Vanek’s tumor (inflammatory fibroid polyp). Report of 18 cases and comparison with three cases of original Vanek’s series

Daum, Ondřej; Hes, Ondřej; Vaněček, Tomáš; Beneš, Zdeněk; Šíma, Radek; Zámečnı́k, Michal; Mukenšnábl, Petr; Hadravská, Šárka; Curík, R; Michal, Michal

doi:10.1016/j.anndiagpath.2003.09.003

Cited by 61 publications

(48 citation statements)

References 23 publications

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“…Additionally, characteristic short spindle cells intermixed with abundant inflammatory cells can be seen. These identifiable features corresponded well to the histologic diagnosis in the H&E-stained images ( Figure 1B), which it is formed by a spindle cell proliferation surrounding blood vessels in a concentric form (onion skin like structures), inflammatory lymphocytic infiltrate with abundant eosinophils [19] . In order to understand the morphological structure of tissue slices at different depths, a series of optical sectioning images were obtained at intervals of 1.15 μ m up to a final depth of 16.1 μ m (Figure 2 ).…”

Section: Methodssupporting

confidence: 76%

Multi-photon microscopic imaging of inflammatory fibroid polyps/Multi-Photonen-Mikroskopie entzündlich fibroider Polypen

Kang¹,

Xu²,

Jiang³

et al. 2013

Photonics &Amp; Lasers in Medicine

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Background and objective: Most applications of multiphoton microscopy (MPM) in biology and medicine focus on high-resolution imaging of physiology, morphology and cell -cell interactions in intact tissues or live animals. In this paper, our aim is to assess whether MPM has the ability to provide comparable information for stained histology slides and to identify inflammatory fibroid polyp (IFP) tissue sections without H&E staining. Materials and methods: A tissue section without H&E staining was examined using a multi-photon microscope consisting of a mode-locked Ti: sapphire femtosecond laser (Mira 900-F; Coherent, Inc.) and a commercial laser scanning microscope (LSM 510 META; Carl Zeiss, Inc.) with a Plan-Neofluar 40 × /0.75 objective. Large area images and a series of optical sectioning images were obtained using an optional fine-focusing stage (HRZ 200; Carl Zeiss, Inc.). Results: MPM images showed the main characteristics of IFP that corresponded well with H&E microscopic results, such as a typical onion skin arrangement of reticular fibers around thin-walled blood vessels, and short spindle cells intermixed with abundant inflammatory cells. A series of optical sectioning images displayed morphological structure of tissue sections at different depths. Conclusion: MPM has the ability to provide comparable results to H&E staining. Its capability of optical sectioning can present the morphological structure of different optical sectioning planes, making MPM an alternative for those cases where the sample is very thick or cannot be stained.Keywords: multi-photon microscopy (MPM); comparable diagnostic information; histologic diagnosis

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Section: Methodssupporting

confidence: 76%

Multi-photon microscopic imaging of inflammatory fibroid polyps/Multi-Photonen-Mikroskopie entzündlich fibroider Polypen

Kang¹,

Xu²,

Jiang³

et al. 2013

Photonics &Amp; Lasers in Medicine

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“…In fact, like fibrous tumors, inflammatory fibroid polyps may feature a prominent hyalinization, lack of a polypoid shape and, especially in intestinal cases, involvement of visceral layers deeper than submucosa, absence of eosinophils and lack of an onion-skin pattern, and CD34 staining. [31][32][33][34][35] In particular, fibrous tumors resemble the sclerotic stage of inflammatory fibroid polyps described by Kim and Kim. 33 These findings, together with the common PDGFRA-mutant status, in our opinion, well support the inclusion of fibrous tumors in the inflammatory fibroid polyp family.…”

Section: Discussionmentioning

confidence: 99%

PDGFRA-mutant syndrome

et al. 2015

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“…Microscopically, Vanek’s tumours can be mistaken for a variety of lesions, from granulation tissue to high-grade sarcoma. In the differential diagnosis, it is important to include eosinophilic gastro-enteritis, gastro-intestinal stromal tumour, inflammatory pseudo-tumour, haemangioendothelioma and haemangiopericytoma [8]. Endoscopically, Vanek’s tumours are sessile, polypoid lesions usually less than 4 cm in diameter (our case had a big polypoid lesion with a diameter of >5 cm).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Fibroid Polyp or Vanek’s Tumour

et al. 2007

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We report a case of a 65-year-old woman who presented with recurrent episodes of severe, postprandial abdominal pain followed by projectile vomiting. Gastroscopy revealed a large polyp in the prepyloric region. During peristalsis, the polyp was repeatedly ‘passing’ through the pylorus into the duodenal bulb, hence obstructing the lumen. The polyp was eventually removed in a piecemeal fashion. Histopathologic examination revealed an inflammatory fibroid polyp (known also as Vanek’s tumour). A brief review on inflammatory fibroid polyps follows.

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Vanek’s tumor (inflammatory fibroid polyp). Report of 18 cases and comparison with three cases of original Vanek’s series

Cited by 61 publications

References 23 publications

Multi-photon microscopic imaging of inflammatory fibroid polyps/Multi-Photonen-Mikroskopie entzündlich fibroider Polypen

Multi-photon microscopic imaging of inflammatory fibroid polyps/Multi-Photonen-Mikroskopie entzündlich fibroider Polypen

PDGFRA-mutant syndrome

Inflammatory Fibroid Polyp or Vanek’s Tumour

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