Value of α-fetoprotein in association with clinicopathological features of hepatocellular carcinoma

Liu, Chang; Xiao, Guangqin; Yan, Lü-Nan; Li, Bo; Jiang, Li; Wen, Tianfu; Wang, Wentao; Xu, Mingqing; Yang, Jingchun

doi:10.3748/wjg.v19.i11.1811

Cited by 112 publications

(96 citation statements)

References 39 publications

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“…Furthermore, AFP elevation in HCC was associated with macrovascular invasion in some studies [38,39] . In the present study, serum AFP levels were correlated with tumor size, which is consistent with the results of previous studies [5,35,36] . There was also a relationship between AFP levels and the tumor number, similar to the other studies [37,40] .…”

Section: Discussionsupporting

confidence: 82%

“…The relationship between serum AFP levels and tumor characteristics, such as tumor size, tumor number or macrovascular invasion, has been evaluated in many studies [31][32][33][34] . Liu et al [5] showed a relationship between AFP levels and tumor size, however, AFP concentrations…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of HCC without pathological confirmation is achieved by analyzing serum AFP levels combined with imaging techniques, including ultrasonography, magnetic resonance imaging and computerized tomography [5] . The relationship between serum AFP levels and tumor characteristics, such as tumor size, tumor number or macrovascular invasion, has been evaluated in many studies [31][32][33][34] .…”

Section: Discussionmentioning

confidence: 99%

“…AFP is the most commonly used serological marker worldwide to diagnose hepatocellular carcinoma [4] . HCC differentiation, size and macrovascular invasion are strongly associated with AFP; poor differentiation and HCC size ≥ 10 cm are independent predictors of elevated AFP [5] . Collagen is the main component of connective tissue.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

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AIM:To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma (HCC). METHODS:Sixty-eight patients with HCC (mean age of 69.1 ± 10.1), 31 cirrhosis patients (mean age of 59.3 ± 6.3) and 33 healthy volunteers (mean age of 51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein (AFP) values with HCC clinicopathological features, such as tumor size, number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion (diameters; ≤ 3 cm, 3-5 cm Prospective Study ORIGINAL ARTICLEand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer (BCLC) criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at -80 ℃ until use. Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay. RESULTS:In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number, presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls (P < 0.001). Prolidase levels were significantly associated with tumor size and number (P < 0.001, P = 0.002, respectively). Prolidase levels also differed in patients in terms of BCLC staging classification (P < 0.001). Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately (P = 0.032, P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation (r = 0.616; P < 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification, whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels. CONCLUSION:Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. Core tip: Prolidase cleaves dipeptide bonds containing proline, playing a vital role in collagen turnover, matrix remodeling and cell growth. Neoplastic transformation results in deregulation of tissue collagen metabolism, in which metastatic tumor cells produce enhanced amounts of proteases to penetrate basement membranes and the extracellular matrix. Therefore, tumor progression might depend on the breakdown of collagen and other extracellular matrix proteins. The role of prolidase in neoplastic tissues is unknown. Herein, serum prolidase levels in hepatocellular carcinoma (HCC) patients were significantly associated with tumor size and number, Barcelona-clinic liver can...

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

View full text Add to dashboard Cite

show abstract

“…Although AFP is not elevated in all patients with HCC, a high serum AFP has been associated with advanced tumor stage, including greater tumor size, bilobar involvement, massive or diffuse-type tumor, poorer differentiation and PVT (18,19). The serum AFP level was found to be significantly higher in HCC patients with BCLC stage D compared to stage A and B (18) and was also associated with prognosis. In addition, the AFP level has been considered as an important predictor of postoperative HCC recurrence and metastasis (20,21).…”

Section: Discussionmentioning

confidence: 81%

GALNT14 genotype, α-fetoprotein and therapeutic side effects predict post-chemotherapy survival in patients with advanced hepatocellular carcinoma

Lin

Hsu

Chen

et al. 2014

Molecular and Clinical Oncology

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Abstract. In addition to targeted agents, chemotherapy is currently considered to be a treatment option for patients with advanced hepatocellular carcinoma (HCC); however, it is associated with severe side effects that may limit its clinical use. UDP-N-acetyl-α-D-galactosamine:polypep tide N-acetyl-galactosaminyltransferase 14 (GALNT14) genotype was previously identified as a prognostic marker for HCC patients receiving 5-fluorouracil, mitoxantrone and cisplatin (FMP) combination chemotherapy. The present study aimed to assess clinical parameters and on-treatment side effects as effective predictors for favorable prognosis. A total of 118 patients with HCC receiving split-dose FMP were retrospectively enrolled. The clinical parameters, side effects and GALNT14 genotype were analyzed. The independent predictors for time-to-progression (TTP) and overall survival (OS) were assessed using Cox proportional hazards models. Following categorization, the Kaplan-Meier method was used to compare survival outcomes. Pretreatment α-fetoprotein (AFP) ≤2,800 ng/ml (median level), GALNT14 'TT' genotype, on-treatment leukopenia and absence of vomiting were identified as independent predictors of a favorable TTP (P= 0.001, 0.035, 0.008 and 0.009, respectively) and OS (P= 0.028, 0.006, 0.027 and 0.013, respectively). A total of 59 patients with AFP ≤2,800 ng̸ml exhibited longer median TTP and OS (3.11 vs. 1.75 months, P<0.001; and 8.14 vs. 3.79 months, P<0.001, respectively). A total of 30 patients with the GALNT14 'TT' genotype exhibited longer median TTP and OS (3.11 vs. 2.11 months, P= 0.014; and 5.75 vs. 3.93 months, P=0.001, respectively). Finally, 9 patients (9/118; 7.6%) with all four favorable factors exhibited the longest median TTP and OS (10.64 vs. 2.07 months, P= 0.002; and 25.50 vs. 4.50 months, P<0.001, respectively). In conclusion, the AFP level and the GALNT genotype may be considered as pre-therapeutic predictors of a favorable response. When combined with on-treatment leukopenia and absence of vomiting, a subgroup of patients with excellent outcome may be identified.

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The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

et al. 2017

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Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real‐time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1‐fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan–Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence‐free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the α‐fetoprotein (AFP) level. The patient subgroup with higher AFP levels (≥20 ng/mL) exhibited significant differences in 5‐year overall (18.5% vs. 67.9%) and recurrence‐free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (<20 ng/mL). Multivariate analysis defined UQCRH as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH overexpression is correlated with poor outcomes of HCC patients. Furthermore, in patients grouped as high risk based on elevated AFP, lack of UQCRH overexpression could be a useful indicator for clinical treatment.

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Value of α-fetoprotein in association with clinicopathological features of hepatocellular carcinoma

Abstract: HCC differentiation, size and vascular invasion have strong relationships with AFP, poor differentiation and HCC size ≥ 10 cm are independent predictors of elevated AFP. BCLC shows better relationship with AFP.

Cited by 112 publications

References 39 publications

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

GALNT14 genotype, α-fetoprotein and therapeutic side effects predict post-chemotherapy survival in patients with advanced hepatocellular carcinoma

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

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