Valvular Heart Disease in Critical Care

Turi, Zoltan G.

doi:10.1016/b978-032304841-5.50035-2

Cited by 1 publication

(1 citation statement)

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“…Aortic valve sclerosis (AVSc) is defined as the thickening and calcification of the aortic valve leaflets 1 in the absence of obstruction of ventricular outflow, 2 with a gradient of <20–25 mmHg. 3 AVSc is characterized by increased stiffness, thickness, and calcification of the aortic leaflets without fusion of commissures. 4 , 5 AVSc is the most common valve disorder in developed countries 6 and is prevalent in Western countries.…”

Section: Introductionmentioning

confidence: 99%

Trace elements in patients with aortic valve sclerosis

Al-Taesh

Çelekli

Sucu

et al. 2021

Therapeutic Advances in Cardiovascular Disease

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Background: Aortic valve sclerosis (AVSc) is defined as the thickening and calcification of aortic valve cusps, in the absence of obstruction of ventricular outflow. AVSc is linked with a clear imbalance in some trace elements. Aims: The objective of this study was to investigate the relationship between AVSc and serum levels of iron (Fe), zinc (Zn), selenium (Se), and copper (Cu). Additionally, this research aimed to explore the clinical significance of human serum zinc, selenium, copper, and iron concentrations as a potential new biomarker for AVSc patients and to clarify the pathophysiological role in individuals at risk of developing AVSc. Patients and methods: The study included 40 subjects with AVSc (25% male and 75% female) who were compared with a healthy control group with the same gender ratio. AVSc was based on comprehensive echocardiographic assessments. Blood samples were taken and Zn and Cu concentrations were determined through the use of atomic absorption spectroscopy. Se was measured using an inductively coupled plasma mass spectrometry device and Fe was measured using a Beckman Coulter instrument. Results: There was a significant difference in the prevalence of diabetes, blood pressure levels, and body mass index between the patients and the healthy subjects ( p < 0.05). The differences between the serum Fe, Se, and Cu levels of the AVSc patients and the healthy subjects ( p > 0.05) were recorded. The serum Zn of AVSc patients when compared was significantly lower compared with that of the control group ( p < 0.01). Conclusion: Patients with AVSc had an imbalance in some of the trace elements in their blood. The patient group’s valves had higher serum Cu levels and lower serum Se, Zn, and Fe concentrations compared with the healthy group’s valves. In the valve patients as compared, AVSc had a high prevalence of obesity, hypertension, and diabetes.

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