Vanadatesulfuric Acid-catalyzed Novel and Eco-benign one-pot Synthesis of Polyhydroquinoline Derivatives under Solvent-free Conditions

Abstract

A novel and green approach for efficient and rapid synthesis of biologically active polyhydroquinoline derivatives via unsymmetric Hantzsch reaction using nanorods Vanadatesulfuric acid (VSA NRs) as a new and recyclable catalyst under solvent-free conditions was reported. The catalyst was characterized by FT-IR, XRD, XRF and TEM analysis. The present method offers several advantages such as simple procedure, short reaction time, high yields, simple workup, reusability of the catalyst and simple purification of the products.