Vanadium, cobalt, zinc, and rubidium are associated with markers of inflammation and oxidative stress in a Greek population with obesity

Amerikanou, Charalampia; Kleftaki, Stamatia-Angeliki; Karavoltsos, Sotirios; Tagkouli, Dimitra; Sakellari, Aikaterini; Valsamidou, Evdokia; Gioxari, Aristea; Kalogeropoulos, Nick; Kaliora, Andriana C.

doi:10.3389/fendo.2023.1265310

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Rubidium is an alkali metal, and its compounds have various chemical and electronic applications. It is not a known nutrient, but its ions are known to have similar properties and the same charge as potassium ions [126].…”

Section: Rubidium (Rb)mentioning

confidence: 99%

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Tyczyńska,

Gędek,

Brachet

et al. 2024

JCM

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Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims to present the role that trace elements play in the central nervous system. Moreover, we reviewed the mechanisms involved in their neurotoxicity. Low zinc concentrations, as well as high levels of copper, manganese, and iron, activate the signalling pathways of the inflammatory, oxidative and nitrosative stress response. Neurodegeneration occurs due to the association between metals and proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In Alzheimer’s disease, low Zn levels suppress the neurotoxicity induced by β-amyloid through the selective precipitation of aggregation intermediates. High concentrations of copper, iron and manganese cause the aggregation of intracellular α-synuclein, which results in synaptic dysfunction and axonal transport disruption. Parkinson’s disease is caused by the accumulation of Fe in the midbrain dopaminergic nucleus, and the pathogenesis of multiple sclerosis derives from Zn deficiency, leading to an imbalance between T cell functions. Aluminium disturbs the homeostasis of other metals through a rise in the production of oxygen reactive forms, which then leads to cellular death. Selenium, in association with iron, plays a distinct role in the process of ferroptosis. Outlining the influence that metals have on oxidoreduction processes is crucial to recognising the pathophysiology of neurodegenerative diseases and may provide possible new methods for both their avoidance and therapy.

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Section: Rubidium (Rb)mentioning

confidence: 99%

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Tyczyńska,

Gędek,

Brachet

et al. 2024

JCM

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“…The concentration of Co rises with an increase in municipal solid waste (28). Cd, Co, and Pb can induce an inflammatory response in the body through oxidative stress, disrupting the normal functioning of the immune system (29)(30)(31)(32). The experimental result has demonstrated that rats exposed to Pb develop neuroinflammation of microglia in their brains, leading to adverse neurodevelopmental outcomes (33).…”

Section: Introductionmentioning

confidence: 99%

The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female

Nie,

Hu,

Xian

et al. 2024

Front. Public Health

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BackgroundStudies on the association between mixed exposure to common pollutants such as cadmium (Cd), cobalt (Co), lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) with Systemic Immune Inflammatory Index (SII), a novel hemocyte-based inflammatory marker, have not been reported. This study explored the relationship between co-exposure to Cd, Co, Pb, PAHs, and SII.MethodsIn this study, we used data from the National Health and Nutrition Examination Survey and enrolled adults with complete information on Cd, Co, Pb, PAHs, and SII. The linear regression was used to analyze the association of single pollutants with SII. Furthermore, a Bayesian Kernel Machine Regression analysis and a generalized weighted quantile sum regression analysis were used to analyze the association between mixed exposure to Cd, Co, Pb, and six PAHs and SII. We also separated males and females and analyzed the different effects of pollutants on SII, respectively.Results5,176 participants were included in the study. After adjusting for age, gender, race, education, smoking, drinking, physical activity, and sedentary, Cd, Co, 1-OHN, 2-OHN and 2-OHF were positive with SII in the total population. Compared with the 50th percentile, the joint effect of pollutants on SII was positive. In the total population, males, and females, the top contaminant with the highest effect weights on SII were Co, Cd, and 1-OHN, respectively. The result of interaction analysis showed that the low concentrations of Cd had an elevation effect on SII in males.ConclusionThis study found a positive association of mixed exposure to Cd, Co, Pb, and six PAHs with SII, which occurred mainly in females.

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Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity

de Oliveira,

Cruz,

Morais

et al. 2024

Biometals

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Vanadium, cobalt, zinc, and rubidium are associated with markers of inflammation and oxidative stress in a Greek population with obesity

Cited by 5 publications

References 49 publications

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female

Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity

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