Vanadium pentoxide induced oxidative stress and cellular senescence in human lung fibroblasts

He, Xiaojia; Jarrell, Zachery; Liang, Yongliang; Smith, Matthew; Orr, Michael; Marts, Lucian; Go, Young‐Mi; Jones, Dean P.

doi:10.1016/j.redox.2022.102409

Cited by 26 publications

(11 citation statements)

References 89 publications

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“…These adjustable sizes and activity levels allow MVONs to have practical applications in catalysis and biomedicine. [49] The study of manganese-based metal oxide nanozymes had also made progress in recent years, such as MnO, MnO 2 , Mn 2 O 3 , and Mn 3 O 4 . [86,87] Manganese is a necessary mineral for most living organisms, having a strong catalytic effect, and being readily available from various sources, suggesting a degree of biocompatibility.…”

Section: Enzyme-mimetic Reactivities and Ph-dependent Activity Of Red...mentioning

confidence: 99%

“…[141] Notably, changes in H 2 O 2 has been shown to affect the activity of protein kinases and protein phosphatases, mainly via the oxidation of active site cysteines in phosphatases, thus inactivating them. [142] The ability of rNZs to mimic the activity of a broad range of enzymes including catalases (e.g., CeO 2 , [143] Mn 3 O 4 , [144] ZrO 2 [46] ), oxidases (e.g., CeO 2 , [145] CuO 2 , [146] MnFe 2 O 4 , [147] Fe 2 O 3 , [148] ZnO, [149] TiO 2 , [150] V 2 O 5 [49] ), dismutases (e.g., CeO 2 , [70] MnO 2 , [101] Mn 3 O 4 , [151] Fe 3 O 4 [152] ), peroxidases (e.g., CeO 2 , [153] Fe 3 O 4 , [154] V 2 O 5 , [155] MnO 2 , [156] ZnO, [157] CuO, [52] TiO 2 , [150] ZrO 2 [46,47] ), Adenosine Triphosphate-ases (e.g., CeO 2 ), [158,159] and phosphatases (e.g., CeO 2 , [160] FeO x [161] ) has been well established. As such, and due to this surface enzyme-mimetic activity, rNZs have the capacity to participate in a multitude of biologically important reactions.…”

Section: Enzyme-mimetic Activity Of Rnzs and Protein Interactionmentioning

confidence: 99%

“…[ 48 ] Synthesis of mesoporous vanadium oxide by solvothermal and the coprecipitation methods are two approaches that may be explored. [ 49 ] With other methods, the synthesis usually results in larger sizes of particle (>200 nm) and relatively unstable nanostructures. MVONs created using a self‐template design result in a smaller particle size.…”

Section: Nanozyme Reaction Overviewmentioning

confidence: 99%

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Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

et al. 2023

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Reducible metal oxide nanozymes (rNZs) have been a subject of intense recent interest due to their catalytic nature, ease of synthesis, and complex surface character. Such materials contain surface sites which facilitate enzyme‐mimetic reactions via substrate coordination and redox cycling. Further, these surface reactive sites have been shown to be highly sensitive to stresses within the nanomaterial lattice, the physicochemical environment, and to processing conditions occurring as part of their syntheses. When administered in vivo, a complex protein corona binds to the surface, redefining its biological identity and subsequent interactions within the biological system. Catalytic activities of rNZs each deliver a differing impact on protein corona formation, its composition, and in turn, their recognition, and internalization by host cells. Improving our understanding of the precise principles that dominate rNZ surface‐biomolecule adsorption raises the question of whether designer rNZs can be engineered to prevent corona formation, or indeed to produce “custom” protein coronas applied either in vitro, and pre‐administration, or formed immediately upon their exposure to body fluids. Here, we consider fundamental surface chemistry processes and their implications in rNZ material performance. In particular, we discuss material structures which inform component adsorption from the application environment, including substrates for enzyme‐mimetic reactions.This article is protected by copyright. All rights reserved

