Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Abstract

Several reports have revealed the superior biological activity of metal ion-flavonoid complexes when compared with the parent flavonoid. Among the different metal ions explored, vanadium and its compounds are in the forefront because of their anticancer and antidiabetic properties. However, the toxicity of vanadium-based ions and their inorganic derivatives limits their therapeutic applications. Complexation of vanadium with flavonoids not only reduces its adverse effects but also augments its biological activity. This Review discusses the nature of coordination in vanadium–flavonoid complexes, their structure–activity correlations, with special emphasis on their therapeutic activities. Several investigations suggest that the superior biological activity of vanadium complexes arise because of their ability to regulate metabolic pathways distinct from those acted upon by vanadium alone. These studies serve to decipher the underlying molecular mechanism of vanadium–flavonoid complexes that can be explored further for generating a series of novel compounds with improved pharmacological and therapeutic performance.

Systematic Analysis and Prediction of the Target Space of Bioactive Food Compounds: Filling the Chemobiological Gaps

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A Combined Experimental and Theoretical Investigation of Oxidation Catalysis by cis-[VIV(O)(Cl/F)(N4)]+ Species Mimicking the Active Center of Metal-Enzymes

“…In recent years, the coordination chemistry of vanadium has drawn a lot of interest, mainly due to its biological, medicinal and catalytic applications. − Vanadium exhibits a wide variety of oxidation states (−III to + V), with the oxidation states of +III to +V mainly found in molecular systems of biological relevance. Enzymes, such as the vanadium-dependent haloperoxidases found in algae, are able to utilize vanadium’s wide range of oxidation states in order to oxidize halides in nature .…”

A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes

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