Vanadium determination in rat tissues and biological reference materials by neutron activation analysis

Kučera, Jan; Šimková, M; Lener, Jaroslav; Mravcová, A.; Kinova, L.; Penev, I

doi:10.1007/bf02060184

Cited by 10 publications

(2 citation statements)

References 15 publications

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“…[ 56 ] Distribution studies in which rats received a total of approximately 224 and 415 mg vanadium pentoxide/kg in drinking-water over a period of 1 and 2 months indicated that the vanadium content (assessed in 13 specific tissues) was greatest in the kidneys, spleen, tibia and testes. [ 57 ]…”

Section: Resultsmentioning

confidence: 99%

Vanadium pentoxide inhalation

Cooper¹

2007

Indian J Occup Environ Med

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Context:This mini-review describes the toxic effects of vanadium pentoxide inhalation principally in the workplace and associated complications with breathing and respiration. Although there are some material safety data sheets available detailing the handling, hazards and toxicity of vanadium pentoxide, there are only two reviews listed in PubMed detailing its toxicity.Aim:To collate information on the consequences of occupational inhalation exposure of vanadium pentoxide on physiological function and wellbeing.Materials and Methods:The criteria used in the current mini-review for selecting articles were adopted from proposed criteria in The International Classification of Functioning, Disability and Health. Articles were classified from an acute and chronic exposure and toxicity thrust.Results:The lungs are the principal route through which vanadium pentoxide enters the body. It can injure the lungs and bronchial airways possibly involving acute chemical pneumonotis, pulmonary edema and/or acute tracheobronchitis. It may adversely influence cardiac autonomic function. It stimulates the secretion of cytokines and chemokines by hepatocytes and disrupts mitochondria function. It disrupts the permeability of the epithelium and promotes access of inflammatory mediators to the underlying neuronal tissue causing injury and neuronal death. When renal brush border membrane vesicles are exposed to vanadium pentoxide, there is a time-dependent inhibition of citrate uptake and Na+ K+ ATPase in the membrane possibly contributing to nephrotoxicity. Exposure results in necrosis of spermatogonium, spermatocytes and Sertoli cells contributing to male infertility.Conclusion:Vanadium pentoxide certainly has adverse effects on the health and the well-being and measures need to be taken to prevent hazardous exposure of the like.

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Section: Resultsmentioning

confidence: 99%

Vanadium pentoxide inhalation

Cooper¹

2007

Indian J Occup Environ Med

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“…Thus the calculated volume of distribution suggests that vanadium exhibits appreciable tissue binding. This view is supported by animal studies indicating that vanadium accumulates in tissues such as liver, kidneys, bone, and spleen [15, 23–25].…”

Section: Resultsmentioning

confidence: 82%

Pharmacokinetics of vanadium in humans after intravenous administration of a vanadium containing albumin solution

Heinemann

Fichtl

Vogt

2003

Brit J Clinical Pharma

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Aims Vanadium is currently undergoing clinical trials as an oral drug in patients with noninsulin-dependent diabetes mellitus. Furthermore, vanadium occurs in elevated concentrations in the blood of patients receiving intravenous albumin solutions containing large amounts of the metal ion as an impurity. The present study was performed to examine the pharmacokinetics of vanadium in humans following a single intravenous (i.v.) dose of a commercial albumin solution containing a high amount of vanadium. Methods The study was conducted in five healthy volunteer subjects who received intravenously 90 ml of a commercial 20% albumin infusion solution containing 47.6 m g vanadium as an impurity. Vanadium concentrations in serum and urine were determined by electrothermal atomic absorption spectrometry. Results Vanadium serum concentrations after i.v. administration were measured for 31 days. The data could be fitted by a triexponential function corresponding formally to a three-compartment model. There was an initial rapid decrease in serum concentrations with half-lives of 1.2 and 26 h. This was followed by a long-terminal half-life time of 10 days. The terminal phase accounted for about 80% of the total area under the serum concentration-time curve (AUC).

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Radiochemical neutron activation analysis of traces of vanadium in biological samples: A comparison of prior dry ashing with post-irradiation wet ashing

Byrne

Kučera

1991

Fresenius J Anal Chem

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Vanadium determination in rat tissues and biological reference materials by neutron activation analysis

Cited by 10 publications

References 15 publications

Vanadium pentoxide inhalation

Vanadium pentoxide inhalation

Pharmacokinetics of vanadium in humans after intravenous administration of a vanadium containing albumin solution

Radiochemical neutron activation analysis of traces of vanadium in biological samples: A comparison of prior dry ashing with post-irradiation wet ashing

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