Vancomycin and florfenicol resistant Enterococcus faecalis and Enterococcus faecium isolated from human urine in an Egyptian urban-rural community

Osman, Kamelia M.; Zolnikov, Tara Rava; Badr, Jihan M.; Naim, Heba; Hanafy, M.; Saad, Aalaa; Elbehiry, Ayman

doi:10.1016/j.actatropica.2019.105209

Cited by 11 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly, the resistance to linezolid (75.8%) and vancomycin (38.3%) in the study were much higher than that of E. faecalis isolates from duck feces and skin at four slaughterhouses in the southern part of Korea (11 and 0%, respectively) ( Na et al, 2019 ). In addition, the resistance to linezolid of E. faecalis isolated from human urine samples in Egypt is lower than our results, although the isolation rate of Vancomycin-Resistant Enterococcus ( VRE ) from hospital is higher ( Osman et al, 2020 ). For immunocompromised patient, the risk of VRE-related bacteremia and other infections is significantly increased.…”

Section: Discussioncontrasting

confidence: 81%

Molecular characterization of antimicrobial resistance and virulence factors of Enterococcus faecalis from ducks at slaughterhouses

Yang

Wen

et al. 2022

Poultry Science

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 81%

Molecular characterization of antimicrobial resistance and virulence factors of Enterococcus faecalis from ducks at slaughterhouses

Yang

Wen

et al. 2022

Poultry Science

View full text Add to dashboard Cite

“…In addition, in most of our study MRSA strains, cfr co-expressed with the erm gene (erythromycin resistance) that has a significant correlation with biofilm formations (Beceiro et al, 2013;Li et al, 2018). Previous studies in Enterococcus species exhibited that strong biofilm formation was more prevalent among linezolidresistant compared with -sensitive isolates (Osman et al, 2020). S. aureus is a highly adaptable bacterium capable of dynamic changes in its virulence and resistance phenotypes when exposure to the host defenses or antibiotics (Abdelhady et al, 2015).…”

Section: Discussionmentioning

confidence: 78%

Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection

Zhou

Tao

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

Linezolid resistance mediated by the cfr gene in MRSA represents a global concern. We investigated relevant phenotype differences between cfr-positive and -negative MRSA that contribute to pathogenesis, and the efficacy of linezolid-based combination therapies in murine models of bacteremia and skin and skin structure infection (SSSI). As a group, cfr-positive MRSA exhibited significantly reduced susceptibilities to the host defense peptides tPMPs, human neutrophil peptide-1 (hNP-1), and cathelicidin LL-37 (P < 0.01). In addition, increased binding to fibronectin (FN) and endothelial cells paralleled robust biofilm formation in cfr-positive vs. -negative MRSA. In vitro phenotypes of cfr-positive MRSA translated into poor outcomes of linezolid monotherapy in vivo in murine bacteremia and SSSI models. Importantly, rifampicin showed synergistic activity as a combinatorial partner with linezolid, and the EC 50 of linezolid decreased 6-fold in the presence of rifampicin. Furthermore, this combination therapy displayed efficacy against cfr-positive MRSA at clinically relevant doses. Altogether, these data suggest that the use of linezolid in combination with rifampicin poses a viable therapeutic alternative for bacteremia and SSSI caused by cfr-positive multidrug resistant MRSA.

show abstract

“…The emergence of VREs in food-animal production systems has been largely attributed to the heavily use of avoparcin as a growth promoter ( 40 ). Even though the use of growth-promoting antibiotics in farm animals has been banned since 1997, high rates of VRE carriage have been reported globally in economic animals, as well as in companion and laboratory animals ( 41 ) as well as wildlife ( 42 ), and which might act as reservoir populations ( 43 – 54 ). Accordingly, the continuous long-term monitoring of a broader range of microbiome and resistomes between captive and free-ranging wildlife for enterococcal species as well as other vancomycin-resistant genes dispersal is clearly required.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Gut Microbiome and Resistomes of Wild and Zoo-Captive Macaques

et al. 2022

View full text Add to dashboard Cite

Rhesus macaques (Macaca mulatta) are the most widely distributed species of Old World monkey and are frequently used as animal models to study human health and disease. Their gastrointestinal microbial community likely plays a major role in their physiology, ecology and evolution. Herein, we compared the fecal microbiome and antibiotic resistance genes in 15 free-ranging and 81 zoo-captive rhesus macaques sampled from two zoos in China, using both 16S amplicon sequencing and whole genome shotgun DNA sequencing approaches. Our data revealed similar levels of microbial diversity/richness among the three groups, although the composition of each group differed significantly and were particularly marked between the two zoo-captive and one wild groups. Zoo-captive animals also demonstrated a greater abundance and diversity of antibiotic genes. Through whole genome shotgun sequencing we also identified a mammalian (simian) associated adenovirus. Overall, this study provides a comprehensive analysis of resistomes and microbiomes in zoo-captive and free-ranging monkeys, revealing that semi-captive wildlife might harbor a higher diversity of antimicrobial resistant genes.

show abstract

Vancomycin and florfenicol resistant Enterococcus faecalis and Enterococcus faecium isolated from human urine in an Egyptian urban-rural community

Cited by 11 publications

References 6 publications

Molecular characterization of antimicrobial resistance and virulence factors of Enterococcus faecalis from ducks at slaughterhouses

Molecular characterization of antimicrobial resistance and virulence factors of Enterococcus faecalis from ducks at slaughterhouses

Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection

Characterization of the Gut Microbiome and Resistomes of Wild and Zoo-Captive Macaques

Contact Info

Product

Resources

About