Vancomycin versus Linezolid in the Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Meningitis

Sıpahi, Oğuz Reşat; Bardak-Özcem, Selin; Turhan, Tuncer; Arda, Bilgin; Rükşen, Mete; Pullukçu, Hüsnü; Aydemir, Şöhret; Dalbastı, Tayfun; Yurtseven, Taşkın; Sipahi, Hilal; Zılelı, Mehmet; Ulusoy, Sercan

doi:10.1089/sur.2012.091

Cited by 26 publications

(21 citation statements)

References 11 publications

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“…We have found that all MRSA isolates tested in the present study were fully sensitive to vancomycin so it may be used as the drug of choice for treating multidrug-resistant MRSA infections. Similar findings were reported by various previous studies (Singh et al 2013 ; Sipahi et al 2013 ; Bhatt et al 2014 ; Chelliah et al 2014 ). In addition, all isolates were sensitive to linezolid which is in line with other studies (Sipahi et al 2013 ; Vijayamohan and Nair 2014 ).…”

Section: Discussionsupporting

confidence: 91%

High frequency of methicillin-resistant Staphylococcus aureus in Peshawar Region of Pakistan

et al. 2016

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Staphylococcus aureus is an increasing problem in clinical practice because of reduced susceptibility to available antibiotics. The objective of the study was to determine the frequency of Methicillin-resistant S.aureus (MRSA) in Peshawar, Pakistan. Clinical isolates of S. aureus were subjected to determination of antibiotic resistance, MICs and inducible clindamycin resistance (ICR). Out of total 280 S. aureus isolates, the frequency of MRSA was 36.1 % (n = 101). MRSA infection was found higher among the age group 50–59 years (60.71 %, OR 3.09), followed by 20–29 years (47.5 %, OR 1.74). Frequency of MRSA in female and male was 39.8 and 34 % respectively. MRSA was more frequent in blood specimens (48.7 %, OR 2.14). The frequency of community and hospital acquired MRSA was 42 and 34.8 % respectively. MRSA showed high resistance (100 %) to penicillin and cefoxitin followed by erythromycin (99 %). While MRSA exhibited 100 % susceptibility to vancomycin and linezolid. We have also found 7 vancomycin intermediate sensitive S. aureus (VISA) isolates. ICR was observed in 15.84 % (n = 16) of MRSA isolates. It is concluded that MRSA is potential threat to public health in Peshawar. Vancomycin and linezolid could be prescribed as a drug of choice in treating MRSA associated infections. In addition, ICR should be routinely checked to avoid clindamycin treatment failure.

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Section: Discussionsupporting

confidence: 91%

High frequency of methicillin-resistant Staphylococcus aureus in Peshawar Region of Pakistan

et al. 2016

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“…It remains off licence for treating infections of the central nervous system (CNS) 15. Existing case series have shown promising outcomes for SEAs and CNS infections treated with linezolid,7 16 including those caused by methicillin-resistant S. aureus ,17 the incidence of which (SEAs) has been reported to be increasing 2. Resolution of meningitis in a 67-year-old patient caused by GBS has been reported after treatment with linezolid in conjunction with meropenem, where improvement occurred after linezolid was given 18.…”

Section: Discussionmentioning

confidence: 99%

Resolution of group B streptococcal panspinal epidural abscess in a patient with diabetes after treatment with ceftriaxone and linezolid

et al. 2019

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Panspinal epidural abscesses are an extremely rare yet potentially fatal condition. Whether cases are best managed surgically or medically is currently controversial. A 63-year-old patient with diabetes presented initially with abdominal pain, back pain, urinary retention and constipation. He subsequently developed fevers, radicular pain and new-onset weakness in the right leg. MRI confirmed a panspinal epidural abscess extending from C7 to L5, with group B Streptococcus (GBS) cultured on sampling. Due to the significant risks of surgery he was managed conservatively, initially with ceftriaxone, and subsequently in combination with linezolid. Repeat MRI 3 months after presentation revealed complete resolution of the abscess. This case illustrates how conservative management is a valid option for patients with this condition, and supports the use of synergistic linezolid in this scenario. It also highlights how some cases may not initially present with the classically described triad of fever, back pain and loss of neurological function.

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“…Nosocomial meningitis was defined as bacterial infection not present when the patient was admitted to the hospital or clinical evidence of infection within a short period of time after discharge from the hospital where the patient had received an invasive procedure. Patients developing meningitis after neurosurgical procedures were defined as having postneurosurgical infection [11,20]. Accordingly, all cases had nosocomial post neurosurgical meningitis.…”

Section: Accepted Manuscript 2 Materials and Methodsmentioning

confidence: 99%

“…In spite of developments in neurosurgery, antimicrobial agents, medicine and intensive care, meningitis, as well as nosocomial or healthcare-associated meningitis (HCAM), are still associated with significant mortality and morbidity[1][2][3][4][5][6][7][8][9][10][11]. Multidrug-resistant (MDR) as well as carbapenem-resistant Acinetobacter baumannii (CRAB)…”

mentioning

confidence: 99%

Tigecycline in the treatment of multidrug-resistant Acinetobacter baumannii meningitis: Results of the Ege study

Sıpahi

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Demırdal

et al. 2018

Clinical Neurology and Neurosurgery

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Vancomycin versus Linezolid in the Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis

Cited by 26 publications

References 11 publications

High frequency of methicillin-resistant Staphylococcus aureus in Peshawar Region of Pakistan

High frequency of methicillin-resistant Staphylococcus aureus in Peshawar Region of Pakistan

Resolution of group B streptococcal panspinal epidural abscess in a patient with diabetes after treatment with ceftriaxone and linezolid

Tigecycline in the treatment of multidrug-resistant Acinetobacter baumannii meningitis: Results of the Ege study

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