Value Research of NLR, PLR, and RDW in Prognostic Assessment of Patients with Colorectal Cancer

Chen, Wanchen; Shen, Xipeng; Xu, Baohong

doi:10.1155/2022/7971415

Cited by 33 publications

(26 citation statements)

References 23 publications

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“…the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), have been investigated in several disease states, e.g. solid tumours, systemic lupus erythematosus, coronary artery disease, retinal artery occlusion, chronic kidney disease and stable COPD [11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future

Zinellu

Zinellu²,

Mangoni³

et al. 2022

Eur Respir Rev

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Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause of hospitalisation and death in COPD patients. In addition to the identification of better strategies to prevent AECOPD, there is an intense focus on discovering novel markers of disease severity that enhance risk stratification on hospital admission for the targeted institution of aggressiveversussupportive treatments. In the quest for such biomarkers, an increasing body of evidence suggests that specific indexes derived from routine complete blood counts,i.e.the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), can significantly predict adverse outcomes in AECOPD. This narrative review discusses the current evidence regarding the association between the NLR and the PLR on admission and several clinical end-points (need for invasive ventilation, noninvasive mechanical ventilation failure, admission to an intensive care unit, pulmonary hypertension, length of hospitalisation, and mortality) in AECOPD. Future research directions and potential clinical applications of these haematological indexes in this patient group are also discussed.

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Section: Introductionmentioning

confidence: 99%

Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future

Zinellu

Zinellu²,

Mangoni³

et al. 2022

Eur Respir Rev

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“…A total of 76 studies were found in the databases, including 25 studies in the PubMed, 50 studies in the Embase and 1 study in the Cochrane Library. Finally, seven studies ( 23 – 26 , 31 – 33 ) were included for final analysis. The flow chart of the study selection was shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies had reported the relationship between RDW and the prognosis of CRC ( 23 – 26 , 31 – 33 ). Zhang X et al ( 23 ) reported that elevated RDW could be an independent factor for non-metastatic rectal cancer; Cheng KC et al ( 37 ) analyzed 5,315 CRC patients and did propensity score matching analysis, they found that RDW was a predictor of OS, DFS and CSS.…”

Section: Discussionmentioning

confidence: 99%

“…There were many factors which could affect the prognosis of CRC, including tumor stage, tumor size, age, body mass index (BMI), type 2 diabetes mellitus and so on ( 39 – 44 ). Prognostic indicators related to blood examination included lymphocyte count ratio (NLR), platelet count and lymphocyte count ratio (PLR), etc ( 31 , 45 , 46 ). The main reason that NLR and PLR could affect the prognosis was that they were important markers of systemic inflammation ( 23 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

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Is red blood cell distribution width a prognostic factor for colorectal cancer? A meta-analysis

2022

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BackgroundRDW might be an easy and cost-effective pre-operative prognostic factor for cancer patients. The aim of the current study was to analyze whether red blood cell distribution width (RDW) was a prognostic factor for colorectal cancer (CRC) patients who underwent radical surgery.MethodsWe conducted the searching strategy in three databases including the PubMed, Embase and Cochrane Library from the inception to May 07, 2022, to find eligible studies. In this meta-analysis, we focused on the prognosis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for overall survival (OS), disease-free survival (DFS) and cancer-specific survival (CSS).ResultsA total of seven studies involving 7,541 patients were included in this meta-analysis. After pooling up the HRs, red blood cell distribution width-coefficient of variation (RDW-CV) was not an independent prognostic factor of OS (HR = 1.48, I2 = 90%, 95% CI = 0.93 to 2.36, P = 0.10), however, red blood cell distribution width-standard deviation (RDW-SD) was an independent prognostic factor of OS (HR = 1.99, I2 = 0%, 95% CI = 1.59 to 2.49, P < 0.01). As for DFS, we found that RDW-CV (HR = 1.51, I2 = 83%, 95% CI = 0.94 to 2.43, P = 0.09 < 0.10) and RDW-SD (HR = 1.77, I2 = 56%, 95% CI = 0.91 to 3.43, P = 0.09 < 0.10) were both the independent prognostic factors. In terms of CSS, we found that RDW-CV was not an independent prognostic factor (HR = 1.23, I2 = 95%, 95% CI = 0.72 to 2.10, P = 0.46).ConclusionRDW-SD was an independent prognostic factor of OS and DFS, and RDW-CV was an independent prognostic factor of DFS.

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“…In the previous studies, many risk factors and prognostic variables were identi ed, including tumor markers, histological type, tumor location, platelet count [4], and tumor-node-metastasis(TNM) staging system. These factors are related to the prognosis of colorectal tumors [5].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic nomogram for distant metastasis in newly diagnosed colorectal cancer based on clinical features

Cao

Ding

et al. 2022

Preprint

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Background Colorectal cancer is one of the most common primary malignancies and the third most common cause of cancer death in both men and women in the United States. Among people diagnosed with initial colorectal cancer, 22% had metastatic colorectal cancer, while the 5-year survival rate was less than 20%. Methods We retrospectively reviewed the data of patients who were diagnosed as Colorectal cancer in Zhong nan Hospital of Wuhan University and People's Hospital of Gansu Province between January 2016 and December 2021.Risk predictors for distant metastasis from colorectal patients were determined by the univariate and multivariate logistic regression analysis. Nomograms were developed to predict the probabilities of distant metastatic sites of Colorectal cancer patients and evaluated by calibration curves, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). Results A total of 327 cases were included in this study, 224 colorectal cancer patients from Zhong nan Hospital of Wuhan University were incorporated into the training set, and 103 colorectal cancer patients from Gansu Provincial People's Hospital were incorporated into the testing set. By univariate logistic regression analysis, platelet level (PLT) (p = 0.009), CEA level (p = 0.032), histological grade (p < 0.001), colorectal cancer tumor markers (p < 0.001) and N stage (p < 0.001), tumor site (p = 0.013) were associated with distant metastasis in colorectal cancer patients. The C-indexes for the prediction of the nomogram were 0.898(95% confidence interval (CI), 0.851–0.945). Conclusions The nomogram showed excellent accuracy in predicting distant metastatic sites and clinical utility may facilitate clinical decision-making.

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Value Research of NLR, PLR, and RDW in Prognostic Assessment of Patients with Colorectal Cancer

Cited by 33 publications

References 23 publications

Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future

Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future

Is red blood cell distribution width a prognostic factor for colorectal cancer? A meta-analysis

Diagnostic nomogram for distant metastasis in newly diagnosed colorectal cancer based on clinical features

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