Vancomycin loaded superparamagnetic MnFe 2 O 4 nanoparticles coated with PEGylated chitosan to enhance antibacterial activity

Esmaeili, Akbar; Ghobadianpour, Sepideh

doi:10.1016/j.ijpharm.2016.02.013

Cited by 95 publications

(48 citation statements)

References 23 publications

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“…Vancomycin was selected for binding to the Fe 3 O 4 @SiO 2 @Ag microflowers to maximize the bactericidal potential; this antibiotic exhibits a wellestablished mechanism and synergistic antibacterial effects with various types of NPs. 34,35 Vancomycin can directly bind to the terminal D-Ala-D-Ala portion of the peptidoglycan of the cell wall of a Gram-positive bacterium through hydrogen bonds to inhibit peptidoglycan synthesis. Moreover, previous studies have demonstrated that vancomycin-modified NPs elicit enhanced antimicrobial activities or can electively capture not only Gram-positive but also Gram-negative bacterium.…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-modified Fe3O4@SiO2@Ag microflowers as effective antimicrobial agents

Wang

Zhang²,

Zhou³

et al. 2017

IJN

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Nanomaterials combined with antibiotics exhibit synergistic effects and have gained increasing interest as promising antimicrobial agents. In this study, vancomycin-modified magnetic-based silver microflowers (Van/Fe 3 O 4 @SiO 2 @Ag microflowers) were rationally designed and prepared to achieve strong bactericidal ability, a wide antimicrobial spectrum, and good recyclability. High-performance Fe 3 O 4 @SiO 2 @Ag microflowers served as a multifunction-supporting matrix and exhibited sufficient magnetic response property due to their 200 nm Fe 3 O 4 core. The microflowers also possessed a highly branched flower-like Ag shell that provided a large surface area for effective Ag ion release and bacterial contact. The modified-vancomycin layer was effectively bound to the cell wall of bacteria to increase the permeability of the cell membrane and facilitate the entry of the Ag ions into the bacterium, resulting in cell death. As such, the fabricated Van/Fe 3 O 4 @SiO 2 @Ag microflowers were predicted to be an effective and environment-friendly antibacterial agent. This hypothesis was verified through sterilization of Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus , with minimum inhibitory concentrations of 10 and 20 μg mL −1 , respectively. The microflowers also showed enhanced effect compared with bare Fe 3 O 4 @SiO 2 @Ag microflowers and free-form vancomycin, confirming the synergistic effects of the combination of the two components. Moreover, the antimicrobial effect was maintained at more than 90% after five cycling assays, indicating the high stability of the product. These findings reveal that Van/Fe 3 O 4 @SiO 2 @Ag microflowers exhibit promising applications in the antibacterial fields.

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Section: Introductionmentioning

confidence: 99%

Vancomycin-modified Fe3O4@SiO2@Ag microflowers as effective antimicrobial agents

Wang

Zhang²,

Zhou³

et al. 2017

IJN

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“…LBL self‐assembly technique involves preparation of polyelectrolyte multilayer films and is based on sequential adsorption of multiple polyion films. The concept of LBL self‐assembly was first introduced by Iler in 1966, who described the formation of multilayers by alternate deposition of positively and negatively charged colloid particles . Different materials such as polyelectrolytes, proteins, ions, polymers, and lipids can be applied as shell in LBL .…”

Section: Introductionmentioning

confidence: 99%

“…In 2015, Esmaeili and Hadad coated zinc ferrite nanoparticles with chitosan for delivery of doxorubicin to target cancer cells . Sodium alginate, a negatively charged natural polysaccharide that is nontoxic, biocompatible, and has a relatively low cost, is used in drug delivery . In 1998, Sukhorukov et al were the first to apply an LBL assembly of polymeric films to the surface of decomposable cores to prepare polyelectrolyte capsules .…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Esmaeili

