Vancomycin-resistant enterococci among clinical isolates from north-west Iran: identification of therapeutic surrogates

Sharifi, Yaeghob; Hasani, Alka; Ghotaslou, Reza; Varshochi, Mojtaba; Hasani, Akbar; Soroush, Mohammad Hossein; Aghazadeh, Mohammad; Milani, Morteza

doi:10.1099/jmm.0.036780-0

Cited by 18 publications

(14 citation statements)

References 11 publications

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“…Of note, although vancomycin is an accepted antibiotic for the treatment of Gram-positive cocci, it exerts only bacteriostatic activity against enterococci and needs to be combined with another agent, usually an aminoglycoside, to achieve bactericidal activity (17). Unfortunately, high resistance to erythromycin, clindamycin, and tetracycline (74.5%, 97.2%, and 89%, respectively) were observed in this study, which was consistent with the results of other studies in Iran and other countries (2,5,7,13,14,16). This finding suggests that antimicrobial resistance must be considered when determining treatment of patients.…”

Section: Discussionsupporting

confidence: 82%

“…In this study, the majority of enterococcal isolates were obtained from urine samples, consistent with other reports (2,5,14). Moreover, it has been shown that enterococcal UTI is more common in people aged 65 years or older, which can be attributed to the increased frequency of genitourinary anomalies and obstructive uropathy in this age (3).…”

Section: Discussionsupporting

confidence: 76%

“…Vancomycin-resistant enterococci (VRE) are recognized as important resistant pathogens worldwide (3,4), including in Iran (5)(6)(7)(8)(9). Infections caused by VRE are associated with severe adverse outcomes such as extended hospital stay, increased treatment cost, and increased mortality due to reduction in the antimicrobial agents available to treat infections (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Susceptibility Pattern of Enterococci Isolated From Patients in Tehran

Saderi¹,

Hosseini²,

Moosavi³

et al. 2015

Int J Enteric Pathog

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Background: Enterococci are one of the most common nosocomial pathogens and the emergence of multidrug-resistant strains has been increasing. Objectives: We studied the antimicrobial susceptibility of enterococci isolated from different clinical specimens of patients in Tehran. Materials and Methods: From the beginning of April 2013 to the end of June 2013, a total of 146 enterococci were isolated from the Pars General Hospital in Tehran. The antimicrobial susceptibility pattern of the isolates against ampicillin, clindamaycin, ciprofloxacin, erythromycin, levofloxacin, linezolid, nitrofurantoin, tetracycline, and vancomycin was determined using the disk diffusion method according to the guidelines of clinical laboratory standards institute (CLSI). Results: The rates of resistance were high to clindamycin, tetracycline, and erythromycin (97.2%, 89%, and 74.5%, respectively); moderate to ciprofloxacilin and levofloxacilin (40.6% and 36.4%, respectively); and low to ampicillin and nitrofurantoin (13.8% and 3.5%, respectively). All isolates were linezolid sensitive. Vancomycin-resistant enterococci (VRE) accounted for 9.6% of the isolates. Conclusions: VRE and a high rate of resistance to some of antimicrobial agents were found among the enterococci isolated from patients in Tehran. These findings highlight the importance of regular supervision of antimicrobial susceptibilities.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Susceptibility Pattern of Enterococci Isolated From Patients in Tehran

Saderi¹,

Hosseini²,

Moosavi³

et al. 2015

Int J Enteric Pathog

View full text Add to dashboard Cite

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“…According to our analysis, the rate of vancomycin resistance among E. faecalis isolates was higher than for E. faecium. This finding could be explained by the fact that E. faecalis was the dominant species isolated from infections [5,9,10].…”

Section: Discussionmentioning

confidence: 90%

“…Infections due to VRE are significantly associated with an increased rate of morbidity, mortality, prolonged hospitalization, and elevated cost burden [7]. Based on the aforementioned data, the prevalence rates of VRE in clinical samples has been reported in several scientific works in Iran [5,[8][9][10][11][12]. However, most of these studies have shown local information, and a comprehensive analysis from different parts of Iran has not yet been performed.…”

Section: Introductionmentioning

confidence: 95%

Prevalence of vancomycin-resistant Enterococcus in Iran: a systematic review and meta-analysis

Emaneini

Hosseinkhani

Jabalameli

et al. 2016

Eur J Clin Microbiol Infect Dis

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Vancomycin-resistant Enterococcus (VRE) is considered to be a major nosocomial pathogen that results in serious morbidity and mortality worldwide. Limited information is available concerning the prevalence of VRE infections in Iran. We carried out a systematic search by using different electronic databases including: Medline (via PubMed), Embase, Web of Science, and the Iranian Database. Meta-analysis was performed using comprehensive meta-analysis software. The meta-analyses revealed that the prevalence of VRE infections was 9.4 % (95 % confidence interval [95 % CI] 7.3-12) among culture-positive cases for Enterococcus species. The prevalence of VRE in Iran is compared with the results of developed countries. The prevalence of VRE in Germany, the United Kingdom (UK), and Italy was 11.2 %, 8.5-12.5 %, and 9 % respectively. Additionally, the frequency of vancomycin resistance among E. faecalis isolates was higher than for E. faecium. The results of this study indicate that a comprehensive infection control strategy based on hand hygiene, educating the hospital staff members, providing clinical guidance and principles for the appropriate use of antibiotics, sanitizing the hospitals, contact precautions, and active surveillance systems on the basis of international criteria is urgently needed.

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Comparative analysis of Enterococcus faecalis and Enterococcus faecium strains isolated from clinical samples and traditional cheese types in the Northwest of Iran: antimicrobial susceptibility and virulence traits

et al. 2019

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Vancomycin-resistant enterococci among clinical isolates from north-west Iran: identification of therapeutic surrogates

Cited by 18 publications

References 11 publications

Antimicrobial Susceptibility Pattern of Enterococci Isolated From Patients in Tehran

Antimicrobial Susceptibility Pattern of Enterococci Isolated From Patients in Tehran

Prevalence of vancomycin-resistant Enterococcus in Iran: a systematic review and meta-analysis

Comparative analysis of Enterococcus faecalis and Enterococcus faecium strains isolated from clinical samples and traditional cheese types in the Northwest of Iran: antimicrobial susceptibility and virulence traits

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