Value of VLCD supplementation with medium chain triglycerides

Krotkiewski, M

doi:10.1038/sj.ijo.0801682

Cited by 86 publications

(70 citation statements)

References 26 publications

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“…Previously, Krotkiewski conducted a very-low-calorie diet (578.5 kcal/day) with LCT or MCT (8.0 and 9.9 g) in 66 obese women with BMI ≥ 30 kg/m 2 . He concluded that replacement of LCT by MCT in the very-low-calorie diet suppressed body fat accumulation (23). However, the effect on visceral fat was not investigated in his study.…”

Section: Discussionmentioning

confidence: 94%

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Nosaka

Maki

Suzuki

et al. 2003

JAT

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We found previously that the ingestion of margarine containing medium-chain triacylglycerols (MCT) resulted in a significant increase in postprandial thermogenesis when compared with long-chain triacylglycerols (LCT). Diets that included margarine containing MCT and LCT were compared for 12 weeks in 73 subjects to investigate the effects on body weight, body fat, areas of subcutaneous and visceral fat, serum total cholesterols, triglycerides, lipoproteins, plasma glucose, serum insulin, total ketone bodies, and the activities of aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltranspeptidase. We conducted a double-blind, controlled study and used blended rapeseed oil and soybean oil (LCT) as a comparison. Two groups ingested 2,100-2,400 kcal/day of energy, 65-73 g/day of total fat, and 14 g/day of test margarine (5 g/day of MCT or LCT). The subjects on the MCT diet demonstrated significant decreases in body fat weight (-3.8 ± 2.4 kg vs -2.4 ± 1.7 kg; MCT vs LCT, mean ± SD), subcutaneous fat (-38.2 ± 29.9 cm 2 vs -22.6 ± 19.3 cm 2 ), and visceral fat (-12.2 ± 11.2 cm 2 vs -1.6 ± 12.8 cm 2 ) after 12 weeks. There were no clinical differences in measured blood parameters. We suggest that the postprandial increase in thermogenesis and control of postprandial triglyceride levels may explain these results. J Atheroscler Thromb, 2003; 10: 290-298.

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Section: Discussionmentioning

confidence: 94%

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Nosaka

Maki

Suzuki

et al. 2003

JAT

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“…After 4 weeks of the control diet, also with 40 en% fat (of which 75% was olive oil), these significant differences in the named parameters compared with baseline were no longer present [42] (LOE Ib). However, the advantages related to energy balance were already no longer able to be verified by adaptation mechanisms in the 2nd-4th week of application [43,44] (LOE Ib). As MCT lead to intolerances in larger quantities (>60 g/day), a maximum of 80-120 kcal can be saved per day through the use of MCT.…”

Section: Quantity and Quality Of Dietary Fat And Fatty Acid Intake mentioning

confidence: 99%

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Wolfram

Bechthold²,

Boeing

et al. 2015

Ann Nutr Metab

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As nutrition-related chronic diseases have become more and more frequent, the importance of dietary prevention has also increased. Dietary fat plays a major role in human nutrition, and modification of fat and/or fatty acid intake could have a preventive potential. The aim of the guideline of the German Nutrition Society (DGE) was to systematically evaluate the evidence for the prevention of the widespread diseases obesity, type 2 diabetes mellitus, dyslipoproteinaemia, hypertension, metabolic syndrome, coronary heart disease (CHD), stroke, and cancer through the intake of fat or fatty acids. The main results can be summarized as follows: it was concluded with convincing evidence that a reduced intake of total and saturated fat as well as a larger intake of polyunsaturated fatty acids (PUFA) at the expense of saturated fatty acids (SFA) reduces the concentration of total and low-density lipoprotein cholesterol in plasma. Furthermore, there is convincing evidence that a high intake of trans fatty acids increases risk of dyslipoproteinaemia and that a high intake of long-chain polyunsaturated n-3 fatty acids reduces the triglyceride concentration in plasma. A high fat intake increases the risk of obesity with probable evidence when total energy intake is not controlled for (ad libitum diet). When energy intake is controlled for, there is probable evidence for no association between fat intake and risk of obesity. A larger intake of PUFA at the expense of SFA reduces risk of CHD with probable evidence. Furthermore, there is probable evidence that a high intake of long-chain polyunsaturated n-3 fatty acids reduces risk of hypertension and CHD. With probable evidence, a high trans fatty acid intake increases risk of CHD. The practical consequences for current dietary recommendations are described at the end of this article.

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“…In a different context to that of a high-fat diet and an animal model, Krotkiewski [20], investigating the effect of supplementation with MCT, detected a reduction in body weight in the first 2 weeks of treatment of adult women in comparison with the control group, a difference that disappeared in the final phase of the study.…”

Section: Discussionmentioning

confidence: 98%

High‐fat diet based on trienantin has no adverse metabolic effects in rats

Lucena

Oliveira

Ataíde

et al. 2010

Euro J Lipid Sci & Tech

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The present study was designed to evaluate the metabolic effects of a high-fat diet based on trienantin, an uncommon medium-odd-chain triacylglycerol. Male Wistar rats (33.37 6 5.69 g) (n = 3610) were maintained for 6 weeks on a control diet (7 g soya oil/100 g) or a high-fat diet based on trienantin (40 g margarine, 4 g soya oil and 25.79 g trienantin/100 g), or a high-fat diet based on soya oil (40 g margarine and 29.79 g soya oil/100 g). The serum lipid profile, hepatic function and injury markers, and renal function and injury markers were determined. Samples of liver, stomach, kidney and small intestine were collected for histological analysis. The animals fed the high-fat diet based on trienantin exhibited a lower body weight gain in relation to the control group, between the second and fifth week of the experiment. There were no differences amongst the biochemical markers of the three groups (p !0.05). Lipid infiltration of the hepatocytes was detected in a similar manner in all groups (p !0.05). These data demonstrate that the high-fat diet based on trienantin did not promote adverse metabolic effects under the conditions of this study. This could serve as a reference parameter in the evaluation of the safety of its therapeutic application.

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Value of VLCD supplementation with medium chain triglycerides

Cited by 86 publications

References 26 publications

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

High‐fat diet based on trienantin has no adverse metabolic effects in rats

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