Value of Urinary Endothelin-1 in Patients with Primary Vesicoureteral Reflux

Komeyama, Takeshi; Takeda, Masayuki; Katayama, Yasushi; Tsutsui, Toshiki; Mizusawa, Takaki; Takahashi, Hitomi; Hatano, Akihiko; Obara, Kenji; Sato, Shotaro

doi:10.1159/000187560

Cited by 14 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was speculated that these elevated ET1 levels are the result of circulating plasma factors (eg, LPS and ST) that stimulate its production by endothelial and/or renal epithelial cells. However, as elevated urinary ET excretion has been observed in other glomerular dis eases 109 and patients with renal tubular injury, 110 its spe cific role in HUS awaits further evaluation.…”

Section: Pathogenesismentioning

confidence: 98%

Hemolytic Uremic Syndromes in Childhood

Gordjani

Sutor²,

Zimmerhackl³

et al. 1997

Semin Thromb Hemost

View full text Add to dashboard Cite

The hemolytic uremic syndrome (HUS) comprises hemolytic anemia, acute renal failure, and thrombocytopenia. It is the most frequent cause of acute renal failure in childhood. Ninety percent of the patients have a diarrheal prodrome, and are referred to as having typical HUS. Approximately 10% exhibit the so-called atypical HUS. Typical HUS is caused by shigatoxin-producing Escherichia coli. The toxin, bound to the globotriosyl ceramide cell receptor and internalized, interferes with protein synthesis, predominantly of endothelial cells. The main target is the kidney, but nearly every organ system can be involved. The most common extrarenal involvement is damage to the central nervous system. The central event is probably an insult to the endothelial cell with consecutive loss of antithrombogenic properties. The von Willebrand factor, activation of platelets via platelet-activating factor, other growth factors (e.g., interleukins 1, 6, 8), nitric oxide, lipopolysaccharides, activated polymorphonucleated neutrophils, and the metabolites of the arachidonic acid cascade (e.g., prostaglandin I2) are believed to be involved in the pathogenic cascade. Controlled therapeutic trials with heparin, dipyridamole, aspirin, and urokinase have not been associated with improved outcome. Antibiotics have not yielded any benefit. Plasma infusions and plasma exchange appear to be efficacious, and are justified in cases of atypical HUS and thrombotic thrombocytopenic purpura. Binding of the toxin to the intestinal lumen, and thereby inhibition of enteral reabsorption, is under investigation.

show abstract

Section: Pathogenesismentioning

confidence: 98%

Hemolytic Uremic Syndromes in Childhood

Gordjani

Sutor²,

Zimmerhackl³

et al. 1997

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…In patients with vesicoureteral reflux (VUR) high levels of urinary β2-microglobulin, N-acetyl-β-D-glucosaminidase, and microalbumin have been reported [78]. Komeyama et al [79] found no correlation between any of these factors and the renal ET-1/creatinine ratio in spot urine samples, both in adults and in children, in agreement with our results [63]; however ET-1/creatinine increased in proportion to the grade of reflux, except for grade 5 reflux where it was decreased. Thus ET-1 may be an indicator of renal tubular injury in patients with primary VUR.…”

