Vanishing thyroid gland tumors: Infarction as consequence of FNA?

Kholová, Ivana

doi:10.1002/dc.23479

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…It is noteworthy that, in contrast to our data, all the cases of vascular changes were associated with necrosis. Our own necrosis cases were not accompanied by neovascularisation [21] .…”

Section: Discussionmentioning

confidence: 98%

“…Several subsequent studies confirmed their observations [16][17][18][19] . Thyroid FNAB-related histopathological changes often include haemorrhage, fibrosis, granulation tissue, and necrosis [15][16][17][18][19][20][21] . Necrosis and infarction of the thyroid gland had already been described before the WHAFFT concept, mainly as case reports and case series [22,23] .…”

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confidence: 99%

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Vascular Proliferation of the Thyroid: Potential Histopathological Pitfalls as a Consequence of Fine Needle Aspiration

Hovi

Kholová²

2017

Acta Cytologica

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Objective: Fine needle aspiration biopsy (FNAB) can cause reactive histopathological changes, commonly including haemorrhage and granulation tissue. The literature describing vascular proliferation after FNAB is sparse. We aimed to describe neovascularisation in thyroid gland specimens as a consequence of FNAB. Study Design: We analysed all thyroid histopathological specimens from the Fimlab Laboratories collected between 2010 and 2013 for neovascularisation and distortions in the accompanying tissue. We evaluated HE-stained slides and CD31-, podoplanin-, and Ki-67-immunostained slides. Results: We observed vascular proliferation in 64 out of 787 specimens (8.1%). In these patients, the mean age was 62 years, 43 were female and 21 were male. Previous FNAB data were available in 49 cases (76.6%). In 51 cases (79.7%), the neovascularisation occupied less than 5% of the thyroid gland area. The vessel dilatation was moderate in 28 cases (43.8%) and low in 20 cases (31.3%). In tumours, neovessels were detected within the tumour and in the surrounding tissue. Conclusions: Post-FNAB tissue samples include dilated newly formed vessels, which pathologists should differentiate from rare thyroid vascular tumours. The proposed mechanism is a traumatically induced haemorrhage followed by haematoma and thrombosis that resolves by recanalisation. A knowledge of tissue alteration is needed to avoid misdiagnoses.

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“…It is noteworthy that, in contrast to our data, all the cases of vascular changes were associated with necrosis. Our own necrosis cases were not accompanied by neovascularisation [21] .…”

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Vascular Proliferation of the Thyroid: Potential Histopathological Pitfalls as a Consequence of Fine Needle Aspiration

Hovi

Kholová²

2017

Acta Cytologica

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“…The size of the FNA needle and the number of needle punctures used may influence the post-FNA changes or US interval changes in STNs. Previous studies have reported that needle injury is known to be closely associated with post-FNA changes ( 19 ). In terms of the pathogenic mechanism, needle injury causes direct interruption of the microvascular supply and venous thrombosis ( 7 8 9 ).…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Interval Changes in Solid Thyroid Nodules after Ultrasonography-Guided Fine-Needle Aspiration

et al. 2018

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ObjectiveNone of the previous studies have investigated the interval change in ultrasonography (US) features of solid thyroid nodules (STNs) after US-guided fine-needle aspiration (US-FNA). This study aimed to assess the prevalence and characteristics of US interval changes in STNs after US-FNA.Materials and MethodsThis study included 257 STNs in 257 patients in whom thyroid US and initial US-FNA had been performed by two radiologists from January 2015 to June 2015. One of the radiologists performed single needle puncture in all cases, whereas the other radiologist used double or triple needle punctures. Follow-up US examinations were performed after 12.0 ± 6.0 months. We evaluated the prevalence and characteristics of post-FNA US interval changes through a retrospective analysis. In addition, multiple factors were correlated with post-FNA US interval changes.ResultsThe number of needle punctures was one (n = 91), two (n = 163), and three (n = 3). Of the 257 STNs (mean diameter, 11.9 mm) in 257 patients, 35 (13.6%) showed an interval change in US features on follow-up US. Among them, 17 STNs (6.6%) showed newly developed malignant US features, including hypoechogenicity (n = 5), microcalcifications (n = 2), a spiculated margin (n = 4), hypoechogenicity with a spiculated margin (n = 5), and microcalcifications with non-parallel orientation (n = 1). Between patients who showed presence and absence of US interval changes, there were no significant differences in patient age, sex, nodule size, dichotomization, and location, Korean Thyroid Imaging Reporting and Data System categorization after FNA, practitioners involved, number of needle punctures, cytological findings, and interval between FNA and US follow-up (p > 0.05).ConclusionAwareness of US interval changes after US-FNA of STNs may be helpful for the management of STNs.

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“…The novelty of ACR-TIRADS is the method of scoring both echogenic foci and calcifications, which are additive features given more weight than in other systems. Some authors have suggested modifying TIRADS [13,[20][21][22][23][24]. Park et al established a new system with 12 characteristics even though its application proved to be difficult, [13] and Kwak et al proposed a more practical classification system including only five US features [14].…”

Section: Overview Of Acr-tiradsmentioning

confidence: 99%

Overview of the Ultrasound Classification Systems in the Field of Thyroid Cytology

Rossi

Pantanowitz

Raffaelli

et al. 2021

Cancers

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The increasing application of ultrasound (US) in recent years has led to a greater number of thyroid nodule diagnoses. Consequently, the number of fine needle aspirations performed to evaluate these lesions has increased. Although the majority of thyroid nodules are benign, identifying methods to define specific lesions and tailor risk of malignancy has become vital. Some of the tools employed to stratify thyroid nodule risk include clinical factors, thyroid US findings, and reporting systems for thyroid cytopathology. Establishing high concordance between US features and cytologic diagnoses might help reduce healthcare costs by diminishing unnecessary thyroid procedures and treatment. This review aims to review radiology US classification systems that influence the practice of thyroid cytology.

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Vanishing thyroid gland tumors: Infarction as consequence of FNA?

Cited by 10 publications

References 31 publications

Vascular Proliferation of the Thyroid: Potential Histopathological Pitfalls as a Consequence of Fine Needle Aspiration

Vascular Proliferation of the Thyroid: Potential Histopathological Pitfalls as a Consequence of Fine Needle Aspiration

Ultrasonographic Interval Changes in Solid Thyroid Nodules after Ultrasonography-Guided Fine-Needle Aspiration

Overview of the Ultrasound Classification Systems in the Field of Thyroid Cytology

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