Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid

Zheng, Ningning; Gu, Yu; Hong, Ying; Sheng, Lili; Chen, Linlin; Zhang, Feng; Hou, Jie; Zhang, Weidong; Zhang, Zean; Wang, Jia; Li, Houkai

doi:10.1016/j.jpha.2019.11.003

Cited by 23 publications

(20 citation statements)

References 33 publications

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“…Zheng et al changed the composition of the gut microbiota in mice using vancomycin, which reduced the abundance of Gram-positive bacteria in the intestine and increased the level of 2-hydroxybutyric acid in the cecum and serum. The bioavailability of APAP was also decreased and the level of GSH in the liver was increased, which improved the APAP-induced liver injury in mice (Zheng et al, 2020 ). The pharmacokinetics of APAP is also affected by changing the composition of gut bacteria in mice.…”

Section: The Gut Microbiota and Apap-induced Liver Injurymentioning

confidence: 99%

Gut Microbiota and Chemical-Induced Acute Liver Injury

Chen

2021

Front. Physiol.

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Background: Drug overdose or chemical exposures are the main causes of acute liver injury (ALI). Severe liver injury can develop into liver failure that is an important cause of liver-related mortality in intensive care units in most countries. Pharmacological studies have utilized a variety of comprehensive chemical induction models that recapitulate the natural pathogenesis of acute liver injury. Their mechanism is always based on redox imbalance-induced direct hepatotoxicity and massive hepatocyte cell death, which can trigger immune cell activation and recruitment to the liver. However, the pathogenesis of these models has not been fully stated. Many studies showed that gut microbiota plays a crucial role in chemical-induced liver injury. Hepatotoxicity is likely induced by imbalanced microbiota homeostasis, gut mucosal barrier damage, systemic immune activation, microbial-associated molecular patterns, and bacterial metabolites. Meanwhile, many preclinical studies have shown that supplementation with probiotics can improve chemical-induced liver injury. In this review, we highlight the pathogenesis of gut microorganisms in chemical-induced acute liver injury animal models and explore the protective mechanism of exogenous microbial supplements on acute liver injury.

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Section: The Gut Microbiota and Apap-induced Liver Injurymentioning

confidence: 99%

Gut Microbiota and Chemical-Induced Acute Liver Injury

Chen

2021

Front. Physiol.

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“…Nrf-2 is a transcription factor that improves redox defense by endorsing the transcriptions of antioxidant enzymes, thus exhibiting protection against APAP toxicity [ 73 ]. In another report, Zheng and colleagues (2020) showed that a reduction in gram-positive count in the intestine by vancomycin treatment in experimental mice could increase the 2-hydroxybutyric acid level in the cecum and serum, resulting in a decrease in APAP bioavailability and an increase in GSH level to ameliorate APAP hepatotoxicity [ 74 ]. Thus, the pharmacokinetics of APAP can be affected by changes in the abundance, and/or diversity, of gut microbiota.…”

Section: Emerging Role Of the Gut Microbiota In Apap Hepatotoxicitymentioning

confidence: 99%

Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity

et al. 2022

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Acetaminophen (APAP) is the most common prescription medicine around the world for the treatment of pain and fever and is considered to be a safe drug at its therapeutic dose. However, a single overdose or frequent use of APAP can cause severe acute liver injury. APAP hepatotoxicity is a prevalent cause of acute liver disease around the world and the lack of suitable treatment makes it a serious problem. In recent years, there has been a surge in interest in using probiotics and probiotic-derived products, known as postbiotics, as health and disease negotiators. A growing body of evidence revealed that they can be equally effective against APAP hepatotoxicity. Different probiotic bacteria were found to be pre-clinically effective against APAP hepatotoxicity. Different postbiotics have also shown exciting results in preclinical models of APAP hepatotoxicity. This review summarized the protective roles and mechanisms of the different probiotic bacteria and postbiotics against APAP hepatotoxicity, with critical discussion. A brief discussion on potential novel probiotics and postbiotics for oxidative liver injury was also included. This review was written in an attempt to pique the interest of researchers in developing a safe therapeutic option against oxidative liver damage using probiotics and/or postbiotics as dietary supplements.

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“…Similarly, the changes in intestinal flora diversity and abundance could also affect the metabolism of APAP. Vancomycin decreased the bioavailability of APAP after changing the composition of intestinal microflora in mice, thereby alleviating the liver injury of APAP [7]. The pharmacokinetics of APAP was also affected by the changes in intestinal bacterial composition in mice.…”

Section: Introductionmentioning

confidence: 99%

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Hao

Chen

et al. 2022

Nutrients

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Liver injury caused by an overdose of acetaminophen (APAP) is a major public health problem. This study aimed to evaluate the effects of Broussonetia papyrifera polysaccharide (BPP) on liver injury and intestinal flora induced by APAP. The results showed that BPP could protect against APAP-induced liver injury, alleviate liver apoptosis, improve antioxidant capacity and enhance the liver’s detoxification ability to APAP. At the same time, BPP improved the intestinal flora disorder caused by APAP. More importantly, we found that the hepatoprotective effect of BPP disappeared after the depletion of gut microbiota in mice. Further, we reconstructed the intestinal flora structure of mice through fecal microbiota transplantation and found that the symptoms of APAP—induced liver injury were effectively alleviated. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury and might be mediated by intestinal flora.

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Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid

Cited by 23 publications

References 33 publications

Gut Microbiota and Chemical-Induced Acute Liver Injury

Gut Microbiota and Chemical-Induced Acute Liver Injury

Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

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