Vanadium—an element of atypical biological significance

Mukherjee, Biswajit; Patra, Balaram; Mahapatra, S. K.; Banerjee, Pratik; Tiwari, Amit K.; Chatterjee, Mainak

doi:10.1016/j.toxlet.2004.01.009

Cited by 339 publications

(198 citation statements)

References 63 publications

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“…For example, DMT1 transports VO 2ϩ at significantly lower affinity than it does Fe 2ϩ , and iron is more abundant in the diet than is vanadium, such that DMT1-mediated vanadium absorption is probably extremely low; nevertheless, DMT1 may suffice vanadium absorption because the metal is required in only trace amounts. Deficiency of vanadium results in growth retardation and altered metabolism of glucose and lipids (41). An intestinal anionic transport system may additionally serve in the absorption of vanadate (oxoanions of vanadium) (41).…”

Section: Discussionmentioning

confidence: 99%

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Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

Illing

Shawki

Cunningham

et al. 2012

Journal of Biological Chemistry

227

195

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Background: DMT1 plays essential roles in iron homeostasis, but questions remain about which other metals this transporter serves. Results: DMT1 exhibits substrate selectivity Cd 2ϩ Ͼ Fe 2ϩ Ͼ Co 2ϩ , Mn 2ϩ Ͼ Ͼ Ni 2ϩ , VO 2ϩ , Zn 2ϩ . Conclusion: DMT1 is an iron-preferring transporter that does not transport copper. Significance: These findings will help in predicting the contribution of DMT1 to absorption and cellular uptake of metal ions.

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Section: Discussionmentioning

confidence: 99%

“…Deficiency of vanadium results in growth retardation and altered metabolism of glucose and lipids (41). An intestinal anionic transport system may additionally serve in the absorption of vanadate (oxoanions of vanadium) (41).…”

Section: Discussionmentioning

confidence: 99%

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

Illing

Shawki

Cunningham

et al. 2012

Journal of Biological Chemistry

227

195

View full text Add to dashboard Cite

show abstract

“…Water consumption is one of the routes of entry into the human body, where vanadium is absorbed and transported to several tissues through the blood stream [19] and accumulates in the liver, kidneys, bones, lungs, etc. [20,21].…”

Section: Introductionmentioning

confidence: 99%

Natural Contaminants in Drinking Waters (Arsenic, Boron, Fluorine and Vanadium) in the Southern Pampean Plain, Argentina

Espósito¹,

Paoloni²,

Sequeira³

et al. 2011

JEP

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“…Moreover, vanadium toxicological effects in several cell types have been related with ROS production [16][17][18][19]. Nevertheless, vanadium was recently reviewed as ''an element of atypical biological significance'' [20], due to insulin mimetic properties of vanadium [16,21,22] and to the preventive effects of vanadium against animal carcinogens [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

Gândara

Soares

Martins

et al. 2005

Journal of Inorganic Biochemistry

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The formation of vanadate oligomeric species is often disregarded in studies on vanadate effects in biological systems, particularly in vivo, even though they may interact with high affinity with many proteins. We report the effects in fish hepatic tissue of an acute intravenous exposure (12, 24 h and 7 days) to two vanadium(V) solutions, metavanadate and decavanadate, containing different vanadate oligomers administered at sub-lethal concentration (5 mM; 1 mg/kg). Decavanadate solution promotes a 5-fold increase (0.135 ± 0.053 lg V À1 dry tissues) in the vanadium content of the mitochondrial fraction 7 days after exposition, whereas no effects were observed after metavanadate solution administration. Reduced glutathione (GSH) levels did not change and the overall reactive oxygen species (ROS) production was decreased by 30% 24 h after decavanadate administration, while for metavanadate, GSH levels increased 35%, the overall ROS production was depressed by 40% and mitochondrial superoxide anion production decreased 45%. Decavanadate intoxication did not induce changes in the rate of lipid peroxidation till 12 h, but later increased 80%, which is similar to the increase observed for metavanadate after 24 h. Decameric vanadate administration clearly induces different effects than the other vanadate oligomeric species, pointing out the importance of taking into account the different vanadate oligomers in the evaluation of vanadium(V) effects in biological systems.

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Vanadium—an element of atypical biological significance

Cited by 339 publications

References 63 publications

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

Natural Contaminants in Drinking Waters (Arsenic, Boron, Fluorine and Vanadium) in the Southern Pampean Plain, Argentina

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

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