Vanillic acid prevents altered ion pumps, ions, inhibits Fas-receptor and caspase mediated apoptosis-signaling pathway and cardiomyocyte death in myocardial infarcted rats

Prince, P. Stanely Mainzen; Dhanasekar, Koothan; Rajakumar, S.

doi:10.1016/j.cbi.2015.03.009

Cited by 43 publications

(17 citation statements)

References 38 publications

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“…Fas plays an important role in the signal transduction in cellular apoptosis. It could bind to its natural ligand FasL, causing the cross-link and subsequent activation of Fas-associated death domain (FADD), further initiating apoptotic process [5]. Studies have shown that the elevated expression of Fas and FasL could enhance cellular apoptosis, while the declined expression could attenuate the apoptotic process [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Zeng

Xiao

et al. 2017

Lipids Health Dis

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BackgroundThe role of 1,25-dihydroxyvitamin D3 (vitamin D) in the apoptosis of diabetic cardiomyopathy (DCM) is unclear. This study is to investigate the effects of vitamin D on the pathological changes in rats with DCM.MethodsRats were randomly divided into the control, model, and treatment groups. DCM model was established by the high-fat and -sugar diet. Plasma glucose, body weight, heart weight, heart weight index, and serum levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were determined. Heart tissue morphology was detected with histochemical staining. Expression levels of Fas and FasL were detected with RT-PCR and immunohistochemistry.ResultsCompared with the control group, the body weights and heart weights were significantly declined, while the plasma glucose levels and heart weight indexes were significantly elevated, in the model group (P < 0.05). However, vitamin D significantly reversed the pathological changes in DCM rats (P < 0.05). Moreover, the serum levels of LDH and CK were significantly increased in the models, which were significantly decreased by vitamin D (P < 0.05). HE staining showed that, vitamin D significantly alleviated the histological changes of myocardial cells in DCM rats. In addition, the mRNA and protein expression levels of Fas and FasL were significantly elevated in the models (P < 0.05), which were significantly declined by vitamin D (P < 0.05).ConclusionVitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in DCM rats, which might be used as a potential effective therapy for the disease.

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Section: Introductionmentioning

confidence: 99%

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Zeng

Xiao

et al. 2017

Lipids Health Dis

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“…Preclinical studies as well as several clinical studies showed that during ischemic damage, oxidative stress produced by the generation of reactive oxygen species (ROS) plays a key role in the development of MI. Ischemia surpasses a serious level in a protracted period in MI and results in permanent myocardial cell injury or death [ 2 ]. MI is the most clinically encountered ischemic heart diseases and remains the foremost reason of death and disability worldwide.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats

Goyal

Sharma

Mahajan

et al. 2015

IJMS

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Cardamom is a popular spice that has been commonly used in cuisines for flavor since ancient times. It has copious health benefits such as improving digestion, stimulating metabolism, and exhibits antioxidant and anti-inflammatory effects. The current study investigated the effect of cardamom on hemodynamic, biochemical, histopathological and ultrastructural changes in isoproterenol (ISO)-induced myocardial infarction. Wistar male albino rats were randomly divided and treated with extract of cardamom (100 and 200 mg/kg per oral) or normal saline for 30 days with concomitant administration of ISO (85 mg/kg, subcutaneous) on 29th and 30th days, at 24 h interval. ISO injections to rats caused cardiac dysfunction evidenced by declined arterial pressure indices, heart rate, contractility and relaxation along with increased preload. ISO also caused a significant decrease in endogenous antioxidants, superoxide dismutase, catalase, glutathione peroxidase, depletion of cardiomyocytes enzymes, creatine kinase-MB, lactate dehydrogenase and increase in lipid peroxidation. All these changes in cardiac and left ventricular function as well as endogenous antioxidants, lipid peroxidation and myocyte enzymes were ameliorated when the rats were pretreated with cardamom. Additionally, the protective effects were strengthened by improved histopathology and ultrastructural changes, which specifies the salvage of cardiomyocytes from the deleterious effects of ISO. The present study findings demonstrate that cardamom significantly protects the myocardium and exerts cardioprotective effects by free radical scavenging and antioxidant activities.

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“…Vanillic acid (22) inhibited Fas-receptor and caspase-mediated apoptosis signaling pathway and so acted as cardioprotective [36]. NCX-1000 (NOreleasing derivative of ursodeoxycholic acid) (23) is a nitric oxide (NO) derivative of ursodeoxycholic acid (UDCA).…”

Section: Fatty Acid Synthase (Fas) Inhibitorsmentioning

confidence: 99%

Apoptotic Inhibitors as Therapeutic Targets for Cell Survival

Abdelhafez¹,

Ali²,

Hassan³

et al. 2019

Cytotoxicity - Definition, Identification, and Cytotoxic Compounds

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Apoptosis has revealed an essential function in the development or prevention of oncogenic transformation in the body; however, programmed cell death (PCD) must be tightly controlled since deregulated cell death is involved in the development of a large number of different pathologies. Apoptosis can be decreased in pathological states such as in cancer and autoimmunity or elevated such as in stroke, neurodegeneration, retinal cell death, myocardial and liver ischemia, inflammatory diseases such as sepsis, osteoarthritis (OA), rheumatoid arthritis (RA), and asthma. Different types of apoptotic inhibitors will be discussed in this chapter displaying their mechanism of action, which have been reported to be therapeutic targets for cell survival or at least limiting cell death. These inhibitors are classified according to their nature into natural antiapoptotic proteins that present mainly in the cell and synthetic small molecule inhibitors that are widely used to protect against overexpression of apoptosis mediators and, in turn, to prevent corresponding diseases.

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Vanillic acid prevents altered ion pumps, ions, inhibits Fas-receptor and caspase mediated apoptosis-signaling pathway and cardiomyocyte death in myocardial infarcted rats

Cited by 43 publications

References 38 publications

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy

Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats

Apoptotic Inhibitors as Therapeutic Targets for Cell Survival

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