Section: Et Excretion In Tubular Disturbances (Diabetic Ketoacidosismentioning

confidence: 99%

Renal excretion of endothelin in children

Máttyus

Zimmerhackl

Schwarz

et al. 1997

Pediatric Nephrology

View full text Add to dashboard Cite

Endothelin (ET) is a peptide with profound vasoconstrictive potential. First isolated from porcine endothelial cell supernatant, it is produced also by smooth muscle, epithelial and circulating cells. Besides vasoconstriction, a wide spectrum of biological activities of ET (via activation of membrane receptors) has been described. These include regulation of other hormones and neurotransmitters, cellular growth and proliferation, bronchoconstriction, and, in the kidney, natriuresis and water diuresis. ET exerts its effects mainly in an autocrine and paracrine fashion. A high concentration of ET is found in urine, compared with plasma originating mainly from the kidney itself. In this review we focus on the role of urinary excretion of ET in children. ET excretion was determined under different physiological and pathological conditions. In premature infants and newborns, the daily excretion of ET (corrected for body surface) was higher than in older children; it was constant, and comparable to the values in healthy adults after the age of 2 years. Renal ET excretion correlated positively with urine flow in both healthy and sick children. Conditions with tubular and/or collecting duct cell damage, such as severe hypoxia, hemolytic-uremic syndrome, renal transplantation, diabetes mellitus, chronic renal failure, and contrast media cytotoxicity were characterized by elevated urinary excretion of ET. In conclusion, the renal excretion of ET is influenced by several factors, probably reflecting the intrarenal ET production. ET has a low specificity with regard to renal injury.

show abstract

“…In reflux group, there was no correlation between endothelin levels and age and gender. Two research works stated that urinary endothelin-1 excretion in patients with primary VUR was significantly higher than normal, and it increased in proportion to the grade of reflux (4,5). However, based on dimercaptosuccinic acid (DMSA) uptake, they did not find any relationship between endothelin level and renal parenchymal and function damage (4,5).…”

Section: Discussionmentioning

confidence: 99%

The level of urinary endothelin in patients with urinary reflux

Azarfar¹,

Esmaeeli²,

Naseri³

et al. 2017

J Nephropathol

View full text Add to dashboard Cite

Background:In different tissues, the endothelin is produced by vascular endothelium. They are potent vasoconstrictor peptides. There is a little information about the role of endothelin in reflux nephropathy. Objectives: The aim of this study is to evaluate urinary levels of endothelin in patients with vesicoureteral reflux (VUR). Patients and Methods: It was a cross-sectional study that conducted on 81 children who received voiding cystourethrogram (VCUG). Based on VCUG reports, patients were divided into two groups; with reflux (40 persons) and without reflux (41 persons). We got a urine sample from patients with mid-stream or urine bag method. The endothelin level was assessed with ELISA immunoassay. Data was analyzed using SPSS 16. Results: Based on VCUG reports, 40 patients (49.4%) had urinary reflux, of them 20 cases suffered from unilateral urinary reflux and others from bilateral. Of 40 patients with reflux, 23 cases (57.5% of reflux group) had kidney scar and seven individuals (17.5%) had abnormal kidney sonography. Of patients with urinary reflux, 13 cases (32.5%) had grade1 urinary reflux, 8 cases (20%) grade 2, and 5 cases (12.5%) grade 3 and finally 14 cases (35%) grade 4. The UET-1 levels were significantly higher in VUR patients compared to the control group (P < 0.001). Comparison of mean endothelin levels between two groups was done using Mann-Whitney U test and was statistically significance (P < 0.001). We used Kruskal-Wallis for comparison of endothelin levels in different grades of reflux (P < 0.001). Conclusions: Urine endothelin-1 level can be considered as an alternative to VCUG for screening vesicourethral reflux. ABSTRACT Implication for health policy/practice/research/medical education:Urine endothelin-1 level can be considered as an alternative to VCUG for screening VUR. According to significant changes in the different grades of reflux, it is helpful in determining the severity of VUR. It can at least prevent performing unnecessary VCUG in low-risk patients. Please cite this paper as: Azarfar A, Esmaeeli M, Naseri M, Badiee Aval S, Ghanee Sharbaf F, Ravanshad S, et al. The level of urinary endothelin in patients with urinary reflux.

show abstract

Value of Urinary Endothelin-1 in Patients with Primary Vesicoureteral Reflux

Cited by 14 publications

References 11 publications

Hemolytic Uremic Syndromes in Childhood

Hemolytic Uremic Syndromes in Childhood

Renal excretion of endothelin in children

The level of urinary endothelin in patients with urinary reflux

Contact Info

Product

Resources

About