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Section: Enzyme-mimetic Reactivities and Ph-dependent Activity Of Red...mentioning

confidence: 99%

Section: Enzyme-mimetic Activity Of Rnzs and Protein Interactionmentioning

confidence: 99%

Section: Nanozyme Reaction Overviewmentioning

confidence: 99%

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Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

et al. 2023

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“…Nanozyme is a kind of nanomaterial with enzyme-like activity, which can mimic the catalytic activity of natural enzyme under physiological condition while possessing the properties of ROS production also be widely researched, such as oxidovanadium (IV) complex VOL, vanadium−flavonoid complexes, vanadium pentoxide, vanadyl sulphate, etc. [13][14][15][16][17] To date, the application of vanadium-based nanozyme in cancer treatment is still relatively rare.…”

Section: Introductionmentioning

confidence: 99%

“…[ 12 ] In addition, the bioactivity of various V compounds related to ROS production also be widely researched, such as oxidovanadium (IV) complex VOL, vanadium−flavonoid complexes, vanadium pentoxide, vanadyl sulphate, etc. [ 13–17 ] To date, the application of vanadium‐based nanozyme in cancer treatment is still relatively rare.…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment‐Responsive Nanocarrier Based on VO_x Nanozyme Amplify Oxidative Stress for Tumor Therapy

Zhang

Cheng

Huang

et al. 2023

Adv Funct Materials

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The construction of a novel nanocarrier that can break the redox balance in tumor cell is a promising anti-tumor strategy. Herein, a tumor microenvironment (TME)-responsive nanocarrier VC@Lipo is rationally designed by embedding ultrasmall VO x nanozyme and photosensitizer chlorin e6 (Ce6) into liposomes. The size of VC@Lipo nanocarrier is ≈35 nm and can be degraded in the weakly acidic environment of TME. The VO x nanozyme exhibits peroxidase-like activity and generates highly toxic hydroxyl radical •OH through Fenton-like reaction and 1 O 2 in the presence of H 2 O 2 independent of light, and more 1 O 2 can be generated by the photodynamic effect of Ce6. In addition, the VO x nanozyme can effectively deplete intracellular overexpressed glutathione (GSH) through redox reactions. In vivo experiments demonstrate that the nanocarrier shows excellent biocompatibility, presents the largest enrichment at the tumor site after 6 h of intravenous injection into mice with the highest tumor inhibition rate of 54.18% after laser irradiation. Compared with the single treatment mode, VC@Lipo shows the best synergistic effect of chemodynamic-photodynamic therapy. This work provides a new paradigm for nanocatalytic therapy of cancer and is expected to provide new ideas for precision medicine in cancer.

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Vanadium

Gad

2023

Patty's Toxicology

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Vanadium (V) is the most biologically active and the most naturally present of the group V transition metals forming a range of compounds and acting as either a cation or an anion. It is widely used in steel alloys. It has antiviral, antibacterial, antifungal, anticancer, and antihyperglycemic activities, and since the mid‐2010s, it has come to be used in a number of therapeutics. It has antioxidant properties and influences the metabolism of carbohydrates and at low levels, is an essential nutrient in mammals. Recently, it has become popular in use in nanoparticle form. On the adverse side, it can cause lipid peroxidation and adversely affect mitochondrial respiration. Vanadium pentoxide particulates do cause cancer by a nongenotoxic mechanism.

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Vanadium pentoxide induced oxidative stress and cellular senescence in human lung fibroblasts

Cited by 26 publications

References 89 publications

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

Tumor Microenvironment‐Responsive Nanocarrier Based on VO_x Nanozyme Amplify Oxidative Stress for Tumor Therapy

Vanadium

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Vanadium pentoxide induced oxidative stress and cellular senescence in human lung fibroblasts

Cited by 26 publications

References 89 publications

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

Tumor Microenvironment‐Responsive Nanocarrier Based on VOx Nanozyme Amplify Oxidative Stress for Tumor Therapy

Vanadium

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Tumor Microenvironment‐Responsive Nanocarrier Based on VO_x Nanozyme Amplify Oxidative Stress for Tumor Therapy