs with a sensitivity, specificity, and accuracy of 71.6%, 76.5%, and 75.0%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Ardakani¹,

Rasekhi²,

Mohammadi³

et al. 2018

Pol J Radiol

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PurposePapillary thyroid carcinoma (PTC) is the most common thyroid cancer, and cervical lymph nodes (LNs) are the most common extrathyroid metastatic involvement. Early detection and reliable diagnosis of LNs can lead to improved cure rates and management costs. This study explored the potential of texture analysis for texture-based classification of tumour-free and metastatic cervical LNs of PTC in ultrasound imaging.Material and methodsA total of 274 LNs (137 tumour-free and 137 metastatic) were explored using the texture analysis (TA) method. Up to 300 features were extracted for texture analysis in three normalisations (default, 3sigma, and 1-99%). Linear discriminant analysis was employed to transform raw data to lower-dimensional spaces and increase discriminative power. The features were classified by the first nearest neighbour classifier.ResultsNormalisation reflected improvement on the performance of the classifier; hence, the features under 3sigma normalisation schemes through FFPA (fusion Fisher plus the probability of classification error [POE] + average correlation coefficients [ACC]) features indicated high performance in classifying tumour-free and metastatic LNs with a sensitivity of 99.27%, specificity of 98.54%, accuracy of 98.90%, positive predictive value of 98.55%, and negative predictive value of 99.26%. The area under the receiver operating characteristic curve was 0.996.ConclusionsTA was determined to be a reliable method with the potential for characterisation. This method can be applied by physicians to differentiate between tumour-free and metastatic LNs in patients with PTC in conventional ultrasound imaging.

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Section: Discussionmentioning

confidence: 99%

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Ardakani¹,

Rasekhi²,

Mohammadi³

et al. 2018

Pol J Radiol

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“…Many prospective and retrospective studies concerning the strain elastography of cervical lymph nodes have been conducted. 3 4 12 13 14 15 Lyshchik et al 12 indicated that sonoelastography had a high accuracy for differentiating benign and metastatic cervical lymph nodes in patients suspected of having thyroid or hypopharyngeal cancer. Alam et al 13 showed that the combination of highly specific elastography with highly sensitive conventional B-mode sonography had the potential to further improve the diagnosis of metastatic enlarged cervical lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…However, Lo et al 15 showed that qualitative real-time elastography offered no additional value over conventional ultrasound in predicting malignancy in cervical lymph nodes. Acu et al 3 reported that ultrasound elastography added no additional value to combined B-mode and color Doppler sonography for differentiating between benign and malignant cervical lymph nodes. Shingaki et al 11 showed that intraoral strain elastography could be an alternative noninvasive method for diagnosing tongue carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…It is a novel and dynamic imaging technique that is simply based on the elasticity or stiffness of tissues or organs under manual light compression and decompression using a conventional ultrasonography machine with special software and a conventional ultrasonography probe. 2 3 4 Preliminary strain elastography data have been generally promising; it has been shown to yield moderately high accuracy for malignancies in several locations within the body, 5 6 7 because malignancies in general are stiffer than benign pathologies and normal tissues. 8 …”

Section: Introductionmentioning

confidence: 99%

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Strain elastography of tongue carcinoma using intraoral ultrasonography: A preliminary study to characterize normal tissues and lesions

et al. 2018

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PurposeThe aim of this study was to evaluate the quantitative strain elastography of tongue carcinoma using intraoral ultrasonography.Materials and MethodsTwo patients with squamous cell carcinoma (SCC) who underwent quantitative strain elastography for the diagnosis of tongue lesions using intraoral ultrasonography were included in this prospective study. Strain elastography was performed using a linear 14 MHz transducer (Aplio 300; Canon Medical Systems, Otawara, Japan). Manual light compression and decompression of the tongue by the transducer was performed to achieve optimal and consistent color coding. The variation in tissue strain over time caused by the compression exerted using the probe was displayed as a strain graph. The integrated strain elastography software allowed the operator to place circular regions of interest (ROIs) of various diameters within the elastography window, and automatically displayed quantitative strain (%) for each ROI. Quantitative indices of the strain (%) were measured for normal tissues and lesions in the tongue.ResultsThe average strain of normal tissue and tongue SCC in a 50-year-old man was 1.468% and 0.000%, respectively. The average strain of normal tissue and tongue SCC in a 59-year-old man was 1.007% and 0.000%, respectively.ConclusionWe investigated the quantitative strain elastography of tongue carcinoma using intraoral ultrasonography. Strain elastography using intraoral ultrasonography is a promising technique for characterizing and differentiating normal tissues and SCC in the tongue.

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“… 1 Strain elastography with ultrasonography is a relatively new imaging technique that has been found to be effective for the differential diagnosis of cervical lymph node metastasis. 2 3 In recent years, strain elastography of the tongue has been found to be effective for differentiating healthy tissues and squamous cell carcinoma (SCC). 4 5 …”

Section: Introductionmentioning

confidence: 99%

Usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases

et al. 2018

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PurposeTo evaluate the usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases.Materials and MethodsTen patients with oral and maxillofacial diseases and 28 volunteers drawn from our student doctors were examined by shear wave elastography with a 14-MHz linear transducer using an Aplio 300 apparatus (Canon Medical Systems, Otawara, Japan). A statistical analysis of the shear elastic modulus (kPa) of healthy tissue (the sublingual gland, submandibular gland, anterior belly of the digastric muscle, and geniohyoid muscle) in the 28 volunteers was performed using 1-way repeated measures analysis of variance with the Tukey honest significant difference test. The maximum shear elastic modulus (kPa) of 8 patients with squamous cell carcinoma (SCC) and 2 patients with benign lesions was evaluated with the Mann-Whitney U test. The analysis used a 5% significance level.ResultsThe mean shear elastic modulus of the sublingual gland (9.4±3.7 kPa) was lower than that of the geniohyoid muscle (19.2±9.2 kPa, P=.000) and the anterior belly of the digastric muscle (15.3±6.1 kPa, P=.004). The maximum shear elastic modulus of the SCCs (109.6±14.4 kPa) was higher than that of the benign lesions (46.4±26.8 kPa, P=.044).ConclusionOur results demonstrated the usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases. Shear wave elastography has the potential to be an effective technique for the objective and quantitative diagnosis of oral and maxillofacial diseases.

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Value of Ultrasound Elastography in the Differential Diagnosis of Cervical Lymph Nodes

Abstract: Ultrasound elastography adds no additional value to combined B-mode and color Doppler sonography for differentiation of benign and malignant cervical lymph nodes.

Cited by 27 publications

References 20 publications

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis

Strain elastography of tongue carcinoma using intraoral ultrasonography: A preliminary study to characterize normal tissues and lesions

Usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases

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