Value of urinary KIM-1 and NGAL combined with serum Cys C for predicting acute kidney injury secondary to decompensated cirrhosis

Lei, Lei; Li, Liang Ping; Zeng, Zhen; Mu, Jing; Yang, Xue; Zhou, Chao; Wang, Zhi Lan; Hu, Zhang

doi:10.1038/s41598-018-26226-6

Cited by 73 publications

(63 citation statements)

References 19 publications

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“…According to our analysis of changes in renal function‐related indicators within one week after transplantation, we found that both serum and urinary NGAL have the same downward trend as creatinine and β2‐MG, and they have the opposite trend of eGFR, which was consistent with other studies 18‐20 . In the first week after renal transplantation, serum and urinary NGAL, creatinine, and β2‐MG increased, while eGFR decreased.…”

Section: Discussionsupporting

confidence: 89%

Urinary neutrophil gelatinase‐associated lipocalin rapidly decreases in the first week after kidney transplantation

Wang

et al. 2020

Clinical Laboratory Analysis

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Background Recipient delayed graft function, which is defined as dialysis in the first week after transplantation, is one of the most common early complications after kidney transplantation. This study aimed to evaluate the daily changes in renal function‐related biomarkers in the first week post‐transplant. Methods A total of 72 kidney transplant recipients were retrospectively included in this study. Clinical and laboratory data were collected daily during the first week post‐transplant, including urinary concentrations of neutrophil gelatinase‐associated lipocalin (NGAL), serum concentrations of NGAL, creatinine, urea nitrogen, uric acid (UA), β2‐microglobulin, cystatin C, and estimated glomerular filtration rate (eGFR). Results There were no significant differences in urea nitrogen (P = .375), UA (P = .090), and cystatin C (P = .691), while urinary NGAL (P < .0001), serum NGAL (P < .0001), creatinine (P < .0001), β2‐microglobulin (P < .0001), and eGFR (P < .0001) were statistically significant in the first week post‐transplant. In comparison with serum NGAL (P < .0001), creatinine (P < .0001), β2‐microglobulin (P = .001), and eGFR (P = .001), the change ratios of urinary NGAL changed the most between day 1 and day 2 after renal transplantation, while the changing degree of urinary NGAL showed no significant difference compared with these indicators between day 1 and day 7 after kidney transplantation. Conclusion Urinary NGAL is a sensitive marker for indicating renal function. Urinary NGAL combined with other markers can be more helpful for evaluating renal function in the first week following kidney transplantation.

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Section: Discussionsupporting

confidence: 89%

Urinary neutrophil gelatinase‐associated lipocalin rapidly decreases in the first week after kidney transplantation

Wang

et al. 2020

Clinical Laboratory Analysis

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“…Upon mild kidney injury, serum CYS-C begins to increase 24–48 h before serum Cr increases, and serum CYS-C gradually increases under disease progression [31]. Previous studies showed that serum CYS-C was an independent and significant indicator for predicting AKI secondary to decompensated cirrhosis [32] and after radical gastrectomy [33]. Previous studies have shown that age, gender, and race can affect the level of serum CYS-C in adolescents [34].…”

Section: Discussionmentioning

confidence: 99%

Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis

et al. 2018

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Aims The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n = 237) diagnosed with acute pancreatitis without any renal injury. The following information including age, gender, serum creatinine, serum urea nitrogen, serum uric acid, serum cystatin C, fasting serum glucose, serum amylase, serum lipase, serum choline esterase, total protein, albumin, globulin, total bilirubin, direct bilirubin, total bile acids, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, gamma glutamyl transpeptidase, and alkaline phosphatase were collected from each patient when they were diagnosed with acute pancreatitis. Student t-test was conducted to figure out the difference between patients with and without AKI. Univariate and multivariate logistic regression analyses were used for investigating the predictors for AKI in patients with acute pancreatitis. Results 18 (7.6%) patients in total had developed AKI among the study group. Compared with patients without AKI (1.01 ± 0.26 mg/L), the level of baseline serum cystatin C (CYS-C) was significantly higher in patients with AKI (3.64 ± 2.17 mg/L, P < 0.001). Baseline serum CYS-C (OR = 203.594, P < 0.001) was the independent and significant predictor for AKI in patients with acute pancreatitis. AKI in patients with acute pancreatitis could be identified with a sensitivity of 88.9% at specificity of 100% (AUC = 0.948, 95% CI 0.879–1.000) by baseline serum CYS-C (cut-off value = 1.865 mg/L). Conclusions Baseline serum CYS-C shall be adopted to predict the potential risk of AKI in patients with acute pancreatitis.

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“…NGAL, also known as lipocalin-2 or ferritin, is a member of the lipocalin superfamily and is produced in response to stress. NGAL may cause acute kidney injury and is one of the most effective biomarkers of acute kidney injury [ 46 ] ( Fig. 4 ).…”

Section: Four Major Hypotheses and Related Biomarkersmentioning

confidence: 99%

Advances in biomarker development and potential application for preeclampsia based on pathogenesis

Liu

Guo

Gong

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

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Preeclampsia (PE) is a pregnancy-specific complication that seriously threatens the health and safety of mothers and infants. The etiology of PE has not been fully elucidated, and no effective treatments are currently available. A pregnant woman with PE often has to make a tough choice on either endangering her own health to give a birth or being forced to terminate her pregnancy. It is recommended by the International Federation of Gynecology and Obstetrics that the combination of maternal high-risk factors and biomarkers could form a good strategy for predicting the risk of PE. Such a combination may also enable more effective monitoring and early clinical intervention in high-risk populations to reduce the risk of PE. Therefore, biomarkers validated by extensive clinical research may be formally applied for clinical PE risk prediction. In this review, we summarized data from clinical research on potential biomarkers and classified them according to the current four major hypotheses, namely placental or trophoblast ischemia and hypoxia, vascular endothelial injury, oxidative stress, and immune dysregulation. Additionally, we also discussed the underlying mechanisms by which these potential biomarkers may be involved in the pathogenesis of PE. Finally, we propose that multiple biomarkers reflecting different aspects of the disease pathogenesis should be used in combination to detect the high-risk PE population in support of clinically targeted intervention and prevention of PE. It is expected that tests made of more sensitive and reliable PE biomarkers based on the aforementioned major hypotheses could potentially improve the accuracy of PE prediction in the future.

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Value of urinary KIM-1 and NGAL combined with serum Cys C for predicting acute kidney injury secondary to decompensated cirrhosis

Cited by 73 publications

References 19 publications

Urinary neutrophil gelatinase‐associated lipocalin rapidly decreases in the first week after kidney transplantation

Urinary neutrophil gelatinase‐associated lipocalin rapidly decreases in the first week after kidney transplantation

Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis

Advances in biomarker development and potential application for preeclampsia based on pathogenesis

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