Vanadium levels in hair and blood of normal and exposed persons

Kučera, Jan; Byrne, A. R.; Mravcová, A.; Lener, Jaroslav

doi:10.1016/0048-9697(92)90329-q

Cited by 28 publications

(6 citation statements)

References 24 publications

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“…Then, a possible hypothesis, that should be followed by further investigations, is that the excess of iron in the cell inducing oxidative stress via ROS production causes the upregulation of gene coding for the first line defense antioxidants enzymes SOD and GPX, revealed by the increase of their cofactors in the blood of HD patients, We found significant differences in As, Pb, Sb and V levels between patients and controls that deserve additional investigation, even if the concentrations of these nonessential elements were in the range of reference values in blood [18,19].…”

Section: Resultsmentioning

confidence: 67%

Trace elements profile in the blood of Huntington’ disease patients

Squadrone

Brizio

Abete

et al. 2020

Journal of Trace Elements in Medicine and Biology

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Section: Resultsmentioning

confidence: 67%

Trace elements profile in the blood of Huntington’ disease patients

Squadrone

Brizio

Abete

et al. 2020

Journal of Trace Elements in Medicine and Biology

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“…The concentrations of vanadium in the serum and urine of the occupationally vanadium-exposed people participating in these studies were about 9.4-fold and 36-fold higher, respectively, compared to those noted in the nonexposed subjects. Moreover, the serum and urinary vanadium levels in the same exposed workers were about 50-fold and 48-fold higher, compared to the most probable mean baseline serum (~0.15 µg/L) [84] and urinary (0.2-0.4 ng/mL) [21] vanadium concentrations, respectively, reported for humans not exposed to this metal. Another example is the results reported by Li et al [80], who tested the hypothesis that occupational exposure to vanadium in a low-dose long-term exposure condition may lead to an early onset of neurobehavioral changes in vanadium-exposed Chinese workers.…”

Section: Neurological Side Effects/neurobehavioral Changes and Vanadi...mentioning

confidence: 83%

“…The level of vanadium in body fluids and tissues is influenced by several factors, such as age, diet, health status, or occupational exposure [11,21,22]. As for the latter, elevated concentrations of this metal with a well-known industrial value [23] have repeatedly been noted in body fluids of vanadium-exposed workers [24].…”

Section: The Impact Of Certain Factors On the Concentration Of Vanadi...mentioning

confidence: 99%

CNS-Related Effects Caused by Vanadium at Realistic Exposure Levels in Humans: A Comprehensive Overview Supplemented with Selected Animal Studies

Ścibior

Llopis

Dobrakowski

et al. 2023

IJMS

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Neurodegenerative disorders, which are currently incurable diseases of the nervous system, are a constantly growing social concern. They are progressive and lead to gradual degeneration and/or death of nerve cells, resulting in cognitive deterioration or impaired motor functions. New therapies that would ensure better treatment results and contribute to a significant slowdown in the progression of neurodegenerative syndromes are constantly being sought. Vanadium (V), which is an element with a wide range of impacts on the mammalian organism, is at the forefront among the different metals studied for their potential therapeutic use. On the other hand, it is a well-known environmental and occupational pollutant and can exert adverse effects on human health. As a strong pro-oxidant, it can generate oxidative stress involved in neurodegeneration. Although the detrimental effects of vanadium on the CNS are relatively well recognized, the role of this metal in the pathophysiology of various neurological disorders, at realistic exposure levels in humans, is not yet well characterized. Hence, the main goal of this review is to summarize data on the neurological side effects/neurobehavioral alterations in humans, in relation to vanadium exposure, with the focus on the levels of this metal in biological fluids/brain tissues of subjects with some neurodegenerative syndromes. Data collected in the present review indicate that vanadium cannot be excluded as a factor playing a pivotal role in the etiopathogenesis of neurodegenerative illnesses, and point to the need for additional extensive epidemiological studies that will provide more evidence supporting the relationship between vanadium exposure and neurodegeneration in humans. Simultaneously, the reviewed data, clearly showing the environmental impact of vanadium on health, suggest that more attention should be paid to chronic diseases related to vanadium and to the assessment of the dose–response relationship.

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“…Its normal human blood concentrations of about 1 nM, associated with the natural presence of vanadium compounds [ 13 ], may significantly increase in the conditions of considerable anthropogenic vanadium pollution in industrialized and highly urbanized areas [ 14 , 15 , 16 , 17 ]. The pollution results from the combustion of oil and coal which contain large amounts of vanadium [ 18 , 19 ], for example, blood vanadium levels in the population of Taiwan is ca 10 nM [ 20 ] and in factory workers occupationally exposed to vanadium-containing dust may exceed 4 μM [ 13 ]. At this last concentration, vanadium compounds exhibit therapeutic properties in vivo in diabetic rats [ 4 , 21 ] and in vitro in human tumor cells [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases

Korbecki

Baranowska-Bosiacka

Gutowska

et al. 2015

IJMS

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This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.

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Vanadium levels in hair and blood of normal and exposed persons

Cited by 28 publications

References 24 publications

Trace elements profile in the blood of Huntington’ disease patients

Trace elements profile in the blood of Huntington’ disease patients

CNS-Related Effects Caused by Vanadium at Realistic Exposure Levels in Humans: A Comprehensive Overview Supplemented with Selected Animal Studies

Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases

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