Vancomycin Capped with Silver Nanoparticles as an Antibacterial Agent against Multi-Drug Resistance Bacteria

Esmaeillou, M; Zarrini, Gholamreza; Rezaee, Mohammad Ahangarzadeh; J, Shahbazi mojarrad; Bahadori, Alireza

doi:10.15171/apb.2017.058

Cited by 62 publications

(49 citation statements)

References 12 publications

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“…Besides the broad-spectrum antibacterial properties that NPs have against Gram-positive and -negative bacteria, NPs have been used as vectors for the delivery of antimicrobial moieties that greatly improve their biocidal properties (Beyth et al, 2015 ; Rai A. et al, 2016 ; Singh J. et al, 2016 ; Esmaeillou et al, 2017 ; Wang et al, 2017a ; Zaidi et al, 2017 ; Hadiya et al, 2018 ). Some of the advantages of using NPs as vectors are due to their small and controllable size; their protective action against enzymes that would otherwise destroy antimicrobial compounds; their ability to actively deliver antibiotics; and their capability to combine several therapeutic modalities onto a single nanomaterial ( e.g ., several antibiotics/compounds onto the same NPs for combined action; combining silencing agents and drugs, etc.)…”

Section: Nanomaterials Against Bacteriamentioning

confidence: 99%

“…Some of the advantages of using NPs as vectors are due to their small and controllable size; their protective action against enzymes that would otherwise destroy antimicrobial compounds; their ability to actively deliver antibiotics; and their capability to combine several therapeutic modalities onto a single nanomaterial ( e.g ., several antibiotics/compounds onto the same NPs for combined action; combining silencing agents and drugs, etc.) (Turos et al, 2007 ; Huh and Kwon, 2011 ; Mohammed Fayaz et al, 2011 ; Liu et al, 2013 ; Qi et al, 2013 ; Li et al, 2014 ; Ranghar et al, 2014 ; Thomas et al, 2014 ; Wang et al, 2014 ; Payne et al, 2016 ; Rai A. et al, 2016 ; Singh J. et al, 2016 ; Yeom et al, 2016 ; Esmaeillou et al, 2017 ; Zaidi et al, 2017 ; Zong et al, 2017 ; Hadiya et al, 2018 ).…”

Section: Nanomaterials Against Bacteriamentioning

confidence: 99%

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Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.

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Section: Nanomaterials Against Bacteriamentioning

confidence: 99%

Section: Nanomaterials Against Bacteriamentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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“…These bactericidal pathways help the nanomaterials to overcome the antibiotic-resistant mechanism. Esmaeillou et al (2017), demonstrated that the silver nanoparticles could overcome the vancomycin-resistant in cases of S. aureus through binding with the vancomycin and enhancing bacterial cell death. Also, Saeb et al (2014), reported that silver nanoparticles could avoid the methicillin-resistant in cases of S. aureus through binding with the antibiotic.…”

Section: Enhanced Antibacterial Activity Against Resistant S Aureusmentioning

confidence: 99%

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

2020

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Staphylococcus aureus (S. aureus) is one of the most important zoonotic bacterial pathogens, infecting human beings and a wide range of animals, in particular, dairy cattle. Globally. S. aureus causing bovine mastitis is one of the biggest problems and an economic burden facing the dairy industry with a strong negative impact on animal welfare, productivity, and food safety. Furthermore, its smart pathogenesis, including facultative intracellular parasitism, increasingly serious antimicrobial resistance, and biofilm formation, make it challenging to be treated by conventional therapy. Therefore, the development of nanoparticles, especially liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanogels, and inorganic nanoparticles, are gaining traction and excellent tools for overcoming the therapeutic difficulty accompanied by S. aureus mastitis. Therefore, in this review, the current progress and challenges of nanoparticles in enhancing the S. aureus mastitis therapy are focused stepwise. Firstly, the S. aureus treatment difficulties by the antimicrobial drugs are analyzed. Secondly, the advantages of nanoparticles in the treatment of S. aureus mastitis, including improving the penetration and accumulation of their payload drugs intracellular, decreasing the antimicrobial resistance, and preventing the biofilm formation, are also summarized. Thirdly, the progression of different types from the nanoparticles for controlling the S. aureus mastitis are provided. Finally, the difficulties that need to be solved, and future prospects of nanoparticles for S. aureus mastitis treatment are highlighted. This review will provide the readers with enough information about the challenges of the nanosystem to help them to design and fabricate more efficient nanoformulations against S. aureus infections. ARTICLE HISTORY ). So, these new nanocarriers provide a new strategy to combat S. aureus mastitis problems. In order to provide an overview of the emerging nanocarriers in the bovine mastitis management and help the researcher to understand how they can discover a new trend to combat S. aureus mastitis by shifting their attention toward the world of nanocarriers. We searched PubMed, Scopus, and Web of Science for all the studies published over the last 20 years using the keywords "S. aureus mastitis" or "virulence factors of S. aureus" and "antimicrobial resistance" or "nanoparticles and nanogel". About 3000 records and 550 of closely related papers were screened for suitable studies. We summarized the features and treatment difficulty of S. aureus mastitis, the advantages, and prospects of nanoparticles and nanogels according to the related publications.

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“…The antimicrobial activity of our synthesized PVP-AgNPs is comparable to other reported in different studies, using similar culture conditions. MIC values in the literature range from 0.8 µg mL -1 to 13.5 µg mL -1 for S. aureus (Table S1, supplementary material) (13,28), and from 0.4 µg mL -1 to 40 µg mL -1 for C. albicans (Table S2, supplementary material) (29,30). The physicochemical properties of AgNPs depend upon their morphology and capping agent; yet different AgNPs with different traits may display close antimicrobial activity (19).…”

Section: Resultsmentioning

confidence: 99%

A fast and simple protocol for synthesizing effective antimicrobial silver nanoparticles in non-specialized facilities

Vázquez-Muñoz

Arellano-Jiménez

López-Ribot

2019

Preprint

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Objective Silver nanoparticles (AgNPs) can be difficult or expensive to obtain or synthesize for laboratories in resource-limited facilities. The purpose of this work was to create a fast, facile, and cost-effective method for synthesizing AgNPs with potent antimicrobial properties, that can be readily implemented in non-specialized laboratories.Results Our developed method uses a rather simple and rapid chemical reduction process that involves the addition of a polyvinylpyrrolidone solution to a warmed silver nitrate solution under constant vigorous stirring, immediately followed by the addition of sodium borohydride with constant stirring for an additional 15 minutes. AgNPs had an aspect ratio close to 1, with an average size of 6.18 ± 5 nm. AgNPs displayed potent antimicrobial activity, with Minimal Inhibitory Concentration values of 3 µg mL-1 and 1.5 µg mL-1 for Staphylococcus aureus and Candida albicans respectively.Keywords : Silver nanoparticles, nanoantibiotics, synthesis method, AgNPs, metallic nanoparticles

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Vancomycin Capped with Silver Nanoparticles as an Antibacterial Agent against Multi-Drug Resistance Bacteria

Cited by 62 publications

References 12 publications

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

A fast and simple protocol for synthesizing effective antimicrobial silver nanoparticles in non-specialized facilities

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