Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose–streptozotocin induced diabetic rats

Salau, Veronica F.; Erukainure, Ochuko L.; Olofinsan, Kolawole O.; Msomi, Nontokozo Z.; Ijomone, Omamuyovwi M.; Islam, Md. Shahidul

doi:10.1080/13813455.2021.1988981

Cited by 11 publications

(4 citation statements)

References 65 publications

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“…We suspect glucose may be converted to lactate or other metabolites in the brush border membrane of small intestine cells. Vanillin supplementation has been shown to reduce the levels of some blood metabolites, including glucose, in prior studies [ 65 ]. However, adding vanilla or amyl acetate to the FCPU of growing bulls resulted in no changes in values of serum glucose or urea-N in this study.…”

Section: Resultsmentioning

confidence: 99%

Nutrient digestibility, ruminal fermentation, and blood metabolites of growing cattle-fed fermented cassava pulp with added flavoring agents

Meenongyai,

Wongpanit,

Phongkaew

et al. 2023

J Adv Vet Anim Res

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Objective: This study aimed to assess the effect of adding flavoring agents to fermented cassava pulp (FCPU) on nutrient utilization, ruminal fermentation characteristics, and blood metabolites in growing cattle. Materials and Methods: A duplicated 3 × 3 Latin square design was randomly assigned to six growing beef cattle. Treatments were: 1) untreated FCPU (control), 2) 0.05% w/v vanilla-flavored FCPU, and 3) 0.05% w/v amyl acetate-flavored FCPU. Results: The results showed that flavoring agents did not affect dry matter intake (DMI) or digestibility of nutrients. Rumen pH and ammonia nitrogen concentrations did not change all treat¬ments postfeeding. Flavoring added to FCPU after feeding did not affect total volatile fatty acid (VFA) or VFA percentage. However, propionic acid levels tended to be lower in the vanilla-flavored FCPU group than those in the unflavored FCPU group at 0 h postfeeding (p < 0.01). Growing bulls fed vanilla-flavored FCPU tended to have greater fungal zoospores in the rumen than those fed amyl acetate-flavored FCPU (p < 0.1) at 2 h after feeding. Dietary treatments did not affect blood glucose and urea nitrogen concentrations (p > 0.05). However, blood triglyceride concentration was greater for cattle fed a control diet than other treatments at 0 h postfeeding (p < 0.05) and tended to be higher than those fed vanilla-flavored FCPU at 2 h afterfeeding (p < 0.1). Conclusion: It was suggested that adding vanilla or amyl acetate flavor to the FCPU showed no adverse effects on ruminal fermentation, blood metabolites, or nutritional digestibility; however, it did not increase DMI.

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Section: Resultsmentioning

confidence: 99%

Nutrient digestibility, ruminal fermentation, and blood metabolites of growing cattle-fed fermented cassava pulp with added flavoring agents

Meenongyai,

Wongpanit,

Phongkaew

et al. 2023

J Adv Vet Anim Res

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“…The 3D chemical structure of TryR, SOD, CP and PTR1 with respective access codes 2WPE, 3ESF, 2P7U and 3JQ6 were downloaded from the Protein Data Bank (PDB) 23 . The proteins were prepared for protein-ligand docking with the Dock prep tool of UCFS Chimera software V. 1.14 24 .…”

Section: Molecular Docking Simulationsmentioning

confidence: 99%

Potential anti-HIV and antitrypanosomal components revealed in Sorindeia nitidula via LC-ESI-QTOF-MS/MS and molecular docking

Ebede,

Okoro,

Mbing

et al. 2024

Preprint

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Sorindeia nitidula is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV and antitrypanosomal activities remain unexplored. The present study aims to evaluate the antioxidant, anti-HIV and antitrypanosomal activities of the ethyl acetate extract of S. nitidula (SN) in order to screen out the bioactive compounds and to analyze their possible mechanisms of action. Overall, 21 phenolic compounds were annotated, by using the MS and MS/MS information provided by the QTOF-MS. In vitro assays on the extract revealed potent antioxidant (IC50 = 0.0129 mg/mL), anti-HIV (IC50 = 1.736 mg/mL), antitrypanosomal (IC50 = 1.040 µM) activities. Furthermore, SN did not present cytotoxic effect on HeLa cancer cell lines (IC50 = 0.045 µM). Molecular docking revealed that the potential ligands exhibited strong binding ability and inhibitory activities on trypanosome. The integrated strategy based on LC-ESI-QTOF-MS/MS and molecular docking provided a powerful tool and a multidimensional perspective for further exploration of active ingredients in S. nitidula responsible for the antioxidant, anti-HIV and antitrypanosomal activities.

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“…Vanillin is the main component of vanilla extract and has been commonly used as a flavoring agent or a food additive around the world [7]. Recently, several studies have suggested that vanillin has biological properties, such as antioxidant [8], anti-inflammatory [9], anti-tumor [10], anti-diabetic [11], and anti-angiogenic [12] properties. Interestingly, Raffai et al reported that vanillin and vanillin analogues induced relaxation in porcine coronary and basilar arteries [13].…”

Section: Effect Of Vanillin On the Contraction Induced By High K + Or...mentioning

confidence: 99%

Vanillin Induces Relaxation in Rat Mesenteric Resistance Arteries by Inhibiting Extracellular Ca2+ Influx

Choi

Haam

et al. 2022

Molecules

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Vanillin is a phenolic aldehyde, which is found in plant species of the Vanilla genus. Although recent studies have suggested that vanillin has various beneficial properties, the effect of vanillin on blood vessels has not been studied well. In the present study, we investigated whether vanillin has vascular effects in rat mesenteric resistance arteries. To examine the vascular effect of vanillin, we measured the isometric tension of arteries using a multi-wire myograph system. After the arteries were pre-contracted with high K+ (70 mM) or phenylephrine (5 µM), vanillin was administered. Vanillin induced concentration-dependent vasodilation. Endothelial denudation or treatment of eNOS inhibitor (L-NNA, 300 μM) did not affect the vasodilation induced by vanillin. Treatment of K+ channel inhibitor (TEA, 10 mM) or sGC inhibitor (ODQ, 10 μM) or COX-2 inhibitor (indomethacin, 10 μM) did not affect the vanillin-induced vasodilation either. The treatment of vanillin decreased the contractile responses induced by Ca2+ addition. Furthermore, vanillin significantly reduced vascular contraction induced by BAY K 8644 (30 nM). Vanillin induced concentration-dependent vascular relaxation in rat mesenteric resistance arteries, which was endothelium-independent. Inhibition of extracellular Ca2+ influx was involved in vanillin-induced vasodilation. Treatment of vanillin reduced phopsho-MLC20 in vascular smooth muscle cells. These results suggest the possibility of vanillin as a potent vasodilatory molecule.

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Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose–streptozotocin induced diabetic rats

Cited by 11 publications

References 65 publications

Nutrient digestibility, ruminal fermentation, and blood metabolites of growing cattle-fed fermented cassava pulp with added flavoring agents

Nutrient digestibility, ruminal fermentation, and blood metabolites of growing cattle-fed fermented cassava pulp with added flavoring agents

Potential anti-HIV and antitrypanosomal components revealed in Sorindeia nitidula via LC-ESI-QTOF-MS/MS and molecular docking

Vanillin Induces Relaxation in Rat Mesenteric Resistance Arteries by Inhibiting Extracellular Ca2+ Influx

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