Vanishing Bile Duct Syndrome and Inflammatory Pseudotumor Associated with a Case of Anabolic Steroid Abuse

Capra, Franco; Nicolini, Nicoletta; Morana, Giovanni; Guglielmi, Alfredo; Capelli, Paola; Vantini, Italo

doi:10.1007/s10620-005-2876-2

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…It has been linked to a variety of etiologies, including autoimmune disorders, infectious diseases, primary neoplasms, genetic abnormalities, and a plethora of medications. 3,12 Approximately 1% of drug-induced cholestasis is thought to progress to VBDS. 13,14 Although postulated mechanisms of injury include immune-mediated damage, the pathogenesis of VBDS is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…1 Multiple case series and case reports have been published describing the presence of cholestatic liver injury following ingestion of AAS. [10][11][12][15][16][17][18][19][20][21] A recent case series describes 25 patients with AAS-induced liver injury, ten of which were cholestatic in nature -although liver biopsies were performed, the results were not reported 10 . Of the remaining case series and reports with cholestatic liver injury associated with AAS, only one patient had biopsy-confirmed VBDS on pathology.…”

Section: Discussionmentioning

confidence: 99%

“…Of the remaining case series and reports with cholestatic liver injury associated with AAS, only one patient had biopsy-confirmed VBDS on pathology. 12 The cornerstone of the management of acute liver injury in AAS is complete cessation of the offending agent, supportive management and meticulous monitoring of clinical and biochemical status. Of course, other more common causes of cholestasis should be ruled out through use of routine laboratory investigations A C a s e R e p o r t a n d L i t e r a t u r e R e v i e w and imaging techniques.…”

Section: Discussionmentioning

confidence: 99%

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Hepatic Ductopenia and Vanishing Bile Duct Syndrome Following Anabolic Androgenic Steroid Use: A Case Report and Literature Review.

Mazzetti

Alkhiari

Nair

et al. 2018

Can Journ Gen Int Med

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Vanishing bile duct syndrome (VBDS) is a rare acquired disorder associated with progressive destruction and disappearance of intrahepatic bile ducts which eventually leads to cholestasis. VBDS has been linked to a variety of etiologies, including autoimmune disorders, infectious diseases, primary neoplasms, genetic abnormalities, and many classes of medications, including antibiotics, nonsteroidal anti-inflamatories (NSAIDs), anticonvulsants, antipsychotics and others. We present the case of VBDS associated with anabolic androgenic steroid (AAS) exposure in an otherwise healthy 29-year-old male. Resume Le syndrome de disparition des canaux biliaires (SDCB) est une affection acquise rare caractérisée par la destruction progressive et la disparition des canaux biliaires intrahépatiques entrainant une cholestase. Le SDCB a été associé à diverses étiologies, dont des affections auto-immunes, des maladies infectieuses, des néoplasmes primaires, des anomalies génétiques et de nombreuses classes de médicaments, incluant des antibiotiques, des anti-inflammatoires non stéroïdiens, des anticonvulsivants, des antipsychotiques et autres. Nous présentons un cas de SDCB associé à la prise d’un stéroïde androgénique anabolisant chez un homme de 29 ans par ailleurs en bonne santé.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatic Ductopenia and Vanishing Bile Duct Syndrome Following Anabolic Androgenic Steroid Use: A Case Report and Literature Review.

Mazzetti

Alkhiari

Nair

et al. 2018

Can Journ Gen Int Med

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“…Another potential explanation for this process could involve the systemic effects of the steroid compounds. At least 1 case of a pseudotumor in the viscera has been associated with anabolic steroid abuse [12]. In addition, cases of benign soft tissue neoplasms with secondary growth [13] and occasional sarcomas [14,15] have been associated with anabolic steroids.…”

Section: Discussionmentioning

confidence: 99%

Factitial soft tissue pseudotumor due to injection of anabolic steroids: a report of 3 cases in 2 patients

2010

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Drug-induced cholestasis

et al. 2011

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Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug induced cholestasis. This review summarizes their variable clinical presentations, examines the, role of transport proteins in hepatic drug clearance and toxicity and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.

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Vanishing Bile Duct Syndrome and Inflammatory Pseudotumor Associated with a Case of Anabolic Steroid Abuse

Cited by 7 publications

References 18 publications

Hepatic Ductopenia and Vanishing Bile Duct Syndrome Following Anabolic Androgenic Steroid Use: A Case Report and Literature Review.

Hepatic Ductopenia and Vanishing Bile Duct Syndrome Following Anabolic Androgenic Steroid Use: A Case Report and Literature Review.

Factitial soft tissue pseudotumor due to injection of anabolic steroids: a report of 3 cases in 2 patients

Drug-induced cholestasis

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