Aortic valve replacement (AVR) is the most frequently performed procedure in valve surgery.The controversy about the optimal choice of the prosthetic valve is as old as the technique itself. Currently there is no perfect valve substitute available. The main challenge is to choose between mechanical and biological prosthetic valves. Biological valves include pericardial (bovine, porcine or equine) and native porcine bioprostheses designed in stented or stentless versions. Homografts and pulmonary autografts are reserved for special indications and will not be discussed in detail in this review. We will focus on the decision making between artificial biological and mechanical prostheses, respectively.The first part of this article reviews guideline recommendations concerning the choice of aortic prostheses in different clinical situations while the second part is focused on novel strategies in the treatment of patients with aortic valve pathology.Keywords: aortic valve replacement, biological valve prosthesis, mechanical valve prosthesis, oral anticoagulation, novel oral anticoagulants.
Current EvidenceThe current guidelines of the European Society of Cardiology from 2012 [1] and of the American Heart Association from 2014 [2] uniformly recommend mechanical aortic valve replacement (AVR) in patients under 60 years of age and biologic AVR in patients over 70 years of age (Fig. 1). In patients between 60 and 70 years of age, recommendations are conflicting. The ESC-Guidelines recommend biologic prosthesis from the age of 65 years onwards, whereas the newer AHA/ACC guidelines only recommend biological valves starting with 70 years of age. Looking at the development of the guidelines over the last 20 years there is a shift away from a clear-cut age limit towards the patients wish and life-style considerations.Currently there is a trend towards more biological AVR, also in patients under 65 years of age, which is contrary to the progress of life expectancy of patients at this age.Justification for this approach is the option for a valve-in-valve procedure in the case of structural valve deterioration (SVD) which might become a routine bail out strategy. In addition, the last generation of pericardial tissue valves may have excellent long-term durability over 20 years. However, current studies also demonstrate a significant age-