Khodaei

2017

J Biomedical Materials Res

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Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Given by mouth or intravenously, it can cause numerous clinical drug interactions; thus, alternative systems of drug delivery that bypass some or all of its toxic effects are well worth investigating. In this study, a controlled layer-by-layer (LBL) process of encapsulating RIF in biocompatible alginate and chitosan polymers loaded onto Fe O nanoparticles was developed. Fe O nanoparticles were synthesized from FeCl ·6H O using a hydrothermal procedure. Fluorescent molecular beacons containing RIF molecules and Texas Red were loaded onto the surfaces of Fe O nanoparticles. The loaded nanoparticles were encapsulated in alginate and chitosan layers with alternating negative and positive surface charge using an LBL self-assembly method. Subsequently, by removing the Fe O template particles, polymeric capsules containing RIF were obtained. Ultraviolet-visible spectrophotometry employed to determine optimized conditions for loading RIF, measure the amount of RIF loaded onto the surface of the nanoparticles under optimized conditions, and study drug-release capability. Scanning electron microscopy was used to characterize the morphology of unloaded and loaded nanoparticles. X-ray diffraction and Fourier transform infrared spectroscopy were applied to demonstrate the production of nanoparticles and loading of RIF onto them. Zeta potential analysis was used to determine the size and surface potential of the loaded polymeric layers. After removal of the core template, confocal fluorescence microscopy was used to isolate polymeric capsules containing RIF. The average size of the nanoparticles obtained was 23 nm. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 905-913, 2018.

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“…The polymeric nanocarriers release the drug at the site of action by one of three general physicochemical mechanisms: (i) via swelling of the polymer nanoparticles by hydration, (ii) by an enzymatic reaction resulting in the cleavage of bonds and degradation of the polymer at the site of delivery and (iii) by de-adsorption of drugs from the swelled nanoparticles [32][33][34] (Figure 1). rials including magnetic nanoparticles, lipid-based and polymeric nanoparticles have been investigated as new treatments against pathogens in planktonic and biofilm form [1][2][3][4][5]. Their use as drug nanocarriers is further supported by the strong antimicrobial activity of the nanostructures [6].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Michalak¹,

Głuszek²,

Piktel³

et al. 2016

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The increased prevalence of antibiotic-resistant pathogens requires additional efforts to develop new antimicrobial agents and alternative methods to prevent and treat infections. In response to this challenge, a variety of nanotechnology-based tools are currently being designed and thoroughly investigated. To date, a considerable number of studies have reported increased activity of antibiotic-conjugated polymeric nanoparticles against bacteria and fungi associated with various infections, including those caused by drug-resistant pathogens. Importantly, high biocompatibility of these structures coupled with enhanced biological activity and improved pharmacokinetic properties supports the potential of these nanosystems as new tools to treat infections. In this review, we summarize the synthesis of polymer-based nanoparticles and describe their mechanism of action. We also highlight the recent advances in the application of antibiotic-conjugated polymeric nanoparticles as novel antimicrobial agents. StreszczenieStale narastająca lekooporność drobnoustrojów wymusza konieczność rozwoju alternatywnych metod profilaktyki i terapii zakażeń, a także uzasadnia prace nad nowymi lekami o aktywności przeciwdrobnoustrojowej. Realizacja tego celu jest moż-liwa dzięki zastosowaniu osiągnięć z zakresu nanotechnologii. Zwiększająca się liczba doniesień literaturowych potwierdza znaczną aktywność przeciwdrobnoustrojową nanocząstek polimerowych skoniugowanych z klasycznymi antybiotykami, co może zostać wykorzystane w terapii infekcji o charakterze bakteryjnym i grzybiczym, również tych wywoływanych przez patogeny lekooporne. Wysoka biokompatybilność nanocząstek polimerowych, a także możliwość zwiększania aktywności przeciwdrobnoustrojowej i poprawy parametrów farmakokinetycznych stosowanych obecnie chemioterapeutyków, wskazuje na możliwość zastosowania nanostruktur w nowoczesnej terapii chorób infekcyjnych. W niniejszej pracy podsumowano metody syntezy nanosystemów opartych na nanocząstkach polimerowych, a także opisano mechanizm ich działania. Przedstawione zostały również najnowsze osiągnięcia w syntezie nanocząstek skoniugowanych z antybiotykami, pozwalające na ich zastosowanie w terapii infekcji o charakterze bakteryjnym i grzybiczym.

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Vancomycin loaded superparamagnetic MnFe 2 O 4 nanoparticles coated with PEGylated chitosan to enhance antibacterial activity

Cited by 95 publications

References 23 publications

Vancomycin-modified Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Ag microflowers as effective antimicrobial agents

Vancomycin-modified Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Ag microflowers as effective antimicrobial agents

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

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