Vanadium and zinc complexes of 5-cyanopicolinate and pyrazine derivatives: synthesis, structural elucidation and in vitro insulino-mimetic activity study

Abstract

Inhibition of free fatty acid release from rat adipocytes was observed for vanadium(iv), vanadium(v) and zinc(ii) complexes.

Synthesis, characterization and immobilization of a novel mononuclear vanadium (V) complex on modified magnetic nanoparticles as catalyst for epoxidation of allyl alcohols

“…Due to the presence of vanadium in biological systems, in the active centre of some enzymes (haloperoxidases and nitrogenases) and its insulin enhancing action and anticancer activity, it has driven a considerable amount of research. Synthesis of vanadium complexes containing polypyridyl ligands have been carried out and used as anti‐protozoa, anti‐tumor, antiparasitic, DNA cleavage, insulin mimetic activity, oral insulin substitutes for the treatment of diabetes and for the treatment of obesity and hypertension . Moreover, due to the relevance to biochemical field and its medicinal applications and as a probe in protein studies, vanadium compounds are used in several industrial fields such as homogeneous and heterogeneous catalysts and battery fabrication .…”

“…Synthesis of vanadium complexes containing polypyridyl ligands have been carried out and used as anti-protozoa, [3,4] anti-tumor, [4,5] antiparasitic, [5] DNA cleavage, insulin mimetic activity, oral insulin substitutes for the treatment of diabetes and for the treatment of obesity and hypertension. [6] Moreover, due to the relevance to biochemical field and its medicinal applications [7] and as a probe in protein studies, [8] vanadium compounds are used in several industrial fields such as homogeneous [9] and heterogeneous [10] catalysts and battery fabrication. [11] Vanadium complexes including simple vanadium (III, IV, and V) compounds such as VCl 3 , [12] VO(acac) 2 , [13] NaVO 3 [14] as well as vanadium complexes with polydentate ligands such as salophene, [15] 3-hydroxy-4-pyrone and 3-hydroxy-4-pyridinone, [16] hydrazones, [17] Schiff bases, [18] tris(pyrazolyl) ethanol, [19] pyrazine-2-carboxylate, [20] bishydroxamic acid (BHA) [21] and bis (aryl)-2pyridylmethanol [22] have been used for the homogeneous catalytic oxidation with H 2 O 2 , t-BuOOH, cumene hydroperoxide (CHP) and O 2 .…”

Bis(picolinato) complexes of vanadium and zinc as potential antidiabetic agents: synthesis, structural elucidation and in vitro insulin-mimetic activity study

“…The N-donor ligands were selected in order to make a structural comparison with previously published zinc complexes with the 5-cyanopicolinato (picCN) organic carrier where a cis-octahedral arrangement was observed in py and 4-aminopyridine (4apy) complexes and also a square-pyramidal geometry was observed in the 4apy complex in contrast to the [Zn(picCN) 2 (H 2 O) 2 ] complex possessing a trans arrangement of the ligands in the coordination sphere. 23 The reaction of 5 with py in toluene/methanol yielded crystals 6Ápy, however, when these crystals were dried in air, the pyridine was lost and the complex decomposed transforming into the compound 5 as was observed also in the analogous system with the picCN ligand. 23 The reaction of 9 with DMAP yielded complex 11 even though the ratio 1 : 2 was used.…”

“…23 The reaction of 5 with py in toluene/methanol yielded crystals 6Ápy, however, when these crystals were dried in air, the pyridine was lost and the complex decomposed transforming into the compound 5 as was observed also in the analogous system with the picCN ligand. 23 The reaction of 9 with DMAP yielded complex 11 even though the ratio 1 : 2 was used. A small amount of crystals of 10 with methanol molecules bonded to the metal center were obtained during the unsuccessful synthesis of 11 in methanol.…”

Crystal Chemistry of Zinc Quinaldinate Complexes with Pyridine-Based Ligands

“…Since then, over 1000 zinc metalloenzymes, covering all classes of enzymes, have been discovered [2][3][4][5][6]. The prevalent use of zinc in biological systems is due to its unique properties [3,5,[7][8][9][10][11][12][13][14]. Zinc(II) ion is characterized by a filled d subshell.…”