“…Two main v-SNAREs were shown to mediate distinct exocytic mechanisms: clostridial neurotoxin-sensitive VAMP2 (and the closely related VAMP1 and VAMP3) mediates synaptic vesicle and early endosomal exocytosis, whereas clostridial neurotoxin-insensitive VAMP7 mediates Golgi-derived, late endosomal and lysosomal secretory pathways ( Proux-Gillardeaux et al., 2005a ), which are best defined by the presence of the tetraspanin CD63 ( Chiaruttini et al., 2016 , Coco et al., 1999 ). In the recent years, lysosomal exocytosis has appeared as a very general mechanism that can be found in virtually any cell type ( Ghosh et al., 2016 , Jaiswal et al., 2002 , Li et al., 2008 , Verderio et al., 2012 ). Interestingly enough, VAMP2 and VAMP3 were shown to mediate integrin recycling ( Hasan and Hu, 2010 , Proux-Gillardeaux et al., 2005b , Skalski and Coppolino, 2005 , Tayeb et al., 2005 ), and VAMP7, to play an essential role in cell migration and invasion ( Proux-Gillardeaux et al., 2007 , Steffen et al., 2008 , Williams and Coppolino, 2011 ).…”